RNA Interference (RNAi)

RNA interference (RNAi) employs small interfering RNAs to selectively degrade messenger RNA, reducing expression of disease-driving genes. RNAi enables precision modulation of pathogens, immune signaling, and wound biology and can be formulated for local or systemic delivery in austere and combat environments.

Technical Challenges

  • Safe, efficient delivery of RNAi agents to target cells in wounded tissue, lung, or CNS under constrained resources.

  • Stability and storage: ensuring cold-chain–independent formulations suitable for prolonged field care and forward deployment.

  • Off-target effects, immunogenicity, and dose-dependent toxicity in polytrauma or sepsis patients.

  • Rapid design and deployment against evolving pathogens and antimicrobial-resistant organisms.

Emerging Opportunities

  • Robust, room-temperature-stable delivery platforms that preserve potency for field-ready kits.

  • Validated animal-to-human translational models for trauma, biofilm infections, and blast-induced neuroinflammation.

  • Point-of-care diagnostics to identify actionable gene targets and guide RNAi selection in real time.

  • Manufacturing surge capacity and regulatory pathways for emergency military use and rapid clinical translation.

Current and Emerging Technologies in RNA Interference (RNAi)

siRNA Therapeutics & Target Design

Rationally designed siRNAs and RNAi libraries targeting virulence factors, inflammatory mediators (e.g., TNF, IL-6), or bacterial persistence genes enable precision modulation of disease pathways.

Delivery Platforms: Lipid Nanoparticles, Conjugates, and Hydrogels

LNPs, GalNAc and peptide conjugates, inhalable aerosols, and local depot hydrogels address tissue targeting, uptake, and sustained release for pulmonary, wound, or systemic applications.

Chemical Modifications & Formulation Stability

2’-O-methylation, phosphorothioate backbones, and novel excipient matrices improve nuclease resistance, reduce immunogenicity, and enable lyophilized or ambient-stable formulations.

Targeted Delivery & Controlled Release Systems

Antibody- or ligand-directed carriers, implantable depots, and responsive nanoparticles allow site-specific gene silencing to minimize systemic exposure in polytrauma or infection.

Integrated Diagnostics and Rapid Design Pipelines

Point-of-care nucleic acid diagnostics, bioinformatic target selection, and rapid synthesis platforms support agile RNAi countermeasure development for outbreaks or theater-specific threats.

Importance to Military Medicine

Combat Casualty Care and Inflammation Control

RNAi can selectively suppress hyperinflammatory signaling after blast or hemorrhagic shock, reducing secondary tissue injury and improving stabilization during delayed evacuation.

Prolonged Field Care and Localized Therapy

Stable, deployable RNAi formulations for wound infection, lung injury, or hemorrhage can extend therapeutic windows when surgical or critical care resources are limited.

Countering Infectious Threats and AMR

Gene silencing of virulence or resistance determinants offers an adjunct to antibiotics and a rapid-response option against engineered or emerging pathogens.

Readiness and Force Health Protection

Prophylactic or early-intervention RNAi strategies can preserve troop readiness during outbreaks and reduce evacuation burdens during large-scale incidents.

Alignment with the MTEC Mission

Enables rapid translational pipelines from concept to theater-ready countermeasures—aligned with MTEC’s mission to accelerate military medical innovations.

Supports force health protection priorities (infectious disease, trauma, prolonged care) across distributed and austere operational environments.

Promotes public–private partnerships for manufacturing scale-up, regulatory pathways, and dual-use benefits consistent with the MTEC consortium model.

Dual-Use (Military + Civilian) Applications

Therapeutics: adjuncts or alternatives to antibiotics for resistant infections and biofilms in both military and civilian trauma care.

Prophylaxis and outbreak response: rapid-design RNAi countermeasures for novel or engineered pathogens affecting deployed forces and communities.

Regenerative and wound care: localized gene silencing to control scarring, fibrosis, or chronic infection in austere surgical settings.

Diagnostics-driven precision medicine: integrated platforms that link point-of-care testing to tailored RNAi interventions for timely, mission-focused treatment.

Explore MTEC Members with RNA Interference (RNAi) Capabilities

MTEC members bring multidisciplinary strengths—RNA biology, nanoparticle engineering, clinical trial networks, and GMP manufacturing—to accelerate RNAi solutions from bench to battlefield.

Together, consortium partners can de-risk preclinical validation, advance regulatory strategies for military use, and scale ambient-stable formulations for forward deployment. Explore member profiles to identify collaborators with capabilities in target discovery, delivery platforms, and clinical translation.

94 Members with RNA Interference (RNAi) capabilities.

Member
The University of Texas System

The University of Texas System is a leading public university system in the United States, dedicated to improving lives through education, health care, and research. With over 256,000 students enrolled across 14 institutions, the UT System is committed to providing affordable access to higher education and producing a skilled workforce to drive Texas's economy.

Member
Georgia Southern University

Georgia Southern University is a vibrant institution with over 26,100 students across three campuses in Statesboro, Savannah, and Hinesville. The university offers 132 degree programs at the associate, bachelor’s, master’s, and doctorate levels, emphasizing student success, community impact, and research excellence. With a commitment to inclusivity and engagement, Georgia Southern fosters a supportive environment for diverse learners, including military-affiliated and adult students. The university is dedicated to transforming lives through education and community engagement, aligning its programs with regional needs. Additionally, Georgia Southern provides accelerated pathways for students to fast-track their master's degrees, enhancing educational opportunities. The university also emphasizes career readiness and public impact research, preparing students for successful careers and contributing to community development.

Member
Humanetics Corporation

Humanetics Corporation is a clinical-stage pharmaceutical company based in Minneapolis, Minnesota, focused on developing and commercializing products to enhance human health and wellbeing. Founded in 1988, the company specializes in radiation modulators, adjunctive oncology therapies, and pulmonary protective therapies, particularly for COVID-19. Humanetics is known for its lead drug candidate, BIO 300, which is being developed as a radioprotectant for military and civilian use, as well as a treatment to improve outcomes in cancer patients receiving radiotherapy. The company is actively engaged in research programs for non-small cell lung cancer, prostate cancer, and head and neck cancers.

