Synvolux
Manufacturer and developer of non-viral, synthetic lipid-based delivery reagents for intracellular delivery of DNA, RNA and proteins. Offers a portfolio of serum‑compatible transfection reagents for in vitro and in vivo use, custom formulation and optimization services, and GMP-capable production for clinical studies. Located in Leiden Bio Science Park, the Netherlands.
Industries
Nr. of Employees
small (1-50)
Synvolux
J.H. Oortweg 19-21, 2333 CH Leiden, The Netherlands
Products
DNA transfection reagent (lipid-based)
PBS-compatible lipid formulation for in vitro DNA transfection; reported high efficiencies in many cell lines and suitability for rollerbottle transfection.
Small RNA transfection reagent (siRNA/miRNA)
RNase-free lipid formulation for efficient delivery of small RNAs; suitable for high-throughput screening and serum-compatible protocols including an alternative serum-free protocol for sensitive cases.
mRNA transfection reagent (lipid-based)
Lipid formulation optimized for mRNA delivery that enables rapid transient protein expression with reported efficiencies between ~90–100% in standard cell lines under optimized conditions.
Protein and peptide transfection reagent
Fully synthetic lipid reagent that non-covalently complexes with proteins and peptides for cellular delivery; reported high uptake efficiencies and compatibility with PBS and serum.
In vivo transfection reagent (formulation for animal/clinical use)
Optimized cationic lipid formulations for in vivo gene delivery and DNA vaccination demonstrated in multiple animal models; offered in GMP-capable formats for preclinical and clinical studies.
Targeted liposomal formulations for targeted delivery
Custom antibody- or ligand-directed liposomes for selective delivery of nucleic acids (e.g., siRNA) to specific cell types, demonstrated in endothelial targeting examples.
DNA transfection reagent (lipid-based)
PBS-compatible lipid formulation for in vitro DNA transfection; reported high efficiencies in many cell lines and suitability for rollerbottle transfection.
Small RNA transfection reagent (siRNA/miRNA)
RNase-free lipid formulation for efficient delivery of small RNAs; suitable for high-throughput screening and serum-compatible protocols including an alternative serum-free protocol for sensitive cases.
mRNA transfection reagent (lipid-based)
Lipid formulation optimized for mRNA delivery that enables rapid transient protein expression with reported efficiencies between ~90–100% in standard cell lines under optimized conditions.
Protein and peptide transfection reagent
Fully synthetic lipid reagent that non-covalently complexes with proteins and peptides for cellular delivery; reported high uptake efficiencies and compatibility with PBS and serum.
In vivo transfection reagent (formulation for animal/clinical use)
Optimized cationic lipid formulations for in vivo gene delivery and DNA vaccination demonstrated in multiple animal models; offered in GMP-capable formats for preclinical and clinical studies.
Targeted liposomal formulations for targeted delivery
Custom antibody- or ligand-directed liposomes for selective delivery of nucleic acids (e.g., siRNA) to specific cell types, demonstrated in endothelial targeting examples.
Services
Design and manufacture of bespoke liposomal formulations and custom volumes for specific research or preclinical applications.
Custom screening of formulation variants and optimization for difficult-to-transfect cells or high-throughput formats.
Production processes and specifications designed to enable GMP-grade reagent manufacture for clinical studies, including heat-sterilizable formulations.
Opportunities for licensing of technology, co-development, and research collaborations including participation in funding programmes and grant applications.
Design and manufacture of bespoke liposomal formulations and custom volumes for specific research or preclinical applications.
Custom screening of formulation variants and optimization for difficult-to-transfect cells or high-throughput formats.
Production processes and specifications designed to enable GMP-grade reagent manufacture for clinical studies, including heat-sterilizable formulations.
Opportunities for licensing of technology, co-development, and research collaborations including participation in funding programmes and grant applications.
Expertise Areas
- Non-viral lipid-based delivery
- Transfection reagent development and optimization
- GMP-capable manufacturing for clinical supply
- Targeted liposomal delivery
Key Technologies
- Synthetic cationic lipid formulations
- Liposomal targeted delivery (antibody/ligand-directed)
- Lyophilized lipid raw materials
- Heat-sterilizable lipid formulations
News & Updates
Company moved offices and facilities to Leiden in January 2016; facilities include labs for molecular biology, immunology/cell culture, organic chemistry, vector production, manufacturing and storage.
Description of animal studies and references demonstrating in vivo delivery and DNA vaccination applications using the company's lipid formulations; mentions use of GMP-grade lipids in a clinical study at a medical center.
Maintains more than 20 issued patents and patent applications and a proprietary formulation library of numerous lipid formulations for optimized transfection.
GMP-grade, heat-sterilizable lipid reagents are stated to be in use in a clinical study (reference to an identified clinical trial in provided content).
Company moved offices and facilities to Leiden in January 2016; facilities include labs for molecular biology, immunology/cell culture, organic chemistry, vector production, manufacturing and storage.
Description of animal studies and references demonstrating in vivo delivery and DNA vaccination applications using the company's lipid formulations; mentions use of GMP-grade lipids in a clinical study at a medical center.
Maintains more than 20 issued patents and patent applications and a proprietary formulation library of numerous lipid formulations for optimized transfection.
GMP-grade, heat-sterilizable lipid reagents are stated to be in use in a clinical study (reference to an identified clinical trial in provided content).