ChemoGenics BioPharma
Provider of preclinical drug discovery research and services for pharmaceutical, biotechnology, academic and government clients. Offers integrated capabilities spanning medicinal chemistry, custom chemical synthesis (mg to multi-kg), in vitro ADME, bioanalytical characterization, in vivo PK/PD and disease-model studies, cheminformatics and bioinformatics, plus cGMP process scale-up and technology transfer support.
Industries
Nr. of Employees
small (1-50)
ChemoGenics BioPharma
Durham, North Carolina, United States, North America
Products
Custom Synthesis
Service providing chemical synthesis of compounds tailored to client specifications for drug discovery research.
Pharmacophore Libraries
Provision of collections of pharmacophore models used to identify potential drug candidates through virtual screening.
Medicinal Chemistry
Medicinal chemistry services focused on designing and synthesizing molecules for drug discovery and optimization.
In vitro ADME
Laboratory testing services to assess absorption, distribution, metabolism, and excretion properties of drug candidates in vitro.
In vivo PK/PD
In vivo pharmacokinetics and pharmacodynamics studies to evaluate drug behavior and biological effects in animal models.
Analytical Chemistry
Analytical testing services including compound characterization and purity assessment for drug discovery compounds.
Custom Synthesis
Service providing chemical synthesis of compounds tailored to client specifications for drug discovery research.
Pharmacophore Libraries
Provision of collections of pharmacophore models used to identify potential drug candidates through virtual screening.
Medicinal Chemistry
Medicinal chemistry services focused on designing and synthesizing molecules for drug discovery and optimization.
In vitro ADME
Laboratory testing services to assess absorption, distribution, metabolism, and excretion properties of drug candidates in vitro.
In vivo PK/PD
In vivo pharmacokinetics and pharmacodynamics studies to evaluate drug behavior and biological effects in animal models.
Analytical Chemistry
Analytical testing services including compound characterization and purity assessment for drug discovery compounds.
Services
Custom synthesis
Contract synthesis of small molecules and complex chemical entities from milligram to multi-kilogram scale, including multi-step syntheses, chiral building blocks and library formatting.
Analytical chemistry and bioanalysis
Characterization and purity analysis of small molecules and peptides in biological matrices using LC-MS/MS, GC-MS and high-resolution MS; metabolite identification and bioanalytical quantification to support regulatory submissions.
In vitro ADME profiling
In vitro cytochrome P450 profiling, permeability assays (MDCK/Caco-2), interspecies P450 correlation and mutagenicity testing to inform lead selection and reduce ADME liabilities.
In vivo PK/PD studies
Pharmacokinetic and pharmacodynamic studies in rodents and dogs including formulation evaluation, PK/PD modeling, dose escalation and support for preclinical toxicology planning.
Cheminformatics and CADD services
Structure- and ligand-based computational design including docking, pharmacophore modeling, virtual screening, MD simulation and QSAR.
Bioinformatics and in silico target identification
Data-mining and integration for target identification and validation, pathway annotation/expansion, gene expression analysis and development of integrated knowledge resources.
Custom synthesis
Contract synthesis of small molecules and complex chemical entities from milligram to multi-kilogram scale, including multi-step syntheses, chiral building blocks and library formatting.
Analytical chemistry and bioanalysis
Characterization and purity analysis of small molecules and peptides in biological matrices using LC-MS/MS, GC-MS and high-resolution MS; metabolite identification and bioanalytical quantification to support regulatory submissions.
In vitro ADME profiling
In vitro cytochrome P450 profiling, permeability assays (MDCK/Caco-2), interspecies P450 correlation and mutagenicity testing to inform lead selection and reduce ADME liabilities.
In vivo PK/PD studies
Pharmacokinetic and pharmacodynamic studies in rodents and dogs including formulation evaluation, PK/PD modeling, dose escalation and support for preclinical toxicology planning.
Cheminformatics and CADD services
Structure- and ligand-based computational design including docking, pharmacophore modeling, virtual screening, MD simulation and QSAR.
Bioinformatics and in silico target identification
Data-mining and integration for target identification and validation, pathway annotation/expansion, gene expression analysis and development of integrated knowledge resources.
Expertise Areas
- Medicinal chemistry and lead optimization
- Custom synthesis and process chemistry
- Preclinical ADME/Tox (in vitro and in vivo)
- In vivo pharmacology and disease-model efficacy testing
Key Technologies
- Liquid chromatography-tandem mass spectrometry (LC-MS/MS)
- Triple quadrupole and QTrap mass analyzers
- High-resolution sector-field mass spectrometry
- Gas chromatography-mass spectrometry (GC-MS)