Member
The University of Texas at San Antonio

The University of Texas at San Antonio (UTSA) is dedicated to the advancement of knowledge through research, teaching, and community engagement. As a premier public research university, UTSA embraces multicultural traditions and serves as a catalyst for socioeconomic development, providing access to educational excellence and preparing citizen leaders for the global environment.

Member
Auburn University

Auburn University Research & Economic Development is dedicated to advancing research and economic growth through a collaborative effort among its various colleges and departments. The organization focuses on fostering innovation, supporting faculty and student research, and facilitating partnerships with industry and government to address societal challenges and enhance the quality of life. Recent initiatives include the launch of the Team Science Series to promote interdisciplinary collaboration and the development of the Gulf Coast Engineering Research Station to address coastal environmental challenges.

Member
Institute for Integrative & Innovative Research (I³R) at University of Arkansas

The Institute for Integrative & Innovative Research (I³R) at the University of Arkansas is dedicated to pioneering solutions to wicked problems and societal challenges through convergence research. With a mission to advance research excellence and stimulate economic development, I³R focuses on deploying innovations at scale through collaboration across various sectors, including academia, industry, and government.

Member
The University of Texas Medical Branch at Galveston

UTMB is dedicated to supporting research, education, and scholarly endeavors, with a focus on creating the future of healthcare through innovative research and community engagement.

Member
Revolution Biomanufacturing Inc.

Revolution Biomanufacturing Inc. (RBIx) is expanding beyond traditional CDMO Process/Analytical Development and Manufacturing services to pioneer distributed molecular manufacturing. A new class of digital biomanufacturing that enables the autonomous design, manufacture, quality verification, and deployment of Nucleic Acid therapeutics and molecular diagnostics at the point of need. By integrating AI-driven sequence optimization, enzymatic nucleic acid synthesis, Nanoparticle design and manufacturing (LNP & EV), closed-loop quality control, and field-deployable manufacturing platforms, RBIx is creating adaptive biological infrastructure capable of responding to emerging diseases, national security threats, and personalized medicine with unprecedented speed and flexibility.

Member
The University of Chicago

The University of Chicago is a prestigious urban research university committed to rigorous inquiry and intellectual freedom. Founded in 1890, it has produced numerous Nobel laureates and is known for its transformative education and groundbreaking research across various fields. The university fosters an inclusive and diverse learning environment, encouraging participation from all community members.

Member
Boston University

Boston University is a major research institution committed to leading breakthroughs across various disciplines. The Office of Research supports and advances research excellence, fostering collaboration among researchers, industry partners, and government leaders to address significant societal challenges.

Member
Cooper University Health Care

Cooper University Health Care is a regional academic health system recognized for comprehensive clinical services, advanced multidisciplinary care, specialized surgery, and robust research in South Jersey. It provides integrated healthcare across general and specialty domains, including cancer, neurosciences, cardiology, trauma, genetics, addiction medicine, and complex surgical procedures, supported by leading technologies and a network of modern facilities.

Member
Baylor University

Baylor University is a preeminent Christian research university committed to addressing the world's most meaningful challenges through top-tier research and scholarship. Recognized as an R1 research institution, Baylor focuses on infusing its distinct Christian mission into its research initiatives, fostering a commitment to excellence and innovation.

Member
Base Pair Biotechnologies

Base Pair Biotechnologies specializes in custom aptamer discovery and development for research, diagnostics, therapeutics, and industrial applications. The company leverages proprietary multiplex selection, advanced bioinformatics, and chemical modification techniques to develop high-affinity and selective nucleic acid aptamers. Base Pair enables affinity reagent development, biosensor design, and molecular detection for a broad range of targets and partners across academia and industry.

Member
Nanovaccine Institute

The Nanovaccine Institute, established at Iowa State University in 2017, is a national transdisciplinary research consortium focused on advancing nano-based technologies to treat and prevent diseases. The institute aims to revolutionize public health outcomes through the design and promotion of nano-based vaccines and therapeutics.

Member
The University of Texas at Arlington Research Institute

The UT Arlington Research Institute (UTARI) specializes in applying cutting-edge technologies to real-world engineering problems. Our collaborative endeavors reflect a commitment to excellence, integrity, and respect for all, bringing economic growth and fulfillment to our families, business partners, university, and community.

Member
Smith+Nephew

Smith+Nephew is a portfolio medical technology company focused on the repair, regeneration, and replacement of soft and hard tissue. The company aims to restore people's bodies and their self-belief by using technology to take the limits off living. With a commitment to medical education and improving patient outcomes, Smith+Nephew operates in over 100 countries and is dedicated to sustainability and community health. Their purpose is to promote health and wellbeing, not just through their products but also by ensuring a positive impact on society and the environment. Smith+Nephew is also committed to increasing diversity within the medical device industry through initiatives like the Orthopaedics for All global advisory board.

Member
Florida Research & Innovation Center

Florida Research & Innovation Center (FRIC) is a biomedical research organization specializing in infectious and inflammatory diseases, immunology, vaccine development, cancer biology, and organ transplantation immunology. The center emphasizes both basic and translational research, investigating mechanisms of disease, host-pathogen and host-tumor interactions, and sex-specific immune mechanisms. FRIC supports research with advanced core facilities in flow cytometry, imaging, and bioinformatics, and provides hands-on education and workforce development in biomedical research.

Member
University of Maryland, Baltimore

The University of Maryland, Baltimore (UMB) is Maryland’s public health, law, and human services university. It is dedicated to improving the human condition and serving the public good through education, research, clinical care, and service. UMB is the founding campus of the University System of Maryland and offers a wide range of professional degrees in health care, human services, and law.

