Acute Pain
Acute Pain capability advances clinical tools and operational protocols for rapid pain assessment, multimodal analgesia, regional techniques, and minimally invasive interventions in combat and austere settings. Emphasis is on opioid‑sparing strategies, field‑capable monitoring, and decision support that reduce complications and speed return to duty.
Technical Challenges
Rapid, objective pain assessment in nonverbal, polytrauma, or altered‑consciousness casualties under noisy, chaotic conditions.
Safe, effective analgesia during prolonged field care with delayed evacuation and limited monitoring resources.
Opioid dependence, adverse effects, and limited availability of opioid alternatives suitable for austere environments.
Implementing regional anesthesia and continuous peripheral nerve blocks in prehospital and far‑forward settings.
Emerging Opportunities
Portable, validated biomarkers or physiologic monitors that correlate reliably with pain intensity in trauma.
Compact, stable non‑opioid formulations and local delivery systems with prolonged analgesic duration and minimal logistics burden.
Field‑ready ultrasound and catheter systems optimized for rapid, robust regional nerve blockade by non‑specialists.
Integrated decision‑support tools that guide analgesic selection, dosing, and transition of care across levels.
Current and Emerging Technologies in Acute Pain
Rapid assessment and monitoring
Wearable sensors, autonomic biomarker panels, pupillometry, and integrated physiologic analytics to provide objective pain indices when verbal reports are unavailable; designs prioritize ruggedness and low bandwidth telemetry.
Multimodal and non‑opioid pharmacologics
Novel NSAID formulations, NMDA receptor modulators, alpha‑2 agonists, gabapentinoids, and biologic modulators designed for stability in extreme temperatures and simplified dosing to minimize opioid use and respiratory risk.
Regional anesthesia and portable delivery
Compact ultrasound systems, nerve localization aids, long‑acting local anesthetic formulations, and catheter/infusion devices engineered for prolonged analgesia in prolonged field care and transport scenarios.
Neuromodulation and peripheral nerve stimulation
Portable transcutaneous electrical nerve stimulation (TENS), percutaneous nerve stimulators, and implantable short‑term devices that reduce nociceptive signaling without systemic effects, adapted for battlefield use.
Digital health, decision support, and telemedicine
Clinical decision algorithms, automated dosing calculators, remote ultrasound guidance, and secure teleconsult platforms that extend anesthesiology and pain expertise to forward providers and coordinate transitions of care.
Importance to Military Medicine
Combat casualty care
Effective acute pain control reduces physiologic stress, improves hemodynamic stability, and enables lifesaving interventions on the battlefield.
Prolonged and delayed evacuation
Sustained, safe analgesia is essential when evacuation is delayed, minimizing complications, infection risk, and long‑term disability during prolonged field care.
Operational readiness and return to duty
Rapid, effective pain management preserves function and accelerates recovery, reducing non‑deployable time and preserving unit readiness.
Austere environment resilience
Technologies tailored for heat, cold, vibration, and limited power extend safe analgesia options into far‑forward and maritime operations.
Alignment with the MTEC Mission
Directly supports MTEC priorities by accelerating translational research that moves field‑appropriate acute pain solutions from lab to point of injury.
Aligns with combat casualty care, regenerative medicine, and prolonged/distributed care portfolios to maintain force health and operational capability.
Promotes dual‑use impact: innovations reduce military morbidity and translate into civilian emergency, surgical, and disaster medicine benefits.
Dual-Use (Military + Civilian) Applications
Dual‑use applications include emergency department and prehospital analgesia protocols that lower opioid exposure and improve outcomes in civilian trauma.
Remote monitoring and tele‑mentored regional anesthesia benefit rural and disaster settings where specialist access is limited.
Portable analgesic delivery systems and long‑acting local formulations reduce hospital length of stay and support ambulatory surgical care pathways.
Data analytics and decision support created for military use can be repurposed for civilian pain registries, quality improvement, and AMR stewardship.
Explore MTEC Members with Acute Pain Capabilities
MTEC members bring cross‑disciplinary strengths — military clinical partners, academic pain researchers, medtech developers, and logistics experts — enabling rapid prototyping, clinical validation, and pathway to fielding.
Members offer capabilities in regulatory strategy, human factors, ruggedized device design, and clinical trials in relevant operational settings to de‑risk transition to use.
Explore member profiles to identify partners for joint projects, solicitation responses, and consortium‑enabled funding opportunities to accelerate acute pain innovations into practice.
101 Members with Acute Pain capabilities.
The University of Texas System is a leading public university system in the United States, dedicated to improving lives through education, health care, and research. With over 256,000 students enrolled across 14 institutions, the UT System is committed to providing affordable access to higher education and producing a skilled workforce to drive Texas's economy.
Georgia Southern University is a vibrant institution with over 26,100 students across three campuses in Statesboro, Savannah, and Hinesville. The university offers 132 degree programs at the associate, bachelor’s, master’s, and doctorate levels, emphasizing student success, community impact, and research excellence. With a commitment to inclusivity and engagement, Georgia Southern fosters a supportive environment for diverse learners, including military-affiliated and adult students. The university is dedicated to transforming lives through education and community engagement, aligning its programs with regional needs. Additionally, Georgia Southern provides accelerated pathways for students to fast-track their master's degrees, enhancing educational opportunities. The university also emphasizes career readiness and public impact research, preparing students for successful careers and contributing to community development.
