Nuclera


Nuclera develops automated benchtop platforms and integrated systems for rapid protein expression, optimization, and purification, utilizing cell-free synthesis, digital microfluidics, and software-driven workflows. Their technology enables miniaturized and scalable protein prototyping—including challenging targets such as membrane proteins—directly at the lab bench. Nuclera serves academic and industrial researchers, focusing on reducing turnaround time for functional protein access and streamlining screening and production. The company has secured significant funding to enable broad commercialization, expanded their leadership team to support scale-up, and continues to drive advancements in drug discovery, proteomics, and experimental automation.

Nuclera

Nuclera

1000 Technology Park Dr, Suite B, Billerica, MA 01821


Patents

Method of oligonucleotide synthesis

2025-10-14 • US-12442028-B2

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Microfluidic devices containing reversibly pinned droplet samples and methods

2025-07-29 • US-12370550-B2

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Modified terminal deoxynucleotidyl transferase (TdT) enzymes

2025-05-27 • US-12312611-B2

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Method for reagent-specific driving EWoD arrays in microfluidic systems

2024-12-31 • US-12179203-B2

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Polymer synthesis using electrowetting devices

2024-10-29 • US-12129501-B2

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Dielectric layers for digital microfluidic devices

2024-10-29 • US-12128411-B2

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What We Do

Integrated benchtop system for cell-free protein synthesis, digital microfluidics, and software-driven automation to accelerate the design, screening, and purification of proteins, including membrane proteins.

Provision of rapid, high-throughput protein expression and purification services through contract research organizations utilizing automated benchtop systems.


Diagnostics


Key People

Chief Executive Officer and Co-founder

Chairman of the Board

Chief Financial Officer

Chief Commercial Officer

VP of Intellectual Property

LinkedIn

Associate Vice President, Marketing


News & Updates

Received Innovate UK grants supporting advanced platform development, including for fast protein prototyping and engineering biology.

Ranked among the fastest-growing startups in the UK and Ireland for 2024.

Certified for cybersecurity practices by the UK government standard.

Recognized as one of the UK's most exciting growth-stage technology companies by Tech Nation.

Created new headquarters at One Vision Park to support operational growth and the commercial launch of protein prototyping technology.

Secured $75 million to accelerate commercial rollout of benchtop protein screening and production technology.

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