Member
University of North Carolina Wilmington

The University of North Carolina Wilmington (UNCW) is a top doctoral and research institution located in Wilmington, North Carolina. Established in 1947, UNCW has grown to serve nearly 18,000 students and employs about 2,500 staff. The university is dedicated to providing a powerful academic experience that fosters creative inquiry, critical thinking, and thoughtful expression in a beautiful coastal setting. UNCW is committed to educational excellence, community engagement, and global connections, making it a vibrant part of the southeastern North Carolina community. UNCW also emphasizes the importance of freedom of expression and mutual respect within its diverse community.

Member
University of Missouri-Kansas City

The University of Missouri-Kansas City (UMKC) is dedicated to transforming today's learners into tomorrow's leaders through innovative education, research, and community engagement. With over 125 academic programs, UMKC fosters a diverse and inclusive environment that empowers students to achieve their goals and make a positive impact in their communities.

Member
Mayo Clinic

Mayo Clinic is the largest integrated, not-for-profit medical group practice in the world, dedicated to providing high-quality, patient-centered care. With a history of innovation spanning nearly 150 years, Mayo Clinic is committed to transforming healthcare through research, education, and compassionate care, ensuring that the best possible treatment is available to everyone.

Member
Ambient Biosciences

Ambient Biosciences is a global leader in biostabilization, dedicated to eliminating cold chain reliance and improving global health equity through innovative biomolecule stabilization technology. Their patented Capillary-Assisted Vitrification (CAV) process enables room-temperature storage and shipping of sensitive reagents and biomolecules, offering a superior alternative to traditional lyophilization and cryopreservation. With a values-driven, diverse team of scientific experts and visionary leaders, Ambient Biosciences is committed to transforming laboratory operations, reducing costs and waste, and making life sciences more accessible and sustainable worldwide.

Member
Temple University

Temple University is Philadelphia’s only public university and a global center of academic excellence. It is classified as an R1 institution, indicating very high research activity, and offers over 600 academic programs across 17 diverse schools and colleges. The university is committed to providing accessible education that fosters positive change and prepares students to become leaders in their fields. Additionally, Temple emphasizes a vibrant campus life enriched by arts, culture, and a commitment to diversity and inclusivity. The university also promotes a tobacco-free environment to enhance the health and well-being of its community. Temple's athletics program further enhances student life, with 19 varsity teams competing at the NCAA Division I level, fostering school spirit and community engagement.

Member
University of Kentucky

The Office of Sponsored Projects Administration (OSPA) at the University of Kentucky is dedicated to transforming tomorrow by streamlining grants and contracts. OSPA provides essential services to faculty and staff, including assistance with proposal preparation, award negotiation, and compliance with sponsor policies.

Member
Southwest Research Institute (SwRI)

Southwest Research Institute (SwRI) is a nonprofit research and development organization that provides independent, premier services to government and industry clients. Founded in 1947, SwRI is committed to advancing science and technology to benefit humanity, focusing on innovative solutions that improve human health and safety. With a diverse range of technical divisions, SwRI addresses complex challenges in various fields including mechanical engineering, materials, aerospace, automotive, biomedical, and more.

Member
The University of Texas at Dallas

The University of Texas at Dallas (UT Dallas) is a top public research university located in Richardson, Texas, known for its innovative programs, renowned faculty, and a commitment to academic excellence. With over 31,000 students across seven schools, UT Dallas offers a diverse range of undergraduate and graduate programs designed to prepare students for leadership roles in various fields including science, engineering, business, and the arts. The university emphasizes research, community engagement, and student success, making it a vibrant hub for learning and innovation. Additionally, UT Dallas is recognized for its strong return on investment, high graduation rates, and successful career placement for graduates, with many students continuing their education at prestigious graduate schools.

Member
SRI International

SRI International is an independent nonprofit research institute with a rich history of supporting government and industry. For almost 80 years, SRI has collaborated across technical and scientific disciplines to discover and develop groundbreaking products and technologies, delivering world-changing solutions for a safer, healthier, and more sustainable future. The Nomura-SRI Innovation Center (NSIC) further enhances SRI's mission by bridging the gap between Japan and Silicon Valley, fostering corporate innovation and talent development.

Member
Macro Biologics, Inc.

Macro Biologics, Inc. is dedicated to designing, patenting, and producing macro biologics, which are large molecule biologics with both physical properties and functional activities. These biologics are composed of natural building blocks, such as amino acids or carbohydrates, and are designed to degrade back into their natural components, making them environmentally friendly. The company aims to address significant global challenges, such as antibiotic resistance and pollution, by providing biologics that are safe for both people and the environment. Macro Biologics is committed to the highest standards of science, medicine, and business, with a focus on healthcare applications.

Member
Nanomedicine Manufacturing Lab, Duquesne University

Nanomedicine Manufacturing Laboratory (NML) is a research and development laboratory specializing in nanomaterials and biomaterials for imaging, oxygen delivery, and drug delivery, with a core emphasis on scalable manufacturing and Quality-by-Design (QbD). More information about NML: https://www.duq.edu/research/faculty-research/nanomedicine-lab/nanomed-lab-research.php Led by Dr. Jelena M. Janjic, the Nanomedicine Manufacturing Laboratory develops colloidal nanosystems and implantable biomaterials that support molecular imaging modalities, including magnetic resonance imaging (MRI) and near-infrared fluorescence; biosensing, drug delivery; oxygen delivery; and theranostic nanomaterials, used for local and parenteral administration or as implantable biomaterials. A major barrier to the advancement of nanotechnology-based therapeutics is not conceptual innovation but manufacturability, cost, and quality control. The Nanomedicine Manufacturing Laboratory addresses these challenges by incorporating manufacturing process design, scalability, and quality control at the earliest stages of material design. Over the past decade, the laboratory has established robust, reproducible, and cost-effective nanomedicine manufacturing methods by applying QbD frameworks, enabling reliable scale-up and controlled performance. The laboratory’s work is supported by the U.S. Air Force, the Congressionally Directed Medical Research Programs (CDMRP), and ARPA-H through collaborative programs spanning academia, industry, and government. The Nanomedicine Manufacturing Laboratory operates at the intersection of materials science, manufacturing, and translational medicine, with a focus on developing innovative nanomedicines and biomaterials that translate into accessible, cost-effective future treatments for civilian and military medical needs.