Teleflex is a global provider of medical technologies designed to improve the health and quality of people's lives. The company focuses on purpose-driven innovation to empower healthcare professionals and enhance patient outcomes across various medical fields.
The National Foundation for Integrative Medicine (NFIM) is dedicated to transforming healthcare through innovative solutions and technologies. With a mission to shorten the technology transition cycle and improve health outcomes, NFIM focuses on patient care innovation and supports various populations, including veterans and clinicians, in accessing safer and more effective healthcare options.
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The University of Texas at San Antonio (UTSA) is dedicated to the advancement of knowledge through research, teaching, and community engagement. As a premier public research university, UTSA embraces multicultural traditions and serves as a catalyst for socioeconomic development, providing access to educational excellence and preparing citizen leaders for the global environment.
Auburn University Research & Economic Development is dedicated to advancing research and economic growth through a collaborative effort among its various colleges and departments. The organization focuses on fostering innovation, supporting faculty and student research, and facilitating partnerships with industry and government to address societal challenges and enhance the quality of life. Recent initiatives include the launch of the Team Science Series to promote interdisciplinary collaboration and the development of the Gulf Coast Engineering Research Station to address coastal environmental challenges.
Ethos Solutions specializes in rapid problem solving in dynamic environments through the Ethos IDEALs (Identification, Define, Engagement, Alignment, and Leveraging). Ethos leverages module working groups (or cells) consisting of Subject Matter Expert (SMEs) clinicians, training cadre, warriors, academics, and researchers able to rapidly identify and solve problem sets that require a grounded approach forged in austere and dynamic environments.
The Institute for Integrative & Innovative Research (I3R) at the University of Arkansas is dedicated to pioneering solutions to complex societal challenges through convergence research. With a mission to advance research excellence and stimulate economic development, I3R focuses on deploying innovations at scale through collaboration across various sectors, including academia, industry, and government.
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The University of Chicago is a prestigious urban research university committed to rigorous inquiry and intellectual freedom. Founded in 1890, it has produced numerous Nobel laureates and is known for its transformative education and groundbreaking research across various fields. The university fosters an inclusive and diverse learning environment, encouraging participation from all community members.
Harmac is a global contract design and manufacturing organization specializing in single-use medical devices. With over four decades of experience, Harmac provides comprehensive services including product design and development, advanced manufacturing, automation, value engineering, quality assurance, and packaging and sterilization. The company is known for its operational excellence, regulatory compliance, and commitment to sustainability and community engagement. Harmac operates facilities across the United States, Ireland, and Mexico, supporting customers worldwide and across a range of clinical applications. ISO 13485 Certified and FDA Registered.
Memsel is a biotechnology research and development company dedicated to enhancing health and combatting infections through advanced phage therapies and targeted delivery systems. The company aims to transform healthcare solutions across human, animal, and plant domains, addressing critical health challenges and antibiotic resistance.
Boston University is a major research institution committed to leading breakthroughs across various disciplines. The Office of Research supports and advances research excellence, fostering collaboration among researchers, industry partners, and government leaders to address significant societal challenges.
Ceria Therapeutics is a privately held biotechnology company focused on developing novel RNA-based drug products for the treatment of acute and chronic inflammatory diseases. The company aims to address high unmet medical needs by targeting the root causes of dysregulated inflammation, thereby restoring natural healing processes and improving patient outcomes. Its core technology leverages nanoparticle delivery of microRNA therapeutics to modulate inflammatory pathways. Ceria operates research and development facilities in Tucson, Arizona and Aurora, Colorado, and collaborates with leading academic and clinical partners to advance preclinical and clinical programs for conditions such as acute lung injury, diabetic foot ulcers, and inflammatory bowel disease.
Baylor University is a preeminent Christian research university committed to addressing the world's most meaningful challenges through top-tier research and scholarship. Recognized as an R1 research institution, Baylor focuses on infusing its distinct Christian mission into its research initiatives, fostering a commitment to excellence and innovation.
Evren Technologies is a bioelectronic medical device company focused on transforming the treatment of Post Traumatic Stress Disorder (PTSD) through non-invasive Vagal Nerve Stimulation (VNS) technologies. Their mission is to empower patients to rise above PTSD and improve their lives with innovative solutions.
Kaléo is a global leader in drug-delivery device technology and auto-injector innovation, providing millions of patients with security and peace of mind. Our patented Aerio™ platform, with unmatched capabilities and human factors engineering, powers our portfolio of auto-injector products, as well as products under development for third parties.
Thornhill Medical specializes in advanced medical technologies for critical care, anesthesia, respiratory therapy, and vascular diagnostics. Their core offerings address clinical needs in austere, emergency, battlefield, and transport environments, enabling mobile and integrated life support, portable anesthesia, and precise non-invasive control and measurement of blood gases. With significant expertise in both product engineering and translational clinical research, the company supports deployments worldwide, collaborates with military and civilian partners, and contributes to innovation in healthcare delivery and device interoperability.
