Nature's Toolbox, Inc.
NTx Bio is redefining biomanufacturing with an automated platform that enables scalable, high-quality RNA and protein production on demand. Their proprietary platforms, including NTxscribe® and NTxpress®, facilitate rapid, scalable, and accessible biomanufacturing solutions for next-generation therapeutics, accelerating the path from discovery to impact and making advanced therapies more accessible worldwide.
Industries
Nr. of Employees
small (1-50)
Nature's Toolbox, Inc.
Patents
Non-hierarchical infrastructure for managing twin-security keys of physical persons or of elements (IGCP/PKI)
US-9397839-B2
View Details
Non-hierarchical infrastructure for managing twin-security keys of physical persons or of elements (IGCP/PKI)
US-9397839-B2
View DetailsProducts
Benchtop continuous-flow RNA IVT and purification system
Compact automated system implementing continuous-flow IVT in hollow-fiber reactors with co-transcriptional capping and inline purification. Designed to produce high-integrity mRNA/saRNA on a benchtop footprint with linear scalability from mg to gram scale and rapid cycle times (reported ~10–65+ mg output in ~3 hours). Single-use closed-system options and integration points for in-line analytics.
Fully recombinant cell-free protein synthesis platform
Recombinant, thermostable cell-free transcription/translation platform engineered to produce high-yield, high-purity proteins without crude cell extracts, including an ATP regeneration system and compatibility with linear and circular DNA templates.
Benchtop continuous-flow RNA IVT and purification system
Compact automated system implementing continuous-flow IVT in hollow-fiber reactors with co-transcriptional capping and inline purification. Designed to produce high-integrity mRNA/saRNA on a benchtop footprint with linear scalability from mg to gram scale and rapid cycle times (reported ~10–65+ mg output in ~3 hours). Single-use closed-system options and integration points for in-line analytics.
Fully recombinant cell-free protein synthesis platform
Recombinant, thermostable cell-free transcription/translation platform engineered to produce high-yield, high-purity proteins without crude cell extracts, including an ATP regeneration system and compatibility with linear and circular DNA templates.
Services
On-demand mRNA production using a continuous-flow IVT and purification platform. Standard turnaround ~2 weeks for non-complex sequences. Standard package sizes offered (e.g., 5 mg, 10 mg, 25 mg). Options for modified nucleotides, formulation, and expanded QC panels.
Commercial on-demand RNA manufacturing leveraging continuous-flow benchtop systems to deliver purified mRNA constructs at defined quantities and rapid timelines.
Planned cryo-electron microscopy services to complement molecular and structural characterization workflows.
On-demand mRNA production using a continuous-flow IVT and purification platform. Standard turnaround ~2 weeks for non-complex sequences. Standard package sizes offered (e.g., 5 mg, 10 mg, 25 mg). Options for modified nucleotides, formulation, and expanded QC panels.
Commercial on-demand RNA manufacturing leveraging continuous-flow benchtop systems to deliver purified mRNA constructs at defined quantities and rapid timelines.
Planned cryo-electron microscopy services to complement molecular and structural characterization workflows.
Expertise Areas
- Cell-free biomanufacturing
- mRNA and self-amplifying RNA production
- Cell-free protein expression
- Continuous-flow bioprocessing and hollow-fiber reactors
Key Technologies
- Hollow-fiber continuous-flow bioreactors
- Co-transcriptional 5' capping
- Tangential flow filtration (TFF) purification
- Fully recombinant cell-free transcription/translation
News & Updates
May 15, 2025 11:21:42 AM - Governor Greg Abbott announced that NTxBio will establish a biomanufacturing facility.
Mar 13, 2025 7:00:00 AM - The inaugural group of experts from Yale Cancer Center, Mayo Clinic, MD Anderson Cancer Center, Dana Farber, and others.
Mar 4, 2025 8:00:20 AM - Joan Haab brings decades of experience at biotech and diagnostics companies.
Jan 9, 2025 8:05:40 AM - NTxscribe benchtop system produces high integrity RNA in three hours.
Dec 4, 2024 7:00:00 AM - The financing supports the adoption of NTx distributed biomanufacturing systems.
Oct 31, 2024 10:22:14 AM - Get a first look at NTxscribe®, a continuous flow mRNA in vitro transcription and purification system.
May 15, 2025 11:21:42 AM - Governor Greg Abbott announced that NTxBio will establish a biomanufacturing facility.
Mar 13, 2025 7:00:00 AM - The inaugural group of experts from Yale Cancer Center, Mayo Clinic, MD Anderson Cancer Center, Dana Farber, and others.
Mar 4, 2025 8:00:20 AM - Joan Haab brings decades of experience at biotech and diagnostics companies.
Jan 9, 2025 8:05:40 AM - NTxscribe benchtop system produces high integrity RNA in three hours.
Dec 4, 2024 7:00:00 AM - The financing supports the adoption of NTx distributed biomanufacturing systems.
Oct 31, 2024 10:22:14 AM - Get a first look at NTxscribe®, a continuous flow mRNA in vitro transcription and purification system.