Member
University of Arizona Applied Research Corporation (UA-ARC)

The University of Arizona Applied Research Corporation (UA-ARC) is a non-profit organization affiliated with the University of Arizona, dedicated to leveraging the university's strengths in research and education to address national security challenges. UA-ARC aims to deliver innovative solutions and foster collaborations between academia, industry, and government.

Member
University of Utah

The University of Utah (UU) is a leading research institution recognized for its research activity and commitment to innovation and discovery. As an R1 Institution, it is dedicated to advancing knowledge and solving critical problems that challenge our national security interests and impact the global community. We foster interdisciplinary collaboration and provide resources to drive transformative research focused on enhancing medical care superiority for the U.S. Department of Defense (DoD) through advanced medical and engineering research sponsored by our Applied Medical & Engineering Laboratory (AM&E Lab). As a leading public university, UU also provides healthcare services to seven states in the Intermountain West, with the largest catchment of remote and austere frontier territory for any academic center. Leveraging its geographic advantage, technological and commercialization strengths, expertise in medical services, and leading-edge, core engineering competencies, UU is uniquely positioned to address the nation's critical national security interests.

Member
LenioBio GmbH

LenioBio GmbH develops scalable eukaryotic cell-free protein expression technologies enabling rapid and flexible production of complex proteins. Its proprietary platform facilitates expression of membrane proteins, antibodies, virus-like particles, and proteins with complex post-translational modifications, supporting applications from research to biomanufacturing and vaccine development. The technology addresses key bottlenecks in traditional protein production, offering fast turnaround, batch consistency, and the potential for integration with rapid DNA template synthesis. LenioBio collaborates with leading industry partners and continually advances its platform for broad accessibility and application in life sciences.

Member
George Mason University

The Institute for Biohealth Innovation (IBI) at George Mason University unites over 300 faculty and thousands of students across 34 departments to advance human health and well-being through innovative research. The IBI focuses on major health challenges, including infectious diseases, cancer, brain and behavior, and cardiovascular health, collaborating with national and international partners to implement solutions that enhance health outcomes.

Member
University of Minnesota

The University of Minnesota's Research and Innovation Office (RIO) serves as a central resource for conducting, managing, and sponsoring research. It aims to facilitate collaborative research that addresses complex problems and promotes innovations that improve lives. RIO oversees research compliance and administration, fostering a culture of integrity and ethical practices in research. Additionally, RIO is committed to enhancing research capacity through various funding opportunities and strategic initiatives, including the management of specialized facilities for biocontainment research.

Member
University of Notre Dame

The University of Notre Dame, founded in 1842, is a prestigious Catholic research university located in South Bend, Indiana. It is dedicated to providing a holistic education that integrates faith, reason, and service to others. The university aims to be a leading global Catholic research institution, fostering a community of scholars committed to inquiry, justice, and the common good.

Member
New York University

New York University (NYU) is a global university that connects talented and ambitious individuals in some of the world's greatest cities. Its mission is to be a top-quality institution, providing a diverse range of academic programs and opportunities for students to engage with the world's challenges. NYU is committed to fostering innovation and entrepreneurship, and it emphasizes diversity, equity, and inclusion in its educational mission. Founded in 1831, NYU has evolved to become a leader in higher education, with a commitment to accessibility and a diverse student body. NYU offers a wide array of academic programs, including accelerated studies and online education, catering to the needs of a global student population.

Member
Wyss Institute for Biologically Inspired Engineering at Harvard University

The Wyss Institute for Biologically Inspired Engineering uses biological design principles to develop new engineering innovations that will transform medicine and create a more sustainable world. At the Wyss Institute, we leverage recent insights into how Nature builds, controls and manufactures to develop new engineering innovations - a new field of research we call Biologically Inspired Engineering. By emulating biological principles of self assembly, organization and regulation, we are developing disruptive technology solutions for healthcare, energy, architecture, robotics, and manufacturing, which are translated into commercial products and therapies through formation of new startups and corporate alliances.

Member
Northwestern University

Northwestern University is a prestigious institution dedicated to fostering a diverse and inclusive environment, promoting academic excellence, and engaging in impactful research. With campuses in Evanston, Chicago, and Doha, Qatar, Northwestern emphasizes global engagement and community involvement, preparing students to tackle complex challenges through interdisciplinary collaboration and innovative thinking.

Member
The University of Iowa

The University of Iowa is dedicated to providing a comprehensive educational experience that fosters academic excellence, research opportunities, and a vibrant student life. With a commitment to accessibility and inclusivity, the university aims to prepare its students for success in various fields while promoting a supportive community.

Member
Case Western Reserve University

Case Western Reserve University is dedicated to solving the biggest issues of today and tomorrow through innovative research and education. With a commitment to experiential learning, the university offers a wide range of programs and opportunities for students to engage in research, internships, and community service, all within a vibrant campus located in Cleveland, Ohio.

Member
University of Alaska Fairbanks

The University of Alaska Fairbanks (UAF) is a Land, Sea, and Space Grant university and an international center for research, education, and the arts, emphasizing the circumpolar North and its diverse peoples. UAF integrates teaching, research, and public service as it educates students for active citizenship and prepares them for lifelong learning and careers.

Member
University of South Florida

The University of South Florida (USF) is a Preeminent Research University and member of the Association of American Universities (AAU), dedicated to empowering students to maximize their potential for lifelong success. With campuses across the vibrant Tampa Bay region, USF serves nearly 50,000 students and offers a wide range of academic programs, innovative research opportunities, and a commitment to community engagement.

Member
New Jersey Institute of Technology

New Jersey Institute of Technology (NJIT) is a leading public research university dedicated to providing students with a world-class education in STEM fields and beyond. With a commitment to academic excellence, NJIT prepares students to be leaders in the most in-demand fields through innovative programs, expert faculty, and extensive research opportunities. NJIT is recognized for its affordability and return on investment, making it a top choice for students seeking a quality education. NJIT is also ranked among the top public universities in the nation, known for its diverse student body and commitment to fostering an inclusive environment.