TRI Medical, Inc. develops and supplies educational simulation models and training services to enhance the diagnostic and manual skills of healthcare professional students and new graduates. The company focuses on providing real-time, psychomotor feedback tools for medical education programs and healthcare organizations, aiming to improve confidence, self-efficacy, and diagnostic accuracy prior to clinical practice.
Solventum is a healthcare company dedicated to enabling better, smarter, and safer healthcare solutions. With a legacy of innovation, Solventum focuses on improving patient outcomes through advanced medical technologies, oral care solutions, health information technology, and purification and filtration systems.
The UT Arlington Research Institute (UTARI) specializes in applying cutting-edge technologies to real-world engineering problems. Our collaborative endeavors reflect a commitment to excellence, integrity, and respect for all, bringing economic growth and fulfillment to our families, business partners, university, and community.
The University of Maryland, Baltimore (UMB) is Maryland’s public health, law, and human services university. It is dedicated to improving the human condition and serving the public good through education, research, clinical care, and service. UMB is the founding campus of the University System of Maryland and offers a wide range of professional degrees in health care, human services, and law.
The University of North Carolina Wilmington (UNCW) is a top doctoral and research institution located in Wilmington, North Carolina. Established in 1947, UNCW has grown to serve nearly 18,000 students and employs about 2,500 staff. The university is dedicated to providing a powerful academic experience that fosters creative inquiry, critical thinking, and thoughtful expression in a beautiful coastal setting. UNCW is committed to educational excellence, community engagement, and global connections, making it a vibrant part of the southeastern North Carolina community. UNCW also emphasizes the importance of freedom of expression and mutual respect within its diverse community.
The University of Missouri-Kansas City (UMKC) is dedicated to transforming today's learners into tomorrow's leaders through innovative education, research, and community engagement. With over 125 academic programs, UMKC fosters a diverse and inclusive environment that empowers students to achieve their goals and make a positive impact in their communities.
Mayo Clinic is the largest integrated, not-for-profit medical group practice in the world, dedicated to providing high-quality, patient-centered care. With a history of innovation spanning nearly 150 years, Mayo Clinic is committed to transforming healthcare through research, education, and compassionate care, ensuring that the best possible treatment is available to everyone.
ARMR Sciences, Inc. is a biotechnology company dedicated to ending the fentanyl crisis and defending against synthetic drug threats through American innovation. The company is pioneering scalable, preventative immunotherapies to protect individuals before exposure to lethal synthetic drugs like fentanyl, moving beyond reactive treatments to address the root causes of overdose deaths. ARMR's technology is supported by foundational licenses from the Department of Defense and aligns with federal health and defense agencies. The multidisciplinary team brings significant experience from leading institutions and companies such as MindMed, iBio, Ridgeback Biotherapeutics, Scripps Research, Boston Children’s Hospital, Harvard Medical School, and more. United in their vision to save lives, ARMR is committed to providing lasting protection and solving the overdose crisis for millions in need.
Temple University is Philadelphia’s only public university and a global center of academic excellence. It is classified as an R1 institution, indicating very high research activity, and offers over 600 academic programs across 17 diverse schools and colleges. The university is committed to providing accessible education that fosters positive change and prepares students to become leaders in their fields. Additionally, Temple emphasizes a vibrant campus life enriched by arts, culture, and a commitment to diversity and inclusivity. The university also promotes a tobacco-free environment to enhance the health and well-being of its community. Temple's athletics program further enhances student life, with 19 varsity teams competing at the NCAA Division I level, fostering school spirit and community engagement.
The Office of Sponsored Projects Administration (OSPA) at the University of Kentucky is dedicated to transforming tomorrow by streamlining grants and contracts. OSPA provides essential services to faculty and staff, including assistance with proposal preparation, award negotiation, and compliance with sponsor policies.
Southwest Research Institute (SwRI) is a nonprofit research and development organization that provides independent, premier services to government and industry clients. Founded in 1947, SwRI is committed to advancing science and technology to benefit humanity, focusing on innovative solutions that improve human health and safety. With a diverse range of technical divisions, SwRI addresses complex challenges in various fields including mechanical engineering, materials, aerospace, automotive, biomedical, and more.
Combat SNS (Combat Medical Consulting, CMC) is a Service-Disabled Veteran-Owned Small Business (SDVOSB) dedicated to bridging the gap between innovative medical technologies and operational end users in the Department of Defense (DoD), Department of Veterans Affairs (VA), and other government agencies. With over 30 years of expertise in direct sales, government procurement, and market integration, CMC specializes in high-quality medical supply distribution, consulting, and product development. Their mission is to accelerate the adoption of advanced medical solutions, ensuring best-value procurement and broad impact across public health and defense sectors. CMC is recognized for its comprehensive approach, from market research and product validation to training, certification, and field deployment.
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The Southwest Texas Regional Advisory Council (STRAC) is dedicated to developing, implementing, and maintaining a regional trauma and emergency healthcare system for the 22 counties in Trauma Service Area – P. STRAC aims to reduce death and disabilities related to trauma, disaster, and acute illness through well-coordinated emergency response systems, striving to be a model for emergency healthcare in the United States.
