Biophysics and Biomedical Modeling
Biophysics and biomedical modeling integrates biomechanics, cellular and tissue-scale physics, computational physiology, and machine learning to recreate injury mechanics, hemorrhage, infection dynamics, and host response. Models enable in silico trials, optimize sensor placement, predict decompensation, and support clinical decision-making in austere and prolonged-field-care settings.
Technical Challenges
Modeling heterogeneous polytrauma and blast biomechanics across scales from organ deformation to cellular injury.
Accurately predicting hemodynamic collapse and transfusion needs during delayed evacuation in austere settings.
Simulating host–pathogen interactions and biofilm dynamics for rapid antimicrobial decision support under antimicrobial resistance (AMR).
Integrating noisy, sparse physiological data from wearables and point-of-care devices into reliable real-time models.
Emerging Opportunities
Validated, deployable predictive models for hemorrhage control and resuscitation that work with limited inputs.
Standardized multiscale model validation pipelines tied to clinical outcomes and DoD priorities.
Computationally efficient digital twins usable on edge devices for prolonged field care and medics in forward areas.
Interoperable model-into-workflow tools connecting simulations with electronic health records, telemedicine, and battlefield decision aids.
Current and Emerging Technologies in Biophysics and Biomedical Modeling
Multiscale computational physiology
Couples cellular signaling, tissue mechanics, and organ-level hemodynamics to predict responses to trauma, resuscitation, and therapeutics. Enables virtual trials and sensitivity analyses for combat-relevant injuries.
Finite element and biomechanics modeling
High-fidelity simulations of blast, ballistic, and blunt-force trauma to inform protective equipment, surgical planning, and reconstructed anatomy for regenerative strategies.
Digital twins and patient-specific modeling
Personalized virtual patients drive scenario-based planning, anticipate clinical deterioration, and tailor interventions for prolonged casualty care or constrained evacuation timelines.
Machine learning–augmented mechanistic models
Hybrid approaches fuse physics-based models with data-driven methods to improve prediction from sparse battlefield sensors and to flag atypical trajectories such as occult hemorrhage or infection.
Rapid in silico trial platforms
Scalable simulation environments accelerate evaluation of devices, blood products, and therapeutics, reducing time to iterate prototypes relevant to DoD operational requirements.
Edge-capable real-time decision support
Lightweight algorithms and compressed models engineered for wearables, portable monitors, and handheld devices that provide medics with actionable predictions under connectivity constraints.
Importance to Military Medicine
Optimizes combat casualty care
Predictive models guide hemorrhage control, resuscitation strategies, and triage decisions where rapid clinical judgment can change survival.
Supports prolonged and austere care
Digital twins and edge models extend expertise into far‑forward environments, enabling medics to manage delayed evacuation and prolonged field care.
Improves readiness and medical planning
Simulations inform training, force health protection, and logistics for blood, antibiotics, and surgical capabilities under combat conditions.
Accelerates technology maturation
In silico evaluation shortens development cycles for devices and therapeutics prioritized by DoD, reducing time to deployment and civilian benefit.
Alignment with the MTEC Mission
Directly supports MTEC’s mission by accelerating transition of military-relevant medical technologies through validated modeling, simulation, and rapid iteration.
Aligns with DoD priorities—combat casualty care, force health protection, and prolonged care—by providing evidence-based decision tools and virtual testbeds.
Enables multidisciplinary consortia work across academia, industry, and military clinicians to validate models against operationally relevant datasets.
Supports dual-use outcomes by accelerating civilian translation of validated simulation tools for trauma care, infectious disease response, and surgical planning.
Dual-Use (Military + Civilian) Applications
Use cases include virtual testing of hemorrhage control devices, predicting sepsis trajectories for field triage, digital-twin surgical rehearsal, and optimized sensor networks for remote monitoring.
Explore MTEC Members with Biophysics and Biomedical Modeling Capabilities
MTEC members bring combined strengths in computational modeling, biomechanics, clinical trial design, regulatory strategy, and field validation. Industry accelerates engineering; academic partners provide model rigor and validation; military clinicians ensure operational relevance. Explore member profiles to identify collaborators with expertise in digital twins, in silico trials, edge analytics, and translational validation to advance military medical capability.
112 Members with Biophysics and Biomedical Modeling capabilities.
SIMETRI is a woman-and-minority owned small business based in Winter Park, Florida, specializing in modeling, simulation, and training technologies. Founded in 2009, the company focuses on delivering innovative products and services that enhance the human experience and improve client outcomes through advanced training and program management analysis.
