Protein Metrics


Protein Metrics is a provider of vendor-neutral mass spectrometry software for comprehensive protein and oligo analysis across the development process. Their mission is to facilitate biotherapeutic analysis from research through industrial production, offering software with unique algorithms to minimize ambiguity, achieve reproducibility, and eliminate lab-to-lab variability. As part of Dotmatics, they leverage a collaborative environment with a focus on integrating data seamlessly to support better decision-making and accelerate biologics development.

Industries

Software
Biotechnology
Data Mining
Analytics
Biotechnology Research

Nr. of Employees

medium (51-250)

Protein Metrics

Boston, Massachusetts, United States


Patents

Pseudo-electropherogram construction from peptide level mass spectrometry data

US-12352757-B2

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Data compression for multidimensional time series data

US-12205331-B2

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Pseudo-electropherogram construction from peptide level mass spectrometry data

US-12038444-B2

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Apparatuses and methods for digital pathology

US-11908130-B2

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Data compression for multidimensional time series data

US-11790559-B2

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Interactive analysis of mass spectrometry data including peak selection and dynamic labeling

US-11626274-B2

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Products

Byos

Desktop software offering automated workflows for biotherapeutic characterization including peptide, intact, chromatogram, glycan and oligonucleotide analyses.

Byonic (MS/MS search engine)

MS/MS search engine for sensitive peptide and glycopeptide identification, enabling wildcard and complex modification searches.

Byosphere (enterprise platform)

Cloud or server-based platform that centralizes mass spec data, enables deep-query analytics, dashboards, and collaborative reporting for multi-site labs.

Byonic Viewer

Free viewer application for interactive exploration of MS/MS search results generated by the MS/MS search engine.

Proteome Discoverer integration nodes

Node plugins that integrate search and preview capabilities into third-party data-processing suites to run searches inside those environments.

Protein Metrics product suite (PMI Suite)

Bundled installer containing desktop analysis software and associated workflows for peptide, intact, chromatogram, de novo, glycan, and oligonucleotide analyses.


Services

Cloud-hosted platform for centralizing MS data, running shared workflows, creating dashboards, and enabling cross-site collaboration and deep-query analytics.

Desktop client that connects to application servers for job submission, file transfer, result inspection and report viewing to integrate local analysis with enterprise systems.

Provision of curated training datasets and validation packages intended to support software validation, user training, and analytical method qualification.

Customer support resources, FAQs, and access to application scientists for assistance with analytical workflows and software use.

Personal demonstrations and time-limited trials of the software suite for evaluation and testing in user workflows.

Expertise Areas

  • Proteomics data analysis
  • Biotherapeutic protein characterization
  • Mass spectrometry data processing
  • Oligonucleotide and mRNA analytical workflows
  • Show More (6)

Key Technologies

  • Liquid chromatography–mass spectrometry (LC‑MS, LC‑MS/MS)
  • Native and intact mass deconvolution
  • MS/MS search engines
  • De novo sequencing algorithms
  • Show More (8)

News & Updates

Oligo analysis got you in knots? Get clear, confident results. Master LC-MS characterisation, isomer resolution, and automated reporting.

Streamline glycoprotein QC: discover automated MS glycan grouping for faster, clearer biotherapeutic insight in development today

Discover how Byos enables sensitive, label-free HCP quantitation across CHO downstream steps—fast, scalable, and reproducible.

Automated workflows for analyzing antibody-drug conjugates, from fractionation and digestion to high-sensitivity nanoflow LC-MS/MS.

Comprehensive mRNA Characterization: Sequence, Cap Structures, and PolyA Tails in One Workflow

Discover how LCMS QTOF and Byos streamline monoclonal antibody characterization, delivering high-resolution insights, automated workflows, and enhanced data analysis.

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