Clarus Analytical
Provider of mass spectrometry–based analytical services for academic and pharma/biotech clients. Focus areas include targeted and untargeted metabolomics, quantitative LC-MS/MS assay development and validation for preclinical and clinical studies, 13C metabolic flux analysis, PK/PD bioanalysis and modeling, statistical/metabolomics data analysis, and laboratory method transfer and consulting.
Industries
Nr. of Employees
small (1-50)
Clarus Analytical
San Diego, California, United States, North America
Products
Intracellular energy metabolite panel
Quantitative panel measuring primary intracellular energy metabolites and cofactors (nucleotides, sugar phosphates, coenzymes/cofactors, acyl-CoAs) from cell culture or tissue matrices; includes stable isotope standards.
Lipidomics panel
Relative quantification panel for phospholipids, fatty acids, eicosanoids, acylcarnitines, and bile acids optimized for plasma and serum and adaptable to other tissues.
Global metabolite panel
Broad panel covering several hundred metabolites (amino acids, organic acids, acylcarnitines, purines/pyrimidines, bile acids, etc.) using separate runs and multiple ionization modes for diverse biofluids and tissues.
Custom LC-MS/MS Assays
Custom LC-MS/MS assays developed and validated for precision and accuracy using QC analysis and calibration curves for your analytes of interest.
Custom LC-MS Assays
Custom mass spectrometry based quantitative assays for measuring metabolites, peptides, and drug compounds.
Metabolomics and Lipidomics Services
Targeted quantitative metabolomics and lipidomics of hundreds of metabolites from various metabolic pathways, and untargeted metabolomics profiling for biomarker discovery.
Intracellular energy metabolite panel
Quantitative panel measuring primary intracellular energy metabolites and cofactors (nucleotides, sugar phosphates, coenzymes/cofactors, acyl-CoAs) from cell culture or tissue matrices; includes stable isotope standards.
Lipidomics panel
Relative quantification panel for phospholipids, fatty acids, eicosanoids, acylcarnitines, and bile acids optimized for plasma and serum and adaptable to other tissues.
Global metabolite panel
Broad panel covering several hundred metabolites (amino acids, organic acids, acylcarnitines, purines/pyrimidines, bile acids, etc.) using separate runs and multiple ionization modes for diverse biofluids and tissues.
Custom LC-MS/MS Assays
Custom LC-MS/MS assays developed and validated for precision and accuracy using QC analysis and calibration curves for your analytes of interest.
Custom LC-MS Assays
Custom mass spectrometry based quantitative assays for measuring metabolites, peptides, and drug compounds.
Metabolomics and Lipidomics Services
Targeted quantitative metabolomics and lipidomics of hundreds of metabolites from various metabolic pathways, and untargeted metabolomics profiling for biomarker discovery.
Services
Develop and optimize LC-MS/MS methods for quantification of metabolites, peptides, and drugs; evaluate matrices, recovery, stability, and interferences; deliver methods for in-house use or transfer to client platforms.
Guidance and execution of bioanalytical validation steps to meet rigorous criteria including QC/QA management, selection of matrices and internal standards, recovery/accuracy/precision testing, and SOP development.
Quantitative panels for intracellular energy metabolites, lipid classes, and a global metabolite panel with absolute or relative quantification using stable-isotope internal standards and multi-point calibration.
High-resolution untargeted profiling to identify differential analytes and candidate biomarkers, followed by identification through database matching, comparison to standards, or ultra-high-resolution analysis.
Design and measurement of 13C tracer incorporation and isotopologue distributions for glycolysis, PPP, TCA cycle and related pathways, reporting enrichment ratios and absolute concentrations.
Bioanalytical support for PK studies and integrated PK/PD analysis including NCA, modeling/simulation, study design optimization, biometrics, and report/manuscript generation.
Develop and optimize LC-MS/MS methods for quantification of metabolites, peptides, and drugs; evaluate matrices, recovery, stability, and interferences; deliver methods for in-house use or transfer to client platforms.
Guidance and execution of bioanalytical validation steps to meet rigorous criteria including QC/QA management, selection of matrices and internal standards, recovery/accuracy/precision testing, and SOP development.
Quantitative panels for intracellular energy metabolites, lipid classes, and a global metabolite panel with absolute or relative quantification using stable-isotope internal standards and multi-point calibration.
High-resolution untargeted profiling to identify differential analytes and candidate biomarkers, followed by identification through database matching, comparison to standards, or ultra-high-resolution analysis.
Design and measurement of 13C tracer incorporation and isotopologue distributions for glycolysis, PPP, TCA cycle and related pathways, reporting enrichment ratios and absolute concentrations.
Bioanalytical support for PK studies and integrated PK/PD analysis including NCA, modeling/simulation, study design optimization, biometrics, and report/manuscript generation.
Expertise Areas
- Targeted metabolomics and lipidomics
- Untargeted metabolomics and biomarker discovery
- Metabolic flux analysis (13C fluxomics)
- LC-MS/MS method development and validation
Key Technologies
- Liquid chromatography–tandem mass spectrometry (LC-MS/MS, triple quadrupole)
- High-resolution mass spectrometry (Q-TOF and ultra-high-resolution MS)
- Stable isotope dilution quantification
- 13C tracer-based isotopologue analysis