Member
University of Arkansas for Medical Sciences Office of Research and Sponsored Programs

The University of Arkansas for Medical Sciences Office of Research and Sponsored Programs (ORSP) is dedicated to supporting UAMS faculty in acquiring, performing, and administering projects funded by external sources. The ORSP ensures compliance with policies, negotiates award terms, liaises between investigators and sponsors, and manages subcontracts.

Member
The University of Virginia

Founded by Thomas Jefferson in 1819, the University of Virginia is a prestigious public university that emphasizes the advancement of human knowledge, education of leaders, and cultivation of an informed citizenry. It is recognized for its commitment to academic excellence, vibrant student life, and a strong alumni network, making it one of the top public universities in the United States.

Member
University of Missouri

The University of Missouri is dedicated to advancing research, innovation, and impact through a comprehensive support system for faculty, students, and staff. It aims to foster collaboration, enhance economic development, and promote entrepreneurship, while ensuring compliance with research regulations and ethical standards. The university also emphasizes the importance of interdisciplinary partnerships and provides resources to support veteran entrepreneurs through programs like the Entrepreneurship Bootcamp for Veterans.

Member
Prolific Machines

Prolific Machines is pioneering the use of optogenetics and AI-driven bioprocess optimization to revolutionize biomanufacturing. Their mission is to illuminate biology’s limitless potential for a healthier tomorrow by enabling the production of next-generation therapeutics and broadening patient access to life-altering medicines. Founded in 2020, the company has developed a unique Photomolecular™ platform that uses light to precisely control cellular functions, boosting yields, improving quality, and enabling the manufacture of complex biotherapeutics. With a focus on strategic partnerships, Prolific Machines collaborates with innovators in biopharma and advanced nutrition, offering flexible, scalable solutions and in-house cell line development up to 200-liter pilot scale. The company is recognized for its commitment to safety, innovation, and a collaborative, diverse team culture.

Member
University of Massachusetts Lowell

The University of Massachusetts Lowell (UML) is dedicated to providing a comprehensive educational experience that prepares students for success in their careers and lives. With over 200 degree programs and a commitment to research and community engagement, UML fosters a vibrant learning environment for its diverse student body.

Member
Aphios

Aphios is a green biotechnology company focused on developing enabling nanotechnology platforms and enhanced therapeutics for health maintenance, disease prevention, and treatment of various conditions including cancers, infectious diseases, and central nervous system (CNS) disorders. The company emphasizes environmentally-sustainable practices and aims to improve the quality of life through innovative therapies.

Member
ICaPath, Inc.

ICaPath, Inc. is a biotechnology company developing immunotherapy solutions for cancer and serious diseases, with a focus on patent-protected, PLGA-based nanoparticle drug delivery systems. The company's platform enables controlled, sustained-release delivery of cytokines such as interleukin-12, improving immune stimulation while reducing toxicity. This approach is complemented by immune profiling diagnostics for precision medicine, and the company includes expertise spanning biologics manufacturing, translational research, and regulatory advancement for new therapies.

Member
University of Nebraska Medical Center

The University of Nebraska Medical Center (UNMC) is dedicated to transforming lives through premier educational programs, innovative research, and extraordinary patient care. Founded in 1869, UNMC is a leader in health sciences education and research, serving as a vital resource for Nebraska and beyond.

Member
University of Georgia

The University of Georgia (UGA) is dedicated to facilitating instruction, scholarly and creative activity, and research collaborations across disciplines. UGA is a leader in research-based products and innovation, significantly impacting the state of Georgia and beyond through its extensive research initiatives and academic programs.

Member
MassBiologics

MassBiologics, part of UMass Chan Medical School, is the only nonprofit, FDA-licensed manufacturer of vaccines and biologics in the United States. With over 100 years of experience, it is dedicated to improving public health through the research, development, and production of biologic products, including vaccines and monoclonal antibodies.

Member
Lovelace Biomedical

Lovelace Biomedical is a not-for-profit preclinical contract research organization specializing in advancing new therapies, assessing drug and toxicant risks, and characterizing disease using comprehensive in vivo and in vitro models. Leveraging a GLP-compliant facility and scientific collaborations, the organization provides expertise in toxicology, gene therapy, respiratory, infectious disease, neuroscience, and cell biology, with a commitment to quality, regulatory compliance, and advanced analytical capabilities.

Member
Ceres Nanosciences, Inc.

Ceres Nanosciences, Inc. is a privately held company based in Northern Virginia, specializing in the development and commercialization of Nanotrap® hydrogel particle technology. Their mission is to deliver innovative products powered by Nanotrap Technology to address life science needs and provide better patient outcomes. Ceres' products enable the capture, concentration, and preservation of low-abundance analytes from diverse biological and environmental samples, supporting applications in diagnostics, research, and public health surveillance. The company is ISO 9001:2015 certified and collaborates with leading research institutions, public health agencies, and industry partners to advance global health security and biosecurity. Ceres has established a national network of Wastewater-based Epidemiology Centers of Excellence and has received significant funding from the NIH RADx initiative and other organizations to expand its impact in underserved communities. Their technology is widely adopted for wastewater-based epidemiology, proteomics, and nucleic acid analysis, with a strong focus on supporting public health monitoring, early detection of infectious diseases, and environmental bio-surveillance.

Member
Medical University of South Carolina

The Medical University of South Carolina (MUSC) is South Carolina’s premier biomedical research institution, dedicated to advancing health through innovative research, education, and clinical care. With over $300 million in research funding and a commitment to addressing pressing health challenges, MUSC fosters collaboration among faculty, staff, and community partners to translate scientific discoveries into impactful health solutions. The South Carolina Clinical & Translational Research Institute (SCTR) at MUSC supports innovative research across the translational spectrum, from basic science to population health, including patient-centered and community-engaged research.