North American Rescue (NAR) is dedicated to decreasing preventable death by providing the most effective and highest quality mission critical medical products to military, federal agencies, civilian law enforcement, EMS, and pre-hospital life savers. NAR designs, develops, and tests products based on Tactical Combat Casualty Care (TCCC) guidelines, ensuring they meet the evolving needs of first responders and healthcare providers. NAR is committed to quality, with a focus on American-made products and adherence to the highest industry standards.
Macro Biologics, Inc. is dedicated to designing, patenting, and producing macro biologics, which are large molecule biologics with both physical properties and functional activities. These biologics are composed of natural building blocks, such as amino acids or carbohydrates, and are designed to degrade back into their natural components, making them environmentally friendly. The company aims to address significant global challenges, such as antibiotic resistance and pollution, by providing biologics that are safe for both people and the environment. Macro Biologics is committed to the highest standards of science, medicine, and business, with a focus on healthcare applications.
NANOMEDICINE MANUFACTURING LABORATORY Nanomedicine Manufacturing Laboratory (NML) is a research and development laboratory specializing in nanomaterials and biomaterials for imaging, oxygen delivery, and drug delivery, with a core emphasis on scalable manufacturing and Quality-by-Design (QbD). More informaiton about NML: https://www.duq.edu/research/faculty-research/nanomedicine-lab/nanomed-lab-research.php Led by Dr. Jelena M. Janjic, the Nanomedicine Manufacturing Laboratory develops colloidal nanosystems and implantable biomaterials that support molecular imaging modalities, including magnetic resonance imaging (MRI) and near-infrared fluorescence; biosensing, drug delivery; oxygen delivery; and theranostic nanomaterials, used for local and parenteral administration or as implantable biomaterials. A major barrier to the advancement of nanotechnology-based therapeutics is not conceptual innovation but manufacturability, cost, and quality control. The Nanomedicine Manufacturing Laboratory addresses these challenges by incorporating manufacturing process design, scalability, and quality control at the earliest stages of material design. Over the past decade, the laboratory has established robust, reproducible, and cost-effective nanomedicine manufacturing methods by applying QbD frameworks, enabling reliable scale-up and controlled performance. The laboratory’s work is supported by the U.S. Air Force, the Congressionally Directed Medical Research Programs (CDMRP), and ARPA-H through collaborative programs spanning academia, industry, and government. The Nanomedicine Manufacturing Laboratory operates at the intersection of materials science, manufacturing, and translational medicine, with a focus on developing innovative nanomedicines and biomaterials that translate into accessible, cost-effective future treatments for civilian and military medical needs.
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The University of Minnesota's Research and Innovation Office (RIO) serves as a central resource for conducting, managing, and sponsoring research. It aims to facilitate collaborative research that addresses complex problems and promotes innovations that improve lives. RIO oversees research compliance and administration, fostering a culture of integrity and ethical practices in research. Additionally, RIO is committed to enhancing research capacity through various funding opportunities and strategic initiatives, including the management of specialized facilities for biocontainment research.
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New York University (NYU) is a global university that connects talented and ambitious individuals in some of the world's greatest cities. Its mission is to be a top-quality institution, providing a diverse range of academic programs and opportunities for students to engage with the world's challenges. NYU is committed to fostering innovation and entrepreneurship, and it emphasizes diversity, equity, and inclusion in its educational mission. Founded in 1831, NYU has evolved to become a leader in higher education, with a commitment to accessibility and a diverse student body. NYU offers a wide array of academic programs, including accelerated studies and online education, catering to the needs of a global student population.
Northwestern University is a prestigious institution dedicated to fostering a diverse and inclusive environment, promoting academic excellence, and engaging in impactful research. With campuses in Evanston, Chicago, and Doha, Qatar, Northwestern emphasizes global engagement and community involvement, preparing students to tackle complex challenges through interdisciplinary collaboration and innovative thinking.
The University of Iowa is dedicated to providing a comprehensive educational experience that fosters academic excellence, research opportunities, and a vibrant student life. With a commitment to accessibility and inclusivity, the university aims to prepare its students for success in various fields while promoting a supportive community.
Case Western Reserve University is dedicated to solving the biggest issues of today and tomorrow through innovative research and education. With a commitment to experiential learning, the university offers a wide range of programs and opportunities for students to engage in research, internships, and community service, all within a vibrant campus located in Cleveland, Ohio.
The University of Alaska Fairbanks (UAF) is a Land, Sea, and Space Grant university and an international center for research, education, and the arts, emphasizing the circumpolar North and its diverse peoples. UAF integrates teaching, research, and public service as it educates students for active citizenship and prepares them for lifelong learning and careers.
New Jersey Institute of Technology (NJIT) is a leading public research university dedicated to providing students with a world-class education in STEM fields and beyond. With a commitment to academic excellence, NJIT prepares students to be leaders in the most in-demand fields through innovative programs, expert faculty, and extensive research opportunities. NJIT is recognized for its affordability and return on investment, making it a top choice for students seeking a quality education. NJIT is also ranked among the top public universities in the nation, known for its diverse student body and commitment to fostering an inclusive environment.
