CasZyme
Caszyme is a pioneering biotechnology company specializing in CRISPR gene editing technology. Founded in 2017 in Vilnius, Lithuania, it develops innovative gene editing tools and solutions across various sectors including healthcare, agriculture, diagnostics, and industrial biotech. With a mission to leverage CRISPR to create a healthier, equitable, and sustainable world, Caszyme collaborates with global partners and continuously advances its platform through research, development, and strategic projects. The company values courage, curiosity, collaboration, caring, and commitment to change, aiming to deliver world-class CRISPR solutions tailored to diverse industrial needs.
Industries
Nr. of Employees
small (1-50)
CasZyme
Products
Protein thermostability prediction tool (TemStaPro — publication)
A published computational method using deep learning and protein language models to predict protein thermostability from sequence, validated against experimental data for effector proteins.
CRISPR-based SARS-CoV-2 variant detection prototype
A prototype detection system for SARS-CoV-2 variants using RNA-guided nucleases and isothermal amplification developed and validated during a funded research project.
Protein thermostability prediction tool (TemStaPro — publication)
A published computational method using deep learning and protein language models to predict protein thermostability from sequence, validated against experimental data for effector proteins.
CRISPR-based SARS-CoV-2 variant detection prototype
A prototype detection system for SARS-CoV-2 variants using RNA-guided nucleases and isothermal amplification developed and validated during a funded research project.
Services
CRISPR nuclease discovery and characterization services
Identification and biochemical/functional profiling of novel RNA-guided nucleases for use in research, diagnostics, therapeutics and industrial applications.
mRNA synthesis, template design and QC services
Design and synthesis of mRNA templates with early-stage quality control and potency testing to support gene-editor expression optimization in discovery projects.
Protein engineering and directed evolution programs
Rational design and directed evolution campaigns to improve nuclease activity, specificity and other desired biochemical traits.
CRISPR-based diagnostic assay development
Design, prototyping and analytical validation of CRISPR-based nucleic-acid detection assays, including SNP detection and pathogen testing workflows with isothermal amplification and direct-sample methods.
Verification and validation of editing across delivery formats
Experimental verification and optimization of gene-editing outcomes when delivering editing agents as RNP complexes, mRNA or DNA, across cellular contexts.
Collaborative project management and partnership services
Management and execution of collaborative R&D projects, grant-backed consortia participation, and licensing/partnering to translate discoveries into applications.
CRISPR nuclease discovery and characterization services
Identification and biochemical/functional profiling of novel RNA-guided nucleases for use in research, diagnostics, therapeutics and industrial applications.
mRNA synthesis, template design and QC services
Design and synthesis of mRNA templates with early-stage quality control and potency testing to support gene-editor expression optimization in discovery projects.
Protein engineering and directed evolution programs
Rational design and directed evolution campaigns to improve nuclease activity, specificity and other desired biochemical traits.
CRISPR-based diagnostic assay development
Design, prototyping and analytical validation of CRISPR-based nucleic-acid detection assays, including SNP detection and pathogen testing workflows with isothermal amplification and direct-sample methods.
Verification and validation of editing across delivery formats
Experimental verification and optimization of gene-editing outcomes when delivering editing agents as RNP complexes, mRNA or DNA, across cellular contexts.
Collaborative project management and partnership services
Management and execution of collaborative R&D projects, grant-backed consortia participation, and licensing/partnering to translate discoveries into applications.
Expertise Areas
- CRISPR nuclease discovery and characterization
- Protein engineering and directed evolution
- mRNA synthesis and optimization
- CRISPR-based diagnostic assay development
Key Technologies
- RNA-guided nucleases (CRISPR-Cas family)
- Metagenomic sequence mining
- Bioinformatics and structural protein analysis
- Directed evolution