Member
Bioneer

Bioneer is a biotechnology company specializing in molecular biology, offering solutions in nucleic acid synthesis, molecular diagnostics, protein production, and laboratory automation. The company's expertise covers oligonucleotide chemistry, gene synthesis, sample preparation, molecular diagnostics, and analytical services such as mass spectrometry and sequencing, serving clinical, research, and industrial sectors globally.

Member
University of Florida

The University of Florida is a leading public university that fosters innovation, education, and research. With a commitment to excellence, the university provides a diverse and inclusive environment for students, faculty, and staff, driving impactful discoveries and community engagement.

Member
University of California, Irvine

The UCI Office of Research is dedicated to supporting and enhancing the creative and scholarly activities of UCI faculty and researchers. It provides central administrative support for research programs, ensuring compliance with regulations and fostering an environment conducive to research and innovation.

Member
Codagenix

Codagenix is a clinical-stage synthetic biology company specializing in the design and development of live-attenuated vaccines and viral therapeutics for infectious diseases, cancer, and animal health. Utilizing a proprietary platform that combines codon deoptimization and synthetic biology, Codagenix rapidly engineers viral genomes to create stable, broadly immunogenic, and scalable solutions. Its pipeline includes vaccines targeting dengue, RSV, influenza, COVID-19, yellow fever, Zika, and foot-and-mouth disease, as well as virotherapeutics for cancer and animal health. The company partners with academic institutions, global health organizations, and federal agencies to address critical global health challenges.

Member
Virginia Polytechnic Institute

Virginia Tech is a leading research institution dedicated to improving the quality of life and the human condition through education, research, and community engagement. With a commitment to its motto, 'Ut Prosim' (That I May Serve), Virginia Tech fosters a collaborative environment that integrates technology into all disciplines, preparing scholars to be leaders and problem-solvers.

Member
Louisiana State University Health Sciences Center New Orleans

LSU Health Sciences Center New Orleans is dedicated to educating future health professionals and scientists, advancing research, and providing exceptional healthcare. With six professional schools and numerous affiliated hospitals, LSUHSC-NO aims to improve health outcomes and address health equity challenges in Louisiana.

Member
The University of Texas Permian Basin

The University of Texas Permian Basin (UTPB) offers a modern, affordable education in the heart of West Texas, focusing on student success and community impact. With a commitment to providing a diverse range of undergraduate and graduate programs, UTPB aims to empower students to achieve their academic and career goals while contributing positively to the region. UTPB also emphasizes professional development through innovative programs like the Coursera Career Academy and the Impact Behavioral Health Scholarship, which covers tuition and fees for graduate students in specific programs.

Member
NaNotics

NaNotics is developing a new class of nanomedicine focused on the selective depletion of harmful soluble proteins implicated in cancer and other diseases. The company's injectable nanoparticle platform is designed to target and clear pathogenic soluble molecules from circulation without affecting essential membrane-bound forms, offering an innovative therapeutic approach for previously undruggable targets. The technology is modular, allowing rapid adaptation to new disease indications, and is supported by a strong patent portfolio and collaborative development with leading medical institutions.

Member
Zymo Research

Zymo Research is a global biotechnology company specializing in innovative products and services for sample collection, nucleic acid purification, microbiomics, epigenetics, and next-generation sequencing (NGS). With over 30 years of experience, Zymo Research is recognized for simplifying complex scientific workflows and providing reliable solutions for life science research, clinical diagnostics, and molecular biology applications. The company offers a comprehensive portfolio of kits, standards, and services designed to ensure accuracy, reproducibility, and efficiency in molecular analyses, supporting researchers worldwide.

Member
Northeastern University

Northeastern University is a global research university founded in 1898, renowned for its experiential learning model, high-impact research, and deep partnerships. The university emphasizes innovative teaching and research that engage students, faculty, and alumni in solving real-world problems, fostering a dynamic and inclusive community across its 13 campuses worldwide.

Member
Edward Via College of Osteopathic Medicine

The Edward Via College of Osteopathic Medicine (VCOM) is dedicated to preparing globally minded, community-focused osteopathic physicians to meet the needs of rural and medically underserved populations. VCOM emphasizes research to improve human health and offers a comprehensive medical education across its campuses in Virginia, South Carolina, Alabama, and Louisiana.

Member
University of Colorado, Denver Center for Combat Medicine and Battlefield (COMBAT) Research

The Center for Combat Medicine and Battlefield (COMBAT) Research is a lab within the University of Colorado, Denver that is dedicated to solving the U.S. military’s toughest medical challenges by leading high-impact research, education, and innovation. The center collaborates with government, academic, and industry partners to turn military medical gains into better healthcare for all. It focuses on combat and deployment-related medical research, leveraging over 100 years of combined military experience to address current military medicine research gaps and translate solutions to civilian communities. The center also emphasizes the importance of education and mentorship in advancing the next generation of military physicians and researchers.

Member
Texas Biomedical Research Institute

Texas Biomedical Research Institute (Texas Biomed) is a leading nonprofit biomedical research organization with more than 80 years of experience supporting the development of medical countermeasures for emerging and high-consequence infectious diseases. Texas Biomed provides comprehensive in-vitro and in-vivo preclinical research services supporting the discovery, development, and evaluation of vaccines, therapeutics, diagnostics, and other medical countermeasures from early discovery through preclinical proof-of-concept, efficacy, and translational research. Studies can be conducted under GLP or GLP-like quality frameworks, as appropriate to program stage and sponsor requirements, with integrated quality assurance and study compliance support. The Institute operates state-of-the-art ABSL-2, ABSL-3, as well as the only privately operated BSL-4 research facilities, together with the Southwest National Primate Research Center, enabling studies in small animal and nonhuman primate models under high-containment conditions. Texas Biomed has extensive expertise in virus propagation and characterization, antiviral and neutralization assays, molecular diagnostics, immunology, pathology, bioinformatics, animal model development, natural history studies, efficacy testing, pharmacology, and biomarker evaluation across a broad range of viral pathogens, including filoviruses, henipaviruses, arenaviruses, alphaviruses, flaviviruses, coronaviruses, hantaviruses, and other emerging and biodefense-relevant viruses. Pathogen expertise includes, but is not limited to, Ebola virus (EBOV), Sudan virus (SUDV), Bundibugyo virus (BDBV), Marburg virus (MARV), Nipah virus (NiV), Lassa virus (LASV), Junín virus (JUNV), Machupo virus (MACV), Western equine encephalitis virus (WEEV), Japanese encephalitis virus (JEV), West Nile virus (WNV), Dengue virus (DENV) and SARS-CoV-2. With decades of experience supporting Animal Rule programs and infectious disease research, Texas Biomed delivers integrated, high-quality preclinical solutions for government, industry, and academic partners developing medical countermeasures for BSL-2, BSL-3, and BSL-4 pathogens.