CRG Defense is a secure, scalable defense company, purpose-built for rapid deployment of defense and dual-use technologies into field-ready systems. From prototype to production — CRG Defense delivers mission-critical innovation across systems, materials, power, infrastructure, and medtech. Our Vision is a world where advanced defense capabilities strengthen national security, empower warfighters, and preserve freedom through innovation. Our Mission is to design, develop, and deliver solutions that serve the warfighter, support our partners, and scale to meet the future of national defense. Our Technology Innovation Division develops solutions in advanced aerospace, materials, AI, energy systems, and human health technologies, transforming emerging science into mission-ready capabilities.
The University of Arkansas for Medical Sciences Office of Research and Sponsored Programs (ORSP) is dedicated to supporting UAMS faculty in acquiring, performing, and administering projects funded by external sources. The ORSP ensures compliance with policies, negotiates award terms, liaises between investigators and sponsors, and manages subcontracts.
Founded by Thomas Jefferson in 1819, the University of Virginia is a prestigious public university that emphasizes the advancement of human knowledge, education of leaders, and cultivation of an informed citizenry. It is recognized for its commitment to academic excellence, vibrant student life, and a strong alumni network, making it one of the top public universities in the United States.
The University of Missouri is dedicated to advancing research, innovation, and impact through a comprehensive support system for faculty, students, and staff. It aims to foster collaboration, enhance economic development, and promote entrepreneurship, while ensuring compliance with research regulations and ethical standards. The university also emphasizes the importance of interdisciplinary partnerships and provides resources to support veteran entrepreneurs through programs like the Entrepreneurship Bootcamp for Veterans.
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The University of Nebraska Medical Center (UNMC) is dedicated to transforming lives through premier educational programs, innovative research, and extraordinary patient care. Founded in 1869, UNMC is a leader in health sciences education and research, serving as a vital resource for Nebraska and beyond.
The University of Georgia (UGA) is dedicated to facilitating instruction, scholarly and creative activity, and research collaborations across disciplines. UGA is a leader in research-based products and innovation, significantly impacting the state of Georgia and beyond through its extensive research initiatives and academic programs.
MassBiologics, part of UMass Chan Medical School, is the only nonprofit, FDA-licensed manufacturer of vaccines and biologics in the United States. With over 100 years of experience, it is dedicated to improving public health through the research, development, and production of biologic products, including vaccines and monoclonal antibodies.
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The Medical University of South Carolina (MUSC) is South Carolina’s premier biomedical research institution, dedicated to advancing health through innovative research, education, and clinical care. With over $300 million in research funding and a commitment to addressing pressing health challenges, MUSC fosters collaboration among faculty, staff, and community partners to translate scientific discoveries into impactful health solutions. The South Carolina Clinical & Translational Research Institute (SCTR) at MUSC supports innovative research across the translational spectrum, from basic science to population health, including patient-centered and community-engaged research.
Lumeto is a leader in healthcare simulation using AI and immersive technologies. Its simulation platform is used for training, skills assessment and workforce development in the healthcare, safety, and defense sectors. Their flagship platform, InvolveXR, leverages AI to deliver scalable, customizable, and competency-mapped simulations accessible from anywhere. Lumeto's mission is to revolutionize healthcare and workforce preparedness by providing realistic, data-driven, and engaging learning experiences that enhance decision-making, communication, and patient safety. The company partners with leading academic institutions, healthcare organizations, and technology providers globally, and is recognized for its evidence-based, adaptable, and inclusive approach to training the next generation of first responders. Lumeto is at the forefront of innovation with AI-driven virtual patients, customizable learning modules, and partnerships that extend into remote and space healthcare training. Recent advancements include the launch of industry-first customizable AI non-patient characters, a fully customizable AI-driven conversational system for healthcare simulation in VR, and scalable self-directed learning capabilities. Lumeto's InvolveXR platform is recognized for its flexibility, fidelity, and scalability, supporting both asynchronous and synchronous training, and is validated by research demonstrating significant improvements in clinical training outcomes.
The University of Florida is a leading public university that fosters innovation, education, and research. With a commitment to excellence, the university provides a diverse and inclusive environment for students, faculty, and staff, driving impactful discoveries and community engagement.
NeoMatrix Therapeutics is a clinical-stage company dedicated to developing novel, bioactive peptides aimed at preventing injury progression and enhancing tissue healing, particularly in severe burn cases. Founded by Dr. Richard A. Clark, the company focuses on innovative therapies that significantly improve the quality of life and clinical outcomes for burn patients.
The UCI Office of Research is dedicated to supporting and enhancing the creative and scholarly activities of UCI faculty and researchers. It provides central administrative support for research programs, ensuring compliance with regulations and fostering an environment conducive to research and innovation.
Home Base is a national nonprofit organization dedicated to healing the invisible wounds of war for Veterans, Service Members, Military Families, and Families of the Fallen. Founded by Massachusetts General Hospital and the Boston Red Sox, Home Base provides world-class clinical care, wellness, education, and research at no cost to participants, regardless of their era of service, discharge status, or geographical location. The organization operates the first and largest private-sector clinic in the nation devoted to treating post-traumatic stress, traumatic brain injury, and other related issues. Home Base has served over 45,000 individuals across 50 U.S. states, 13 countries, and 5 territories, all at no out-of-pocket cost.