IQVIA is a global leader in advanced analytics, technology solutions, and clinical research services for the life sciences industry. With a mission to accelerate innovation for a healthier world and a vision to power smarter healthcare for everyone, everywhere, IQVIA leverages unparalleled data, transformative technology, and deep healthcare expertise to drive better patient outcomes. Operating in over 100 countries with approximately 88,000 employees, IQVIA supports pharmaceutical, biotech, medtech, public health, and government organizations with a comprehensive portfolio of services and solutions. The company is recognized for its Connected Intelligence™, healthcare-grade AI, and commitment to sustainability, innovation, and evidence-based insights that shape the future of healthcare globally. IQVIA is also dedicated to reducing health inequities and driving sustainable change through innovation, collaboration, and data-driven solutions, partnering with organizations worldwide to address complex healthcare challenges.
Humanetics Corporation is a clinical-stage pharmaceutical company based in Minneapolis, Minnesota, focused on developing and commercializing products to enhance human health and wellbeing. Founded in 1988, the company specializes in radiation modulators, adjunctive oncology therapies, and pulmonary protective therapies, particularly for COVID-19. Humanetics is known for its lead drug candidate, BIO 300, which is being developed as a radioprotectant for military and civilian use, as well as a treatment to improve outcomes in cancer patients receiving radiotherapy. The company is actively engaged in research programs for non-small cell lung cancer, prostate cancer, and head and neck cancers.
Teleflex is a global provider of medical technologies designed to improve the health and quality of people's lives. The company focuses on purpose-driven innovation to empower healthcare professionals and enhance patient outcomes across various medical fields.
Aware Custom Biometric Wearables, is a leading innovator in cutting-edge in-ear technology, specializing in superior custom hearing protection solutions and biometric hearables. Our groundbreaking in-ear solutions feature enhanced hearing capabilities, continuous monitoring, and the collection of medical-grade biometric data, all designed to enhance human performance and safeguard lives. Our commitment to innovation is reflected in our meticulously crafted in-ear devices. Thanks to our patented 3D Ear Scanner technology, we provide a custom fit tailored to the unique shape of each individual's ear which optimizes the performance of sensors. Aware is transforming the ear into a dynamic platform for health and human performance by collecting medical-grade data, delivering actionable AI-driven insights, and enabling precision therapeutics within devices we wear in our everyday lives. Our technology serves a diverse range of sectors within healthcare, military, and industrial. Proudly U.S.-based, offices in Atlanta, GA and San Diego, CA. www.AwareCBW.com.
Seek Labs is a biotechnology company headquartered in Salt Lake City, Utah, dedicated to advancing scientific discovery and delivering universal healthcare solutions. The company specializes in next-generation point-of-care molecular diagnostics and programmable CRISPR-based therapeutics, aiming to bridge the gap between disease outbreak and intervention. Powered by its proprietary AI discovery engine, BioSeeker™, Seek Labs is building a modular, full-stack system that enables rapid response to emerging pathogens, scalable precision treatments, and accessible diagnostics. The company is committed to global health innovation, sustainability, and community engagement, and is a proud member of Utah's BioHive life sciences ecosystem. Seek Labs' mission is to empower individuals with healthcare solutions tailored to their specific needs, revolutionizing the detection and treatment of diseases for both human and animal health.
Sonogen Medical Inc. is dedicated to researching, developing, and commercializing next-generation ultrasonic bone fracture healing technology. The company combines expertise in fluid mechanics, biophysics, sonar, and medical ultrasound to create safe and effective devices for bone healing.
Vindhya Data Science is a women-owned small business headquartered in North Carolina, USA, with a presence in RTP and Boston. We specialize in bioinformatics, genomics, artificial intelligence, and data engineering, cheminformatics, evidence-based medicine, epidemiology and related disciplines. Vindhya partners with federal government agencies, leading academic medical centers, and pharma/biotech organizations to transform large datasets into informed decisions using advanced data science technologies. With over 100 years of combined experience, 150+ publications, and 73+ successful projects, Vindhya is committed to delivering impactful solutions in the life sciences sector.
The University of Chicago is a prestigious urban research university committed to rigorous inquiry and intellectual freedom. Founded in 1890, it has produced numerous Nobel laureates and is known for its transformative education and groundbreaking research across various fields. The university fosters an inclusive and diverse learning environment, encouraging participation from all community members.
