Sepsis Management

Sepsis management integrates early recognition, pathogen and host-response diagnostics, targeted antimicrobial and source-control therapies, and organ-support strategies. Military solutions must perform reliably in austere, prolonged-field-care and mass-casualty environments to prevent rapid deterioration and sustain operational readiness.

Technical Challenges

  • Heterogeneous host responses and variable clinical phenotypes complicate early, actionable diagnosis and triage.

  • Delayed evacuation and prolonged field care increase risk of progression to septic shock and multi-organ failure.

  • Rising antimicrobial resistance, biofilms, and polymicrobial wound infections undermine empiric therapy.

  • Limited availability of rapid, deployable diagnostics and continuous hemodynamic monitoring in austere settings.

Emerging Opportunities

  • Point-of-care pathogen ID with rapid phenotypic susceptibility for targeted therapy in the field.

  • Validated host-response biomarkers and prognostic tools to distinguish infection from inflammation and guide immunomodulation.

  • Rugged, low-power hemodynamic and organ-monitoring systems suitable for prolonged-field-care and evacuation delays.

  • Therapeutics and source-control technologies optimized for polytrauma, blast injuries, and contaminated wounds.

Current and Emerging Technologies in Sepsis Management

Rapid molecular and biosensor diagnostics

Isothermal PCR, CRISPR-based assays, and electrochemical biosensors for pathogen detection and toxin identification at point-of-care.

Host-response biomarkers & multi-omic profiling

Transcriptomic, proteomic, and metabolomic signatures and rapid biomarker panels to stratify sepsis phenotypes and guide immunomodulatory therapy.

Rapid phenotypic antimicrobial susceptibility

Microfluidic and culture-accelerating platforms that deliver susceptibility data within hours to enable targeted therapy and stewardship in forward settings.

Portable hemodynamic and microcirculation monitoring

Wearable sensors, miniaturized ultrasound, and noninvasive cardiac output/microvascular monitors for continuous assessment during evacuation and prolonged care.

Telemedicine, decision support & AI

Cloud-enabled clinical decision support, predictive analytics, and autonomous triage tools to augment medics and clinicians under resource constraints.

Adjunctive therapeutics and source-control innovations

Novel immunomodulators, bacteriophage and anti-toxin agents, negative-pressure and antimicrobial wound systems tailored for contaminated combat injuries.

Importance to Military Medicine

Combat casualty care and polytrauma

Sepsis complicates blast and penetrating wounds; rapid management reduces secondary organ injury and improves survival after polytrauma.

Prolonged and delayed evacuation

Solutions must sustain diagnostics and therapy when evacuation is delayed or care is extended at forward locations.

Austere and distributed care environments

Rugged, low-resource tools enable medics to identify and treat sepsis across dispersed operations and humanitarian missions.

Force readiness and public health protection

Preventing sepsis preserves mission capability, reduces medical evacuation burdens, and mitigates infectious-threat impacts on force health.

Alignment with the MTEC Mission

Accelerates translation of diagnostics and therapeutics from prototype to deployable solutions that meet DoD timelines and operational constraints.

Leverages multidisciplinary portfolios—infectious disease, trauma, telemedicine, and regenerative medicine—to address complex sepsis needs.

Prioritizes dual-use innovations that benefit both warfighters and civilian healthcare, aligning with MTEC’s translational mandate.

Enables rapid collaboration across academia, industry, and military medicine to validate and deploy scalable sepsis countermeasures.

Dual-Use (Military + Civilian) Applications

Improved hospital and emergency-room sepsis triage and early therapy through rapid POC diagnostics and prognostic biomarkers.

Enhanced public-health and biodefense preparedness via fast identification of pathogens and scalable treatment options during outbreaks.

Remote, rural, and low-resource healthcare settings benefit from rugged diagnostics, telemedicine augmentation, and portable monitoring.

Commercialization opportunities for rapid tests, AI decision tools, and novel therapeutics that bridge military and civilian markets.

