Synvolux
Manufacturer and developer of non-viral, synthetic lipid-based delivery reagents for intracellular delivery of DNA, RNA and proteins. Offers a portfolio of serum‑compatible transfection reagents for in vitro and in vivo use, custom formulation and optimization services, and GMP-capable production for clinical studies. Located in Leiden Bio Science Park, the Netherlands.
Industries
Nr. of Employees
small (1-50)
Synvolux
Leiden, Zuid-Holland, The Netherlands, Europe
Products
DNA transfection reagent (lipid-based)
PBS-compatible lipid formulation for in vitro DNA transfection; reported high efficiencies in many cell lines and suitability for rollerbottle transfection.
Small RNA transfection reagent (siRNA/miRNA)
RNase-free lipid formulation for efficient delivery of small RNAs; suitable for high-throughput screening and serum-compatible protocols including an alternative serum-free protocol for sensitive cases.
mRNA transfection reagent (lipid-based)
Lipid formulation optimized for mRNA delivery that enables rapid transient protein expression with reported efficiencies between ~90–100% in standard cell lines under optimized conditions.
Protein and peptide transfection reagent
Fully synthetic lipid reagent that non-covalently complexes with proteins and peptides for cellular delivery; reported high uptake efficiencies and compatibility with PBS and serum.
In vivo transfection reagent (formulation for animal/clinical use)
Optimized cationic lipid formulations for in vivo gene delivery and DNA vaccination demonstrated in multiple animal models; offered in GMP-capable formats for preclinical and clinical studies.
Targeted liposomal formulations for targeted delivery
Custom antibody- or ligand-directed liposomes for selective delivery of nucleic acids (e.g., siRNA) to specific cell types, demonstrated in endothelial targeting examples.
DNA transfection reagent (lipid-based)
PBS-compatible lipid formulation for in vitro DNA transfection; reported high efficiencies in many cell lines and suitability for rollerbottle transfection.
Small RNA transfection reagent (siRNA/miRNA)
RNase-free lipid formulation for efficient delivery of small RNAs; suitable for high-throughput screening and serum-compatible protocols including an alternative serum-free protocol for sensitive cases.
mRNA transfection reagent (lipid-based)
Lipid formulation optimized for mRNA delivery that enables rapid transient protein expression with reported efficiencies between ~90–100% in standard cell lines under optimized conditions.
Protein and peptide transfection reagent
Fully synthetic lipid reagent that non-covalently complexes with proteins and peptides for cellular delivery; reported high uptake efficiencies and compatibility with PBS and serum.
In vivo transfection reagent (formulation for animal/clinical use)
Optimized cationic lipid formulations for in vivo gene delivery and DNA vaccination demonstrated in multiple animal models; offered in GMP-capable formats for preclinical and clinical studies.
Targeted liposomal formulations for targeted delivery
Custom antibody- or ligand-directed liposomes for selective delivery of nucleic acids (e.g., siRNA) to specific cell types, demonstrated in endothelial targeting examples.
Services
Custom formulation development
Design and manufacture of bespoke liposomal formulations and custom volumes for specific research or preclinical applications.
Screening and optimization services
Custom screening of formulation variants and optimization for difficult-to-transfect cells or high-throughput formats.
GMP-capable production and clinical supply support
Production processes and specifications designed to enable GMP-grade reagent manufacture for clinical studies, including heat-sterilizable formulations.
Licensing and collaboration
Opportunities for licensing of technology, co-development, and research collaborations including participation in funding programmes and grant applications.
Custom formulation development
Design and manufacture of bespoke liposomal formulations and custom volumes for specific research or preclinical applications.
Screening and optimization services
Custom screening of formulation variants and optimization for difficult-to-transfect cells or high-throughput formats.
GMP-capable production and clinical supply support
Production processes and specifications designed to enable GMP-grade reagent manufacture for clinical studies, including heat-sterilizable formulations.
Licensing and collaboration
Opportunities for licensing of technology, co-development, and research collaborations including participation in funding programmes and grant applications.
Expertise Areas
- Non-viral lipid-based delivery
- Transfection reagent development and optimization
- GMP-capable manufacturing for clinical supply
- Targeted liposomal delivery
Key Technologies
- Synthetic cationic lipid formulations
- Liposomal targeted delivery (antibody/ligand-directed)
- Lyophilized lipid raw materials
- Heat-sterilizable lipid formulations