Member
University of Montana

The University of Montana (UM) is a flagship public research university located in Missoula, Montana. Established in 1893, UM offers a wide range of undergraduate and graduate programs, emphasizing research, creativity, and community engagement. With a commitment to academic excellence and public service, UM aims to transform lives through education and research, fostering a diverse and inclusive environment for its students.

Member
University at Buffalo (UB)

The University at Buffalo is a leading public research university and flagship of the SUNY System, recognized for its innovative research and commitment to societal impact. It aims to transform scientific and technological breakthroughs into global impact, addressing complex challenges through interdisciplinary collaboration.

Member
Cocrystal Pharma

Cocrystal Pharma is a clinical-stage biotechnology company specializing in the discovery and development of novel antiviral therapeutics for serious and chronic viral diseases such as influenza, COVID-19, hepatitis C, norovirus, and other respiratory viruses. The company leverages structure-based drug discovery technology and expertise in structural biology to design direct viral replication inhibitors with broad-spectrum activity. Its pipeline includes candidates in preclinical and clinical development, addressing unmet needs in antiviral medicine.

Member
University of California San Francisco

UC San Francisco is a leading university dedicated to advancing health worldwide through preeminent biomedical research, graduate-level education in the life sciences and health professions, and excellence in patient care. With a commitment to public service, UCSF aims to innovate health care approaches for vulnerable populations and train the next generation of health professionals.

Member
University of Texas Health Houston

UTHealth Houston is Texas’ resource for health care education, innovation, scientific discovery, and excellence in patient care. Since 1972, UTHealth Houston has been dedicated to educating the next generation of health care professionals, advancing biomedical research and public health, and providing exceptional care to communities. With half a century of experience, it is one of the nation’s most comprehensive academic health centers, committed to advancing the quality of human life through education, research, and clinical practice.

Member
SUNY Upstate Medical University

SUNY Upstate Medical University is a leading academic medical center in Central New York, dedicated to providing exceptional patient care, advancing medical research, and educating future healthcare professionals. As the region's only Level I trauma center and a Magnet recognized institution, Upstate is committed to delivering cutting-edge, life-saving treatments and fostering a compassionate, patient-centered environment. The university also plays a significant role in the community through outreach programs and is recognized as one of America's best large employers by Forbes.

Member
Washington State University

Washington State University (WSU) is a public research university dedicated to improving lives by serving the public good. With a commitment to unlocking possibilities, WSU empowers students, faculty, and others to create a world where all people can thrive. The university offers a diverse range of academic programs across its six campuses and is recognized for its high research activity and community engagement.

Member
University of California, Los Angeles

UCLA is a leading public research university located in Los Angeles, California. It is renowned for its commitment to the creation, dissemination, preservation, and application of knowledge for the advancement of global society. With a rich history of academic and athletic excellence, UCLA offers a comprehensive environment that supports both academic and personal growth. The university is dedicated to fostering innovation and making a significant impact on the world through groundbreaking research and transformative practices.

Member
VLP Therapeutics

VLP Therapeutics is a Maryland-based biotechnology company established in 2012, focused on developing preventative and therapeutic vaccines as well as targeted antibody agents for cancer, infectious diseases, autoimmune conditions, and neurological diseases. The company utilizes next-generation virus-like particle platforms, gene delivery systems, and structure-based antigen design to address unmet global medical needs. Its research pipeline includes vaccine candidates for malaria, dengue, COVID-19, and cancer immunotherapies. The organization is driven by a team with experience in vaccine R&D, clinical development, and collaborative partnerships with prominent academic and government institutions.

Member
Riptide Bioscience

Riptide Bioscience develops engineered peptides derived from host defense peptides found widely in nature. Riptide has developed an antimicrobial peptide, RP557, with extraordinary potential to address battlefield and complex traumatic wounds, both at the point of injury and during continuing care. RP557, once clinically translated will have the following favorable characteristics: • Broad spectrum antimicrobial activity thereby allowing empiric treatment, • Active against multidrug resistant organisms, including MRSA and P. aeruginosa, • Rapid bactericidal effect, • Less prone to pathogen resistance development, • Able to prevent biofilm formation, • Effective against established biofilm, • High Therapeutic Index, • Suppresses inflammatory responses (improves quality of healing; cosmesis and function), and • Accelerates wound healing.

Member
Kilobaser (MABEAL GmbH)

Kilobaser develops benchtop DNA and RNA synthesizer platforms that enable decentralized, on-demand synthesis of custom oligonucleotides for scientific research, diagnostics, and data storage. Their technology leverages microfluidic chips and cartridge-based reagent delivery, automating solid-phase synthesis processes in a user-friendly system. Kilobaser's mission is to democratize access to nucleic acid synthesis, supporting rapid prototyping, molecular biology workflows, and emerging fields like DNA data storage.

Member
Arizona State University

Arizona State University (ASU) is a comprehensive public research university known for its commitment to inclusivity, excellence, and societal impact. ASU is dedicated to advancing research-based solutions for global challenges, fostering strong leadership, and providing quality education accessible to all learners. The university is recognized for its innovative approach to education and its efforts in sustainability, research, and community service. ASU exemplifies a new prototype for the American public research university, focusing on excellence, broad access to quality education, and meaningful societal impact.

