Revolution Biomanufacturing Inc.
Revolution Biomanufacturing Inc. (RBIx) is expanding beyond traditional CDMO Process/Analytical Development and Manufacturing services to pioneer distributed molecular manufacturing. A new class of digital biomanufacturing that enables the autonomous design, manufacture, quality verification, and deployment of Nucleic Acid therapeutics and molecular diagnostics at the point of need. By integrating AI-driven sequence optimization, enzymatic nucleic acid synthesis, Nanoparticle design and manufacturing (LNP & EV), closed-loop quality control, and field-deployable manufacturing platforms, RBIx is creating adaptive biological infrastructure capable of responding to emerging diseases, national security threats, and personalized medicine with unprecedented speed and flexibility.
Industries
Nr. of Employees
small (1-50)
Revolution Biomanufacturing Inc.
17 Briden St., Suite 111, Worcester, MA 01605
Revolution Biomanufacturing Inc. is currently seeking investment
Revolution Biomanufacturing Inc. is seeking a series-a investment in the range of 20m-50m
Products
RevSelect™
AI-Driven Sequence Optimization Platform
5' UTR optimization
3' UTR optimization
Codon optimization
Translation efficiency prediction
RNA stability optimization
Manufacturability optimization
Cell-specific expression optimization
AI assay design
Design-for-manufacturing algorithms
Applications:
mRNA
saRNA
circRNA
DNA templates
PCR primers
Diagnostic probes
CRISPR guides
RevSolve™
AI Design-to-Manufacture Platform
Automated process development
Digital batch records
Manufacturing optimization
Closed-loop process control
Predictive process analytics
Electronic release
AI manufacturing assistant
RevLoop™
Circular RNA Platform
Patent-pending circularization
Manufacturing process
Stabilization technology
Immune-silent constructs
High-expression circRNA
RevTarget™
Targeted Lipid Platform
AI lipid selection and patent-pending lipid library
Organ targeting
Cell and Tissue targeting
Protein corona engineering
Passive targeting
Active targeting through Drug Conjugation
Antibody-directed LNPs
Applications
Liver
Lung
Spleen
T cells
B cells
CAR-T
Gene editing
Lyophilized LNP Technology
Shelf-stable LNP
Cold-chain reduction
Pandemic stockpiling
Military deployment
SwiftScale™
Distributed Mobile RNA Manufacturing Units
Modular GMP
Rapid deployment
Military
Disaster response
Regional manufacturing
Cell & Gene Therapy
CAR-T
In vivo CAR
Gene editing
CRISPR support
mRNA delivery
DNA template production
RevSelect™
AI-Driven Sequence Optimization Platform 5' UTR optimization 3' UTR optimization Codon optimization Translation efficiency prediction RNA stability optimization Manufacturability optimization Cell-specific expression optimization AI assay design Design-for-manufacturing algorithms Applications: mRNA saRNA circRNA DNA templates PCR primers Diagnostic probes CRISPR guides
RevSolve™
AI Design-to-Manufacture Platform Automated process development Digital batch records Manufacturing optimization Closed-loop process control Predictive process analytics Electronic release AI manufacturing assistant
RevLoop™
Circular RNA Platform Patent-pending circularization Manufacturing process Stabilization technology Immune-silent constructs High-expression circRNA
RevTarget™
Targeted Lipid Platform AI lipid selection and patent-pending lipid library Organ targeting Cell and Tissue targeting Protein corona engineering Passive targeting Active targeting through Drug Conjugation Antibody-directed LNPs Applications Liver Lung Spleen T cells B cells CAR-T Gene editing Lyophilized LNP Technology Shelf-stable LNP Cold-chain reduction Pandemic stockpiling Military deployment
SwiftScale™
Distributed Mobile RNA Manufacturing Units Modular GMP Rapid deployment Military Disaster response Regional manufacturing
Cell & Gene Therapy
CAR-T In vivo CAR Gene editing CRISPR support mRNA delivery DNA template production
Services
Design and optimization of mRNA products, DNA templates, and process development for biologics including stability and translation efficiency improvements.
Upstream IVT
Downstream purification
TFF optimization
Oligo-dT purification
Sterile filtration
Process characterization
Scale-up
Technology transfer
Encapsulation of mRNA and other therapeutics with advanced lipid nanoparticles for improved delivery and bioavailability.
Scalable, regulatory-compliant production and fill-finish of mRNA drug substances and therapeutics.
Guidance and management for IND/BLA submissions, regulatory gap assessments, and oversight of outsourced development projects.
Analytical Development
PCR assays
RT-PCR assays
CRISPR diagnostics
LAMP assays
RPA assays
VT analytics
mRNA characterization
dsRNA analysis
Cap analysis
Poly(A) analysis
Fragment analysis
LNP characterization
Encapsulation efficiency
Potency assays
Stability studies
IND analytical packages
Circular RNA Platform
Manufacturing process
Stabilization technology
Immune-silent constructs
High-expression circRNA
Design and optimization of mRNA products, DNA templates, and process development for biologics including stability and translation efficiency improvements. Upstream IVT Downstream purification TFF optimization Oligo-dT purification Sterile filtration Process characterization Scale-up Technology transfer
Encapsulation of mRNA and other therapeutics with advanced lipid nanoparticles for improved delivery and bioavailability.
Scalable, regulatory-compliant production and fill-finish of mRNA drug substances and therapeutics.
Guidance and management for IND/BLA submissions, regulatory gap assessments, and oversight of outsourced development projects.
Analytical Development
PCR assays RT-PCR assays CRISPR diagnostics LAMP assays RPA assays VT analytics mRNA characterization dsRNA analysis Cap analysis Poly(A) analysis Fragment analysis LNP characterization Encapsulation efficiency Potency assays Stability studies IND analytical packages
Circular RNA Platform
Manufacturing process Stabilization technology Immune-silent constructs High-expression circRNA
Expertise Areas
- mRNA and Nucleic Acid therapeutics bioprocessing
- Personalized medicine manufacturing
- Distributed and closed loop manufacturing
- Regulatory compliance (IND, NDA, BLA)
Key Technologies
- In vitro transcription (IVT)
- Lipid nanoparticle formulation
- Custom DNA template engineering
- Mammalian and microbial cell culture
Key People
Jenny Zhao, MEng
VP, Operations
Changyuan Lu, PhD
Director, Nanotechnology and Drug Product Innovation
Manika Bhondeley, PhD
Director, Nucleic Acid Innovation
Jenny Zhao, MEng
VP, Operations
Changyuan Lu, PhD
Director, Nanotechnology and Drug Product Innovation
Manika Bhondeley, PhD
Director, Nucleic Acid Innovation