The Clemson University Research Foundation (CURF) is dedicated to advancing the research enterprise at Clemson University by connecting faculty and students with industry partners. CURF facilitates the commercialization of university technologies, supports research collaboration, and promotes innovation through various funding and support programs.
Virginia Tech is a leading research institution dedicated to improving the quality of life and the human condition through education, research, and community engagement. With a commitment to its motto, 'Ut Prosim' (That I May Serve), Virginia Tech fosters a collaborative environment that integrates technology into all disciplines, preparing scholars to be leaders and problem-solvers.
OsteoCure Therapeutics, a Duke University spinout and Johnson & Johnson JLABS company based in Durham, North Carolina, is developing OCTA1, a first-in-class injectable therapy designed to accelerate bone healing while simultaneously reducing pain. OCTA1 is a device led combination product that is composed of a hyaluronic acid scaffold with sustained-release microgels that deliver adenosine, a naturally occurring molecule critical for bone regeneration and pain modulation. Preclinical studies have demonstrated significant improvements in fracture healing and functional recovery, with strong statistical significance in both bone repair and analgesia. For civilian medicine, OCTA1 offers a minimally invasive, opioid-sparing solution for treating fusions, fractures, and other orthopedic trauma, enabling faster recovery for patients from athletes to older adults. In military medicine, the technology addresses critical needs in combat casualty care and training-related musculoskeletal injuries such as stress fractures, by providing a deployable, shelf-stable, and rapidly administered intervention that improves healing outcomes and reduces downtime, ultimately enhancing force readiness while also benefiting the long-term musculoskeletal health of veterans
Velico® is a private, clinical stage medical technology company headquartered in Beverly, Massachusetts, dedicated to reducing preventable death from bleeding through innovative blood and plasma products. Their flagship product, FrontlineODP™, is a novel dry plasma manufacturing system designed for rapid rehydration and transfusion in emergency settings, aiming to improve patient access to life-saving treatments.
Vascular BioSciences is a biopharmaceutical and medical device company focused on developing targeted therapeutics, minimally invasive interventional devices, and advanced molecular diagnostics for cardiovascular, pulmonary, and inflammatory diseases. The company leverages targeted peptide drug delivery, endovascular tissue sampling, molecular profiling, and bioinformatics to advance personalized medicine for difficult-to-treat diseases. Its operations span California and North Carolina with expertise in biologics, device engineering, and translational research.
LSU Health Sciences Center New Orleans is dedicated to educating future health professionals and scientists, advancing research, and providing exceptional healthcare. With six professional schools and numerous affiliated hospitals, LSUHSC-NO aims to improve health outcomes and address health equity challenges in Louisiana.
The University of Texas Permian Basin (UTPB) offers a modern, affordable education in the heart of West Texas, focusing on student success and community impact. With a commitment to providing a diverse range of undergraduate and graduate programs, UTPB aims to empower students to achieve their academic and career goals while contributing positively to the region. UTPB also emphasizes professional development through innovative programs like the Coursera Career Academy and the Impact Behavioral Health Scholarship, which covers tuition and fees for graduate students in specific programs.
Relevium Medical is a pharmaceutical company based in Ireland and the US, founded in 2019 as a spin-out from the University of Galway’s BioInnovate Programme, the only European affiliate of Stanford BioDesign. With support from Y Combinator, Enterprise Ireland and the European Innovation Council, the company is developing novel hydrogel-based therapeutics for chronic disorders, leveraging natural biopolymers and active agents for targeted, long-lasting treatment. Relevium has a world-class clinical advisory board and a growing pipeline including products for osteoarthritis, painful bladder, neurogenic bladder, & trauma wound infections. To date the company has secured a total of $8 million non-dilutive funding and private seed investment.
Emergent BioSolutions is dedicated to developing, manufacturing, and delivering medical countermeasures that address public health threats. With a mission to protect and enhance life, the company focuses on innovative vaccines and therapeutics to combat critical health challenges, including the ongoing opioid crisis.
Northeastern University is a global research university founded in 1898, renowned for its experiential learning model, high-impact research, and deep partnerships. The university emphasizes innovative teaching and research that engage students, faculty, and alumni in solving real-world problems, fostering a dynamic and inclusive community across its 13 campuses worldwide.
The University of Montana (UM) is a flagship public research university located in Missoula, Montana. Established in 1893, UM offers a wide range of undergraduate and graduate programs, emphasizing research, creativity, and community engagement. With a commitment to academic excellence and public service, UM aims to transform lives through education and research, fostering a diverse and inclusive environment for its students.
The University at Buffalo is a leading public research university and flagship of the SUNY System, recognized for its innovative research and commitment to societal impact. It aims to transform scientific and technological breakthroughs into global impact, addressing complex challenges through interdisciplinary collaboration.
ZOLL Medical Corporation, a subsidiary of Asahi Kasei, is a global leader in developing and marketing medical devices and software solutions aimed at advancing emergency care and improving patient outcomes. Founded in 1980 and named after Dr. Paul Zoll, the company is renowned for its innovative technologies in defibrillation, cardiac monitoring, and other critical care solutions. ZOLL is committed to enhancing clinical and operational efficiencies, supporting healthcare professionals and lay rescuers worldwide in addressing serious cardiopulmonary and respiratory conditions.