JDSAT is a decision science company that fuses human insight with algorithmic precision to help organizations make faster, better-informed decisions, when the stakes are high, and the margin for error is low. We work across defense, interagency, and health sectors to build decision ecosystems that thrive in uncertainty. Whether you're leading transformation inside government or solving tough problems as a prime, JDSAT is your edge in complexity.
Booz Allen Hamilton is a leading management and technology consulting firm with over 110 years of experience. The company is dedicated to empowering people to change the world through innovative solutions in various sectors including cybersecurity, artificial intelligence, engineering, and defense. Booz Allen partners with government and commercial clients to tackle their most complex challenges, leveraging a culture of innovation and a commitment to excellence. The firm operates with core values of integrity, courage, service, ingenuity, and a commitment to diversity and inclusion.
PinMed, Inc., is a National Innovation Award-winning bioinformatics/medical-device company that develops high-fidelity cardiovascular monitoring systems, personalized (adaptive) software, and integrated systems and custom solutions for tracking cardiovascular data in the most challenging environments (e.g., intensive activity, extreme electromagnetic interference, and interventional cardiovascular procedures) and identifying subtle but clinically important indicators of cardiovascular events. PinMed’s award-winning solutions include versatile, multisensor, high-fidelity monitoring systems for various hospital and ambulatory settings. The company has extensive experience in electronic and mechanical engineering, development of software and firmware for various processors, computational modeling, and cardiovascular physiology. PinMed’s flagship mobile platform, PELEX, provides unparalleled versatility in physiological monitoring and has been cleared by the FDA for diagnostic 12-lead ECG testing and various types of ambulatory monitoring.
DLH delivers improved health and national security readiness solutions for federal programs through science research and development, systems engineering and integration, and digital transformation. With over 3,200 employees, DLH is committed to solving complex problems faced by civilian and military customers, leveraging advanced technologies and methodologies to enhance health outcomes and operational readiness.
Tietronix Software, Inc. is a minority-owned small business founded in 1999, located in Houston, Texas, near NASA Johnson Space Center. The company specializes in providing innovative software solutions and services across various sectors including medical, aerospace, and renewable energy. Tietronix is committed to high quality, reliability, and customer satisfaction, leveraging a diverse workforce and a strong project management team to deliver complex, mission-critical systems.
Altec is dedicated to advancing human potential by developing innovative human sensing technologies that enhance health science, operational security, and human performance. Founded in 1997 by Carlo De Luca, the company focuses on translating cutting-edge concepts into practical solutions that shape our understanding of human physiology. Altec's mission is to reimagine human potential through discovery, innovation, and collaboration, making significant strides in healthcare, security, and performance enhancement.
Exponent is a multidisciplinary science and engineering consulting firm serving sectors including healthcare, energy, manufacturing, and consumer products. From medical devices, pharmaceuticals, and supplements to digital health and wearables, we deliver rigorous science that quantifies impacts on human health. Exponent helps you push the envelope on the development, deployment, safety, and effectiveness of cutting-edge drugs, devices, and diagnostics — concomitantly balancing benefits and risks. Count on our multidisciplinary, data-driven, evidence-based assessments to give you clarity on your most complex product needs and challenges. With lives on the line, innovations that support healthcare demand the highest levels of scientific rigor. Whether you’re developing a novel drug, a sturdier stent, or a faster flu test, you need clear answers to complex questions, quickly. Exponent supports our life sciences clients across the total product lifecycle by solving critical design, regulatory, safety, and market access challenges. We can collaborate with you throughout your journey, helping you navigate risks and opportunities — and optimize outcomes — with science-based strategies and specialized expertise.

University of California San Francisco
TemPredict: AI-Driven Wearable Monitoring for Early Illness Detection and Warfighter Readiness
TemPredict: AI wearables detect early illness and health risks to support warfighter readiness.
Arizona State University
ASU Crosscutting Technologies to Enhance Military Medical Readiness and Resilience
Dr. Rachel Cassalia leads MTEC-supported efforts at ASU to shift military health from reactive care to proactive readiness through data-driven prevention.
University of Pittsburgh
Topical Metformin Lotion for Tendinopathy Prevention
University of Pittsburgh study shows topical metformin prevents overuse tendon injury. This work was sponsored through MTEC project 22-02-MPAI-014.
Theradaptive
Theradaptive’s RESTORE Trial Initiation for OsteoAdapt™ DE
Theradaptive launches RESTORE Phase I/II trial of OsteoAdapt™ DE for faster, precision bone healing in craniofacial injuries. MTEC-funded study targets improved recovery for military and civilian patients.