Explore MTEC Members with Sepsis Management Capabilities

MTEC members bring deep domain expertise across infectious disease, trauma care, diagnostics, and systems engineering to deliver deployable sepsis solutions.

Members offer prototype platforms, clinical trial experience, regulatory strategy and manufacturing scale-up—enabling rapid transition from lab to field.

Explore member profiles to identify partners with biosensor, antimicrobial, wound-care, telehealth, and AI capabilities to accelerate sepsis innovation.

95 Members with Sepsis Management capabilities.

Member
Georgia Southern University

Georgia Southern University is a vibrant institution with over 26,100 students across three campuses in Statesboro, Savannah, and Hinesville. The university offers 132 degree programs at the associate, bachelor’s, master’s, and doctorate levels, emphasizing student success, community impact, and research excellence. With a commitment to inclusivity and engagement, Georgia Southern fosters a supportive environment for diverse learners, including military-affiliated and adult students. The university is dedicated to transforming lives through education and community engagement, aligning its programs with regional needs. Additionally, Georgia Southern provides accelerated pathways for students to fast-track their master's degrees, enhancing educational opportunities. The university also emphasizes career readiness and public impact research, preparing students for successful careers and contributing to community development.

Member
FiteBac Pharma

FiteBac Technology/FiteBac Pharma's K21 uniquely targets the underlying disease state, given that most diseases involve microbial-associated inflammation and mitochondrial dysfunction. FiteBac Technology innovations stem from the work of numerous international academic research scientists. FiteBac Pharma K21 is the blockbuster antimicrobial small molecule designed to modulate biological, immunological, and metabolic systems for treating a wide range of infectious and inflammatory diseases. This patented drug substance has demonstrated the ability to safely eliminate bacterial, fungal, and viral infections, enhance innate immunity, induce mitophagy while improving mitochondrial and cellular metabolism, accelerate wound healing, and even promote the development of zebrafish and chickens, leading to increased adult mass. Rigorous research from Dr. Bhupesh Prusty's laboratory and Dr Christopher Rongo's laboratory is focused on various aspects of mitochondrial remodeling and reprograming, as well as mitochondrial-to-nuclear signaling with K21.

Member
Qidni Labs

Qidni Labs is a NATO DIANA company recognized by Fast Company as a 2025 World Changing Idea. The company has developed a portable, nearly waterless hemodialysis system that will make treatment accessible for over 10 million patients every year.

Member
Armata Pharmaceuticals, Inc.

Armata Pharmaceuticals, Inc. is a clinical-stage biotechnology company dedicated to developing pathogen-specific bacteriophage therapeutics to combat antibiotic-resistant and difficult-to-treat bacterial infections. With a focus on addressing the global antibiotic resistance crisis, Armata leverages its proprietary bacteriophage-based technology to develop high-impact, best-in-class phage therapeutics. The company operates from a 56,000 square foot facility in Los Angeles, California, equipped for phage product development from bench to clinic. Armata's team of microbiologists and scientists work on discovering natural phages and enhancing them through synthetic biology and engineering to create tailored drug products for clinical trials.

Member
Auburn University

Auburn University Research & Economic Development is dedicated to advancing research and economic growth through a collaborative effort among its various colleges and departments. The organization focuses on fostering innovation, supporting faculty and student research, and facilitating partnerships with industry and government to address societal challenges and enhance the quality of life. Recent initiatives include the launch of the Team Science Series to promote interdisciplinary collaboration and the development of the Gulf Coast Engineering Research Station to address coastal environmental challenges.

Member
University of Arkansas

The Institute for Integrative & Innovative Research (I3R) at the University of Arkansas is dedicated to pioneering solutions to complex societal challenges through convergence research. With a mission to advance research excellence and stimulate economic development, I3R focuses on deploying innovations at scale through collaboration across various sectors, including academia, industry, and government.

