Northern RNA, Inc.
Northern RNA is a leading Contract Development and Manufacturing Organization (CDMO) specializing in the manufacturing and production of nucleic acid products used in applications including mRNA vaccines, DNA vaccines, mRNA therapies, gene editing, and gene therapies. Founded in 2020, the company aims to provide secure, clinical-to-commercial scale, GMP-grade manufacturing for global clients, supporting innovative therapies and advancing Canada's biomanufacturing sector.
Industries
Nr. of Employees
small (1-50)
Northern RNA, Inc.
Products
Codon- and UTR-optimized linear plasmid DNA (ready-to-order)
RNase-free, codon- and UTR-optimized linear plasmid DNA produced using proprietary purification methods with endotoxin clearance; available in research, RSM, and GMP grades for preclinical and clinical use.
Capped and modified mRNA (ready-to-order)
High-quality capped and modified mRNA produced with methods to reduce double-stranded RNA and other impurities; available in research and GMP grades and suitable for R&D, GLP, and clinical studies.
Co-transcriptional cap analog reagent
Co-transcriptional cap analog reagents for use during in vitro transcription to generate capped mRNA with improved translational efficiency and protection from exonuclease degradation; available in multiple pack sizes and in research or GMP grades.
Codon- and UTR-optimized linear plasmid DNA (ready-to-order)
RNase-free, codon- and UTR-optimized linear plasmid DNA produced using proprietary purification methods with endotoxin clearance; available in research, RSM, and GMP grades for preclinical and clinical use.
Capped and modified mRNA (ready-to-order)
High-quality capped and modified mRNA produced with methods to reduce double-stranded RNA and other impurities; available in research and GMP grades and suitable for R&D, GLP, and clinical studies.
Co-transcriptional cap analog reagent
Co-transcriptional cap analog reagents for use during in vitro transcription to generate capped mRNA with improved translational efficiency and protection from exonuclease degradation; available in multiple pack sizes and in research or GMP grades.
Services
Biomanufacturing
Platform-scale biomanufacturing services for research and GMP applications including process scale-up, documentation support, and QA oversight.
Plasmid DNA Production
Production of research, RSM, and GMP-grade linear and supercoiled plasmid DNA with support for complex constructs and fill/finish options.
mRNA Production
Manufacture of research, RSM, and GMP-grade mRNA (short and long constructs) with double-stranded RNA clearance, documentation, and QA processes for clinical readiness.
Microbial Cell Banking
Creation of parental, research, master, and working cell banks under ISO-classified conditions with validated release assays and QA oversight.
Formulation and LNP Services
End-to-end formulation development and manufacturing support for LNP-encapsulated nucleic acids, including characterization, process transfer, and clinical-scale production readiness.
Chemical Manufacturing
Chemical synthesis and purification for cap analogs, lipids, and custom reagents with kg-scale production capability and proprietary purification methods.
Biomanufacturing
Platform-scale biomanufacturing services for research and GMP applications including process scale-up, documentation support, and QA oversight.
Plasmid DNA Production
Production of research, RSM, and GMP-grade linear and supercoiled plasmid DNA with support for complex constructs and fill/finish options.
mRNA Production
Manufacture of research, RSM, and GMP-grade mRNA (short and long constructs) with double-stranded RNA clearance, documentation, and QA processes for clinical readiness.
Microbial Cell Banking
Creation of parental, research, master, and working cell banks under ISO-classified conditions with validated release assays and QA oversight.
Formulation and LNP Services
End-to-end formulation development and manufacturing support for LNP-encapsulated nucleic acids, including characterization, process transfer, and clinical-scale production readiness.
Chemical Manufacturing
Chemical synthesis and purification for cap analogs, lipids, and custom reagents with kg-scale production capability and proprietary purification methods.
Expertise Areas
- mRNA drug substance and drug product manufacturing
- Plasmid DNA production and construct optimization
- LNP formulation and lipid manufacturing
- Chemical synthesis for biologics reagents (cap analogs, lipids, oligonucleotides)
Key Technologies
- Lipid nanoparticle (LNP) formulation
- Microfluidic rapid mixing
- Tangential flow filtration (TFF)
- Lyophilization