Dharmacon
Horizon Discovery is a leading provider of cell engineering solutions, leveraging expertise in gene editing and gene modulation to support scientific research, drug discovery, and therapeutic applications. The company offers a broad portfolio of tools and services, including research reagents, screening and cell line engineering services, bio-production cell lines, and base editing technologies. Horizon's mission is to transform human health through innovative gene editing applications, supported by a strategic focus on expanding tools, growing revenue, automating processes, and continuous innovation. With a global customer base across academia, biotech, and pharma, Horizon aims to be the 'go-to' provider of cell engineering solutions, advancing precision medicine and biopharmaceutical development.
Industries
Nr. of Employees
large (251-1000)
Patents
Optimization of vectors for effective delivery and expression of genetic content
US-9382534-B2
View Details
Optimization of vectors for effective delivery and expression of genetic content
US-9382534-B2
View DetailsProducts
Engineered cell line products (knockout/knock-in/isogenic banks)
Ready-to-ship engineered cell models including a large isogenic HAP1 knockout bank (>7,500 models), cancer-related knock-in/knockout lines and stable Cas9/dCas9 expressing lines.
Gene editing and modulation reagents (CRISPR and RNAi)
Catalog of gene editing and gene modulation reagents including synthetic guide RNAs, nucleases, siRNA/shRNA pools and screening libraries.
cDNA and ORF clone collections
Mammalian and non-mammalian cDNA and ORF clone collections for overexpression studies, available as individual clones, plates, lentiviral ORFs and genome-scale libraries.
Reference standards (cell line-derived)
Molecular reference standards derived from cell lines and custom-designed reference materials to support assay workflow control and diagnostics development.
Transfection and ancillary reagents
Reagents and consumables to support nucleic acid delivery and routine laboratory workflows for gene editing and modulation experiments.
Bioproduction cell lines (CHO platforms)
Engineered CHO expression cell lines and platforms optimized for biologics production including lines designed to enhance antibody-dependent cellular cytotoxicity (ADCC) and other production traits.
Engineered cell line products (knockout/knock-in/isogenic banks)
Ready-to-ship engineered cell models including a large isogenic HAP1 knockout bank (>7,500 models), cancer-related knock-in/knockout lines and stable Cas9/dCas9 expressing lines.
Gene editing and modulation reagents (CRISPR and RNAi)
Catalog of gene editing and gene modulation reagents including synthetic guide RNAs, nucleases, siRNA/shRNA pools and screening libraries.
cDNA and ORF clone collections
Mammalian and non-mammalian cDNA and ORF clone collections for overexpression studies, available as individual clones, plates, lentiviral ORFs and genome-scale libraries.
Reference standards (cell line-derived)
Molecular reference standards derived from cell lines and custom-designed reference materials to support assay workflow control and diagnostics development.
Transfection and ancillary reagents
Reagents and consumables to support nucleic acid delivery and routine laboratory workflows for gene editing and modulation experiments.
Bioproduction cell lines (CHO platforms)
Engineered CHO expression cell lines and platforms optimized for biologics production including lines designed to enhance antibody-dependent cellular cytotoxicity (ADCC) and other production traits.
Services
Arrayed and pooled screening workflows including CRISPR and RNAi screens, single-cell CRISPR screens and pooled tiled base-editing screens.
Custom generation of knockout and knock-in cell models, stable Cas9/dCas9 cell lines and bioproduction cell engineering for CHO platforms.
Custom synthesis of RNA and DNA oligonucleotides including siRNA, ASOs and single-strand RNA.
Assay development and compound screening in immune cell contexts, including T cell activation, regulatory T cell polarization/suppression and mixed lymphocyte reaction assays.
Online calculators and design tools for CRISPR guide design, HDR donor design, primer analysis, Tm calculations and qPCR efficiency estimations.
Design and manufacture of cell line–derived molecular reference standards and custom reference materials for assay validation and diagnostics.
Arrayed and pooled screening workflows including CRISPR and RNAi screens, single-cell CRISPR screens and pooled tiled base-editing screens.
Custom generation of knockout and knock-in cell models, stable Cas9/dCas9 cell lines and bioproduction cell engineering for CHO platforms.
Custom synthesis of RNA and DNA oligonucleotides including siRNA, ASOs and single-strand RNA.
Assay development and compound screening in immune cell contexts, including T cell activation, regulatory T cell polarization/suppression and mixed lymphocyte reaction assays.
Online calculators and design tools for CRISPR guide design, HDR donor design, primer analysis, Tm calculations and qPCR efficiency estimations.
Design and manufacture of cell line–derived molecular reference standards and custom reference materials for assay validation and diagnostics.
Expertise Areas
- Cell line engineering
- Functional genomic screening
- Gene editing and base editing
- RNA interference and gene modulation
Key Technologies
- CRISPR-based gene editing
- Base editing
- CRISPR activation/interference (CRISPRa/CRISPRi)
- RNAi (siRNA, shRNA, microRNA)