Member
The University of Chicago

The University of Chicago is a prestigious urban research university committed to rigorous inquiry and intellectual freedom. Founded in 1890, it has produced numerous Nobel laureates and is known for its transformative education and groundbreaking research across various fields. The university fosters an inclusive and diverse learning environment, encouraging participation from all community members.

Member
Memsel

Memsel is a biotechnology research and development company dedicated to enhancing health and combatting infections through advanced phage therapies and targeted delivery systems. The company aims to transform healthcare solutions across human, animal, and plant domains, addressing critical health challenges and antibiotic resistance.

Member
Boston University

Boston University is a major research institution committed to leading breakthroughs across various disciplines. The Office of Research supports and advances research excellence, fostering collaboration among researchers, industry partners, and government leaders to address significant societal challenges.

Member
Baylor University

Baylor University is a preeminent Christian research university committed to addressing the world's most meaningful challenges through top-tier research and scholarship. Recognized as an R1 research institution, Baylor focuses on infusing its distinct Christian mission into its research initiatives, fostering a commitment to excellence and innovation.

Member
NEXT Labs, LLC

NEXT Labs is pioneering the automation and accessibility of next-generation sequencing (NGS) by developing affordable, portable solutions for sample and library preparation. Their mission is to enable sequencing anywhere, by anyone, moving NGS from specialized labs to point-of-need applications. By automating complex sample processing steps, NEXT Labs aims to democratize genomics research and diagnostics, making advanced testing faster, more accessible, and cost-effective for a wide range of applications including infectious disease detection, cancer, and neurodegenerative disease diagnostics.

Member
Kane Biotech

Kane Biotech is a Canadian-based biotechnology company focused on the research, development, and commercialization of products that prevent and remove microbial biofilms. Established in 2001, the company aims to improve human and animal welfare through innovative solutions to biofilm-related challenges and antimicrobial resistance. With a strong portfolio of 54 patents and patents pending, Kane Biotech is recognized as a leader in biofilm research and technology, and is listed on the TSX Venture Exchange under the symbol 'KNE' and on the OTC Markets under the symbol 'KNBIF'.

Member
Base Pair Biotechnologies

Base Pair Biotechnologies specializes in custom aptamer discovery and development for research, diagnostics, therapeutics, and industrial applications. The company leverages proprietary multiplex selection, advanced bioinformatics, and chemical modification techniques to develop high-affinity and selective nucleic acid aptamers. Base Pair enables affinity reagent development, biosensor design, and molecular detection for a broad range of targets and partners across academia and industry.

Member
Purgo Scientific

Purgo Scientific is a medical device company dedicated to developing effective solutions for the biofilm infections crisis in orthopedic surgery. Their mission is to provide a locally targeted sustained delivery device that ensures the right therapy is delivered to the right place for the right duration, ultimately improving patient outcomes and reducing the impact of surgical site infections.

Member
Nanovaccine Institute

The Nanovaccine Institute, established at Iowa State University in 2017, is a national transdisciplinary research consortium focused on advancing nano-based technologies to treat and prevent diseases. The institute aims to revolutionize public health outcomes through the design and promotion of nano-based vaccines and therapeutics.

Member
UVM An-Cockrell Lab Center for Biomedical Digital Twins

The UVM An-Cockrell Lab Center for Biomedical Digital Twins is a multidisciplinary research group leveraging advanced computational methods, including machine learning, agent-based modeling, and high-performance computing, to study complex biomedical and physiological phenomena. Their mission is to bridge the gap between basic science and clinical interventions by developing digital twins and computational models that inform precision medicine, therapeutic discovery, and translational research. The lab's work spans detailed organ and disease modeling, AI-driven clinical applications, and collaborative projects such as DARPA-funded initiatives, aiming to revolutionize healthcare through technology and simulation.

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Arizona State University

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University of Pittsburgh

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Theradaptive

Theradaptive’s RESTORE Trial Initiation for OsteoAdapt™ DE

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