Texas Biomedical Research Institute
Texas Biomedical Research Institute is dedicated to pioneering and sharing scientific breakthroughs to protect global communities from infectious diseases. With over 80 years of experience, it combines high-level biocontainment labs, a National Primate Research Center, and a commitment to advancing diagnostics, vaccines, and therapies. The institute also emphasizes education and outreach, providing resources and programs to engage students and teachers in scientific research.
Industries
Nr. of Employees
large (251-1000)
Texas Biomedical Research Institute
P.O. Box 760549, San Antonio, TX 78245-0549
Patents
Cell culture media and methods for generating human alveolar macrophage-like cells
2024-12-24 • US-12173326-B2
View DetailsInvolucrin-driven retroviral expression cassettes encoding human immunodeficiency virus envelope glycoproteins
2020-08-25 • US-10751406-B2
View DetailsInvolucrin-driven retroviral expression cassettes encoding human immunodeficiency virus envelope glycoproteins
2017-08-15 • US-9730996-B2
View Details
Cell culture media and methods for generating human alveolar macrophage-like cells
2024-12-24 • US-12173326-B2
View DetailsInvolucrin-driven retroviral expression cassettes encoding human immunodeficiency virus envelope glycoproteins
2020-08-25 • US-10751406-B2
View DetailsInvolucrin-driven retroviral expression cassettes encoding human immunodeficiency virus envelope glycoproteins
2017-08-15 • US-9730996-B2
View DetailsProducts
CoDe: codon deoptimization tool
Computational tool to recode RNA/DNA sequences via codon-pair deoptimization to attenuate viruses by increasing underrepresented codon pairs without altering amino acid sequences.
Meta-Transcriptome Detector (MTD) pipeline
Bash-executed pipeline for joint analysis of host transcriptome and microbiome using bulk and single-cell RNA-seq; generates count matrices, graphs and summary outputs.
Cell culture media and methods for generating alveolar macrophage–like cells
In vitro differentiation protocol using a surfactant and cytokine mixture to convert blood-derived monocytes into alveolar macrophage–like cells that retain phenotype and function for extended culture.
Involucrin-driven retroviral expression cassette vaccine platform
Vaccine platform using differentiation-specific transcriptional regulatory elements to direct antigen expression in epithelial stem cell lineages for mucosal antigen presentation.
Monoclonal antibodies and antigen-binding fragments for SARS-CoV-2
Human monoclonal antibodies and fragments with broad neutralizing activity described for therapeutic use against SARS-CoV-2 infections.
Compositions and methods for treating Schistosoma infections
Patent-disclosed composition(s) and methods intended to treat Schistosoma infections.
CoDe: codon deoptimization tool
Computational tool to recode RNA/DNA sequences via codon-pair deoptimization to attenuate viruses by increasing underrepresented codon pairs without altering amino acid sequences.
Meta-Transcriptome Detector (MTD) pipeline
Bash-executed pipeline for joint analysis of host transcriptome and microbiome using bulk and single-cell RNA-seq; generates count matrices, graphs and summary outputs.
Cell culture media and methods for generating alveolar macrophage–like cells
In vitro differentiation protocol using a surfactant and cytokine mixture to convert blood-derived monocytes into alveolar macrophage–like cells that retain phenotype and function for extended culture.
Involucrin-driven retroviral expression cassette vaccine platform
Vaccine platform using differentiation-specific transcriptional regulatory elements to direct antigen expression in epithelial stem cell lineages for mucosal antigen presentation.
Monoclonal antibodies and antigen-binding fragments for SARS-CoV-2
Human monoclonal antibodies and fragments with broad neutralizing activity described for therapeutic use against SARS-CoV-2 infections.
Compositions and methods for treating Schistosoma infections
Patent-disclosed composition(s) and methods intended to treat Schistosoma infections.
Expertise Areas
- Infectious disease preclinical research
- Nonhuman primate model development and management
- Vaccine and therapeutic discovery and preclinical development
- Monoclonal antibody discovery and characterization
Key Technologies
- Biosafety level 4 (BSL-4) operations
- Biosafety level 3 (BSL-3) operations
- Nonhuman primate (NHP) models
- Telemetry for animal studies
Key People
Bruce Edwards
Executive Vice President, Finance & Administration and Chief Financial Officer
Dr. Cory Hallam
Executive Vice President, Applied Science and Innovation
Director, Southwest National Primate Research Center
Bruce Edwards
Executive Vice President, Finance & Administration and Chief Financial Officer
Dr. Cory Hallam
Executive Vice President, Applied Science and Innovation
Director, Southwest National Primate Research Center
News & Updates
Funding awarded to enhance research capabilities in HIV and TB.
A significant partnership aimed at improving epidemic preparedness.
Deployment of a tested vaccine to combat Marburg virus in Rwanda.
Funding awarded to enhance research capabilities in HIV and TB.
A significant partnership aimed at improving epidemic preparedness.
Deployment of a tested vaccine to combat Marburg virus in Rwanda.