Celltheon
Celltheon develops leading edge technologies and innovative solutions for the next generation of biotherapeutics. It offers platformed and custom end-to-end solutions for drug developability, cell line development, and process development, bridging the gap between early drug development and manufacturing. The company has a comprehensive suite of patented technologies and has worked on over 1000 proteins for more than 100 clients globally, with a 100% success track record.
Industries
Nr. of Employees
small (1-50)
Celltheon
Union City, California, United States, North America
Products
CHO-K1 transient expression kit (transient expression system)
A bundled transient expression kit for CHO-K1 designed to increase transient titers and enable scalability; kit components include expression vectors, cells, culture media and a transfection reagent.
Engineered CHO cell lines for high-titer stable expression
Provision of engineered mammalian cell lines developed to support high stable expression and improved folding/metabolism for challenging proteins and biologics.
Engineered expression vector systems and high-capacity integration tools
Expression vector systems containing genetic elements intended to promote homogeneous, high-level expression and high-capacity integration/transposition tools to enable robust clone generation.
CHO-K1 transient expression kit (transient expression system)
A bundled transient expression kit for CHO-K1 designed to increase transient titers and enable scalability; kit components include expression vectors, cells, culture media and a transfection reagent.
Engineered CHO cell lines for high-titer stable expression
Provision of engineered mammalian cell lines developed to support high stable expression and improved folding/metabolism for challenging proteins and biologics.
Engineered expression vector systems and high-capacity integration tools
Expression vector systems containing genetic elements intended to promote homogeneous, high-level expression and high-capacity integration/transposition tools to enable robust clone generation.
Services
Transient protein production and purification (CHO/HEK)
Rapid transient expression, purification and analytical characterization of protein variants for discovery and lead selection, at small to large scale.
Cell line development and stable clone generation
Custom development of high-titer stable pools and clones, clone screening and stability assessment, and preparation of research cell banks and related transfer documentation.
Upstream process development and bioreactor confirmation
Design and optimization of upstream processes using development-scale stirred-tank bioreactors, clone screening in bioreactors, and process confirmation for transfer to larger GMP reactors.
Downstream process development and purification optimization
Development of scalable chromatography-based purification trains, viral inactivation and filtration strategies, clarification and TFF-based formulation workflows.
Analytical method development and GMP method transfer
Creation of biochemical and biophysical assays for CQA measurement and transfer of those methods for GMP qualification/validation.
Cell-based biological assay development and transfer
Design and qualification/transfer of cell-based assays (ADCC, CDC, cytokine release, killing assays, FACS-based assays) for discovery and for IND-enabling development.
Transient protein production and purification (CHO/HEK)
Rapid transient expression, purification and analytical characterization of protein variants for discovery and lead selection, at small to large scale.
Cell line development and stable clone generation
Custom development of high-titer stable pools and clones, clone screening and stability assessment, and preparation of research cell banks and related transfer documentation.
Upstream process development and bioreactor confirmation
Design and optimization of upstream processes using development-scale stirred-tank bioreactors, clone screening in bioreactors, and process confirmation for transfer to larger GMP reactors.
Downstream process development and purification optimization
Development of scalable chromatography-based purification trains, viral inactivation and filtration strategies, clarification and TFF-based formulation workflows.
Analytical method development and GMP method transfer
Creation of biochemical and biophysical assays for CQA measurement and transfer of those methods for GMP qualification/validation.
Cell-based biological assay development and transfer
Design and qualification/transfer of cell-based assays (ADCC, CDC, cytokine release, killing assays, FACS-based assays) for discovery and for IND-enabling development.
Expertise Areas
- Cell line development
- Transient mammalian expression
- Upstream process development and scale-up
- Downstream process and chromatography development
Key Technologies
- CHO-K1 transient expression systems
- HEK293 transient expression
- Engineered CHO cell lines for high-titer production
- Expression vector engineering and genetic stabilizers