UC San Francisco is a leading university dedicated to advancing health worldwide through preeminent biomedical research, graduate-level education in the life sciences and health professions, and excellence in patient care. With a commitment to public service, UCSF aims to innovate health care approaches for vulnerable populations and train the next generation of health professionals.
UTHealth Houston is Texas’ resource for health care education, innovation, scientific discovery, and excellence in patient care. Since 1972, UTHealth Houston has been dedicated to educating the next generation of health care professionals, advancing biomedical research and public health, and providing exceptional care to communities. With half a century of experience, it is one of the nation’s most comprehensive academic health centers, committed to advancing the quality of human life through education, research, and clinical practice.
Oridivus is pioneering the development of the first FDA-approved oral wound healing therapy, with a mission to transform pediatric oral health outcomes. The company addresses critical unmet needs in oral surgery by accelerating healing, reducing pain, and minimizing opioid dependency, especially in young patients. Oridivus leverages advanced biomaterials and immunomodulatory compounds to provide faster, safer, and more effective recovery for procedures such as wisdom tooth extractions, cleft palate repairs, and oral trauma. Their vision is to improve quality of life for children and young adults, break the cycle of opioid dependency, and set new standards in oral wound care.
SUNY Upstate Medical University is a leading academic medical center in Central New York, dedicated to providing exceptional patient care, advancing medical research, and educating future healthcare professionals. As the region's only Level I trauma center and a Magnet recognized institution, Upstate is committed to delivering cutting-edge, life-saving treatments and fostering a compassionate, patient-centered environment. The university also plays a significant role in the community through outreach programs and is recognized as one of America's best large employers by Forbes.
Document Storage Systems, Inc. (DSS, Inc.) is a leading health information technology (HIT) software development and systems integration company with over 30 years of experience. DSS delivers innovative, secure, and efficient healthcare technology solutions and services used daily by thousands of clinicians and administrative staff nationwide, across federal, private, and public healthcare sectors. The company is dedicated to improving productivity and healthcare delivery, with a strong focus on digital transformation, interoperability, regulatory compliance, and above all, patient care. DSS is recognized for its deep expertise in modernizing legacy systems, supporting the Department of Veterans Affairs, and delivering solutions that enhance provider performance and patient outcomes. DSS is a member of the Open Source Electronic Health Record Agent (OSEHRA) and a founder of the VistA Extension Hub, fostering open source collaboration in healthcare IT. The company is also known for its rapid nationwide implementations, strategic partnerships, and a legacy of enabling significant cost savings and operational efficiencies for the VA and other healthcare organizations. DSS has been repeatedly recognized in the Healthcare Informatics Top 100 list of leading healthcare IT vendors, reflecting its industry impact and growth.
Washington State University (WSU) is a public research university dedicated to improving lives by serving the public good. With a commitment to unlocking possibilities, WSU empowers students, faculty, and others to create a world where all people can thrive. The university offers a diverse range of academic programs across its six campuses and is recognized for its high research activity and community engagement.
Pressure Medical develops advanced medical devices focused on severe hemorrhage control and trauma care, particularly for military and high-risk civilian environments. The company specializes in smart pneumatic and junctional tourniquets designed for rapid and effective bleeding control in emergency situations, emphasizing ease of use, minimal training requirements, and patient limb preservation. With multiple issued patents and collaborations with government and defense agencies, Pressure Medical aims to enhance combat medical care and improve survival outcomes through innovative biomedical engineering.
UCLA is a leading public research university located in Los Angeles, California. It is renowned for its commitment to the creation, dissemination, preservation, and application of knowledge for the advancement of global society. With a rich history of academic and athletic excellence, UCLA offers a comprehensive environment that supports both academic and personal growth. The university is dedicated to fostering innovation and making a significant impact on the world through groundbreaking research and transformative practices.
Riptide Bioscience develops engineered peptides derived from host defense peptides found widely in nature. Their focus is on creating peptide-based therapeutics for cancer, inflammatory diseases, and microbial infections, especially those resistant to conventional treatments. The company advances both preclinical and early-stage clinical programs, collaborates with academic partners and government agencies, and holds patents for its engineered peptide design technologies.
Rx Bandz is dedicated to developing innovative, next-generation auto-injectors and life-saving formulations that provide simple solutions for patients, first responders, and the military. Their mission is to enhance the delivery of injectable medications, ensuring accessibility and ease of use for anyone, anytime, anywhere.
Arizona State University (ASU) is a comprehensive public research university known for its commitment to inclusivity, excellence, and societal impact. ASU is dedicated to advancing research-based solutions for global challenges, fostering strong leadership, and providing quality education accessible to all learners. The university is recognized for its innovative approach to education and its efforts in sustainability, research, and community service. ASU exemplifies a new prototype for the American public research university, focusing on excellence, broad access to quality education, and meaningful societal impact.
