MtoZ-Biolabs
MtoZ Biolabs is an integrated contract research organization (CRO) specializing in proteomics, metabolomics, bioinformatics, biopharmaceutical analysis services, and advanced structural analysis. They utilize cutting-edge mass spectrometry and chromatography platforms to provide rapid, high-throughput, and cost-effective research solutions in biochemistry, biotechnology, and biopharmaceutical fields, supporting scientific discovery, development, and structural characterization.
Industries
Nr. of Employees
small (1-50)
Products
Protein Sequencing
Provides complete sequencing of proteins, including N-terminal, C-terminal, and full-length sequencing using various methods like Edman degradation and LC-MS/MS.
Quantitative Proteomics
Offers quantitative analysis of proteins using techniques such as label-free, TMT/iTRAQ, SILAC/Dimethyl, MRM, and SWATH.
Targeted Metabolomics
Analyzes specific metabolites within a sample using targeted approaches to identify and quantify metabolites.
Untargeted Metabolomics
Performs comprehensive analysis to identify and quantify all metabolites in a sample without prior knowledge of the metabolites.
Lipidomics
Analyzes lipids and their interactions within biological samples to understand lipid metabolism and its role in biological processes.
Post-translational Modification (PTM) Analysis
Identifies and quantifies post-translational modifications such as phosphorylation, acetylation, ubiquitination, glycosylation, and disulfide bonds.
Protein Sequencing
Provides complete sequencing of proteins, including N-terminal, C-terminal, and full-length sequencing using various methods like Edman degradation and LC-MS/MS.
Quantitative Proteomics
Offers quantitative analysis of proteins using techniques such as label-free, TMT/iTRAQ, SILAC/Dimethyl, MRM, and SWATH.
Targeted Metabolomics
Analyzes specific metabolites within a sample using targeted approaches to identify and quantify metabolites.
Untargeted Metabolomics
Performs comprehensive analysis to identify and quantify all metabolites in a sample without prior knowledge of the metabolites.
Lipidomics
Analyzes lipids and their interactions within biological samples to understand lipid metabolism and its role in biological processes.
Post-translational Modification (PTM) Analysis
Identifies and quantifies post-translational modifications such as phosphorylation, acetylation, ubiquitination, glycosylation, and disulfide bonds.
Services
Ion-mobility-enhanced proteomics integrating ion mobility with LC–MS/MS to improve sensitivity, separate isomeric peptides and support low-input and high-throughput cohort studies. Deliverables include experimental procedures, instrument parameters, raw data and analysis reports.
Targeted absolute quantification using stable isotope-labeled synthetic peptides and SRM/MRM workflows to measure absolute protein and PTM levels from digested samples with quantitative reporting and raw data.
Single-cell immune-repertoire profiling including sample preparation, barcoded library construction, high-throughput sequencing and computational analysis to resolve T cell clonotypes at single-cell resolution.
Single-cell B cell receptor sequencing including cell enrichment, barcoded library preparation, high-throughput sequencing and bioinformatic analysis to profile BCR diversity and clonal evolution.
Workflows for protein digestion (including multiple proteases), peptide cleanup, LC separation, MS/MS identification and quantitative comparison (isobaric or label-free) with bioinformatic peptide-to-protein mapping and PTM detection.
Phosphoproteomics workflows combining enrichment, mass spectrometric identification and quantitative profiling to map signaling pathway changes and discover phosphorylation biomarkers.
Ion-mobility-enhanced proteomics integrating ion mobility with LC–MS/MS to improve sensitivity, separate isomeric peptides and support low-input and high-throughput cohort studies. Deliverables include experimental procedures, instrument parameters, raw data and analysis reports.
Targeted absolute quantification using stable isotope-labeled synthetic peptides and SRM/MRM workflows to measure absolute protein and PTM levels from digested samples with quantitative reporting and raw data.
Single-cell immune-repertoire profiling including sample preparation, barcoded library construction, high-throughput sequencing and computational analysis to resolve T cell clonotypes at single-cell resolution.
Single-cell B cell receptor sequencing including cell enrichment, barcoded library preparation, high-throughput sequencing and bioinformatic analysis to profile BCR diversity and clonal evolution.
Workflows for protein digestion (including multiple proteases), peptide cleanup, LC separation, MS/MS identification and quantitative comparison (isobaric or label-free) with bioinformatic peptide-to-protein mapping and PTM detection.
Phosphoproteomics workflows combining enrichment, mass spectrometric identification and quantitative profiling to map signaling pathway changes and discover phosphorylation biomarkers.
Expertise Areas
- Mass spectrometry-based proteomics
- Ion-mobility and high-throughput proteomics
- Targeted and quantitative proteomics assay development
- Post-translational modification (PTM) analysis and enrichment
Key Technologies
- Liquid chromatography–tandem mass spectrometry (LC–MS/MS)
- MALDI‑TOF mass spectrometry
- Ion mobility separation with serial fragmentation
- High-resolution Orbitrap-class mass spectrometry