Member
Vanderbilt University School of Engineering

The Vanderbilt School of Engineering is a globally recognized academic and research institution dedicated to producing leaders and innovators in engineering. With a commitment to solving grand challenges, the school offers a diverse range of undergraduate and graduate programs across multiple engineering disciplines, fostering a culture of collaboration and excellence.

Member
Medical College of Wisconsin

The Medical College of Wisconsin (MCW) is dedicated to transforming healthcare through innovative education, research, and patient care. With a focus on academic medicine, MCW aims to improve the health of communities by fostering a collaborative learning environment that integrates medical education with groundbreaking research and comprehensive patient care.

Member
UC San Diego

The University of California San Diego (UC San Diego) is a leading public research university located in La Jolla, California with over $1.79B in research expenditures. Known for its innovative and interdisciplinary approach, UC San Diego offers a wide range of undergraduate, graduate, and professional programs across various fields. UC San Diego is recognized for its contributions to research and innovation, particularly in areas such as national defense, energy, data science, climate science, health innovation, and artificial intelligence. We also have the nation's first undergraduate program promoting projects and start up devoted to National Security Innovation (4iNS).

Member
University of Texas Health San Antonio

UT Health San Antonio is dedicated to educating the next generation of health care professionals, conducting innovative research, and providing high-quality patient care. With a commitment to community service, the institution aims to improve health outcomes in South Texas and beyond through its six schools and numerous degree programs.

Member
Indiana University

Indiana University is dedicated to building a better future through education, research, and community engagement. With a commitment to academic excellence, IU offers a diverse range of programs across its nine campuses, fostering an inclusive environment for over 90,000 students from around the world. IU is also at the forefront of groundbreaking research, particularly in areas such as brain health and Alzheimer's disease.

Member
The University of Texas Southwestern Medical Center

UT Southwestern Medical Center is a premier academic medical institution dedicated to advancing medical science and improving health care through excellence in education, research, and patient care. The center is renowned for its collaborative environment that fosters innovation and discovery, housing distinguished faculty including Nobel Laureates. UT Southwestern is recognized for its groundbreaking research, comprehensive educational programs, and commitment to patient care, serving millions annually across its facilities.

Member
Yale University

Yale University, founded in 1701, is dedicated to expanding and sharing knowledge, inspiring innovation, and preserving cultural and scientific information for future generations. It engages with local and global communities to promote cultural understanding and improve the human condition.

Member
Stanford University

Stanford University, founded nearly 150 years ago, is dedicated to educating students for lives of leadership and contribution with integrity. The university emphasizes advancing fundamental knowledge, cultivating creativity, and pioneering research for effective clinical therapies, while also focusing on societal impact and solutions.

Member
The University of Tennessee, Knoxville

The University of Tennessee, Knoxville is dedicated to advancing knowledge and understanding through research, scholarship, and creative work. The Office of Research, Innovation, and Economic Development supports faculty, staff, and students in developing competitive proposals and fostering a strong culture of research integrity, aiming to create a more just, prosperous, and sustainable world.

Member
University of California, Davis

UC Davis, founded in 1908, is a top-tier public university located in California, known for its commitment to education, research, and public service. It offers a diverse range of academic programs and is recognized for its contributions to agriculture, veterinary medicine, and sustainability. The university fosters a collaborative environment that encourages innovation and inclusivity, aiming to enhance the lives of its students and the broader community. Additionally, UC Davis is strategically located in the heart of Northern California, providing easy access to major attractions, including beaches, wine country, and national parks.

Member
Orlance, Inc.

Orlance, Inc. develops a needle-free, powdered vaccine delivery platform focused on DNA and RNA vaccines and immunotherapies. Its core technology, a dry-powder epidermal delivery device, targets the skin's immunologically active layers for effective, dose-sparing, and ambient-stable administration, eliminating the need for cold chain logistics. Orlance advances programs for infectious diseases and cancer immunotherapy, leveraging significant non-dilutive funding and strategic partnerships.

Member
University of Pittsburgh

The Center for Military Medicine Research (CMMR) at the University of Pittsburgh is dedicated to advancing medical research for wounded service members and their families. The center focuses on trauma, emergency, and critical care, leveraging the university's strengths in medical and engineering fields, and collaborating with Carnegie Mellon University's robotics and AI expertise. CMMR aims to enhance trauma care for warfighters and civilians, contributing to the defense innovation economy.

Member
Texas A&M Engineering Experiment Station (TEES)

The Texas A&M Engineering Experiment Station (TEES) is a state agency and part of the Texas A&M University System, dedicated to improving lives through engineering research, workforce development, and technology transition. TEES collaborates with industry, academia, and government to provide innovative solutions to global technical challenges.

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Moonrise Medical

Automated Portable Ultrasound for Rapid Vascular Assessment in Combat Casualty Care: Moonrise Medical Inc.

Moonrise Medical Inc. is developing an automated portable ultrasound system for rapid vascular assessment and real-time blood-flow monitoring in combat casualty care. The project is supported through MTEC Award No. 24-01-MPAI-149.

NIRSense

Rugged Physiological Monitoring for the Modern Warfighter: NIRSense

Under MTEC-21-10-NavyMultiTopic, NIRSense is advancing its tactical jet physiological monitoring technology for broader Navy applications. The project focuses on ruggedized, wireless physiological sensors that can provide reliable, real-time insight into warfighter health and performance in demanding operational environments.

Safi Biotherapeutics

Next-Generation Manufactured Red Blood Cells for Extended Battlefield Blood Supply: Safi Biotherapeutics

Safi Biotherapeutics is developing manufactured red blood cells (mRBCs) with extended shelf life to improve battlefield transfusion readiness and emergency trauma care.

Non-Invasive Glymphatic (GF) Monitoring and Recovery Optimization for Warfighter Cognitive Readiness

Applied Cognition is developing non-invasive glymphatic monitoring and recovery technologies to enhance warfighter cognitive readiness, resilience, and sleep recovery.

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