The Vanderbilt School of Engineering is a globally recognized academic and research institution dedicated to producing leaders and innovators in engineering. With a commitment to solving grand challenges, the school offers a diverse range of undergraduate and graduate programs across multiple engineering disciplines, fostering a culture of collaboration and excellence.
The Medical College of Wisconsin (MCW) is dedicated to transforming healthcare through innovative education, research, and patient care. With a focus on academic medicine, MCW aims to improve the health of communities by fostering a collaborative learning environment that integrates medical education with groundbreaking research and comprehensive patient care.
UT Health San Antonio is dedicated to educating the next generation of health care professionals, conducting innovative research, and providing high-quality patient care. With a commitment to community service, the institution aims to improve health outcomes in South Texas and beyond through its six schools and numerous degree programs.
Indiana University is dedicated to building a better future through education, research, and community engagement. With a commitment to academic excellence, IU offers a diverse range of programs across its nine campuses, fostering an inclusive environment for over 90,000 students from around the world. IU is also at the forefront of groundbreaking research, particularly in areas such as brain health and Alzheimer's disease.
UT Southwestern Medical Center is a premier academic medical institution dedicated to advancing medical science and improving health care through excellence in education, research, and patient care. The center is renowned for its collaborative environment that fosters innovation and discovery, housing distinguished faculty including Nobel Laureates. UT Southwestern is recognized for its groundbreaking research, comprehensive educational programs, and commitment to patient care, serving millions annually across its facilities.
SereNeuro Therapeutics is focused on discovering and developing advanced therapies for pain relief, emphasizing non-opioid solutions. The company is committed to pioneering innovative treatments to address unmet medical needs in pain management.
Yale University, founded in 1701, is dedicated to expanding and sharing knowledge, inspiring innovation, and preserving cultural and scientific information for future generations. It engages with local and global communities to promote cultural understanding and improve the human condition.
Stanford University, founded nearly 150 years ago, is dedicated to educating students for lives of leadership and contribution with integrity. The university emphasizes advancing fundamental knowledge, cultivating creativity, and pioneering research for effective clinical therapies, while also focusing on societal impact and solutions.
The University of Tennessee, Knoxville is dedicated to advancing knowledge and understanding through research, scholarship, and creative work. The Office of Research, Innovation, and Economic Development supports faculty, staff, and students in developing competitive proposals and fostering a strong culture of research integrity, aiming to create a more just, prosperous, and sustainable world.
The Geneva Foundation is a 501(c)3 nonprofit established in 1993, dedicated to advancing military medicine through research, development, and education. With a commitment to ensuring optimal health for service members and the communities they serve, Geneva collaborates with various partners to drive innovative medical research and improve healthcare outcomes.
UC Davis, founded in 1908, is a top-tier public university located in California, known for its commitment to education, research, and public service. It offers a diverse range of academic programs and is recognized for its contributions to agriculture, veterinary medicine, and sustainability. The university fosters a collaborative environment that encourages innovation and inclusivity, aiming to enhance the lives of its students and the broader community. Additionally, UC Davis is strategically located in the heart of Northern California, providing easy access to major attractions, including beaches, wine country, and national parks.
SIENI Holdings is a pioneering biotech company focused on developing localized therapies for the treatment of musculoskeletal conditions, including inflammation, infection, pain, and the prevention of post-surgical complications. Their mission is to enable faster healing and safer recovery by minimizing systemic drug exposure through their innovative AEGEAL platform, which delivers FDA-approved drugs directly to the site of injury or surgery. SIENI's vision is to provide versatile, precise, and bioresponsive solutions adaptable across orthopedic, trauma, burn, and veterinary applications, addressing a significant global health burden and market opportunity.
The Center for Military Medicine Research (CMMR) at the University of Pittsburgh is dedicated to advancing medical research for wounded service members and their families. The center focuses on trauma, emergency, and critical care, leveraging the university's strengths in medical and engineering fields, and collaborating with Carnegie Mellon University's robotics and AI expertise. CMMR aims to enhance trauma care for warfighters and civilians, contributing to the defense innovation economy.
The Texas A&M Engineering Experiment Station (TEES) is a state agency and part of the Texas A&M University System, dedicated to improving lives through engineering research, workforce development, and technology transition. TEES collaborates with industry, academia, and government to provide innovative solutions to global technical challenges.

Safi Biotherapeutics
Next-Generation Manufactured Red Blood Cells for Extended Battlefield Blood Supply: Safi Biotherapeutics
Safi Biotherapeutics is developing manufactured red blood cells (mRBCs) with extended shelf life to improve battlefield transfusion readiness and emergency trauma care.
Non-Invasive Glymphatic (GF) Monitoring and Recovery Optimization for Warfighter Cognitive Readiness
Applied Cognition is developing non-invasive glymphatic monitoring and recovery technologies to enhance warfighter cognitive readiness, resilience, and sleep recovery.
Moberg Analytics
Moberg Analytics – Advanced Brain Monitoring & Critical Care Informatic
Moberg’s platform unifies brain monitoring data for faster, precise treatment of severe brain injuries in military and civilian care.
University of California San Francisco
TemPredict: AI-Driven Wearable Monitoring for Early Illness Detection and Warfighter Readiness
TemPredict: AI wearables detect early illness and health risks to support warfighter readiness.