CRISPR Therapeutics AG


CRISPR Therapeutics is pioneering a new era of medicines by rapidly translating revolutionary gene editing technology into therapies. The company is focused on developing transformative gene-based medicines for serious diseases, with a diverse portfolio across disease areas including hemoglobinopathies, oncology, diabetes, and cardiovascular disease. They have achieved the first-ever approved CRISPR-based therapy and are at the forefront of scientific innovation in gene editing.

Industries

biopharma
biotechnology
genetics
medical

Nr. of Employees

large (251-1000)

CRISPR Therapeutics AG

105 West First Street, South Boston, MA 02127


Patents

Gene-edited natural killer cells

US-12344655-B2

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Genetically engineered T cells having improved persistence in culture

US-12344656-B2

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T-cells expressing anti-LIV1 chimeric antigen receptor

US-12304968-B2

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Optimized mRNA encoding CAS9 for use in LNPs

US-12263227-B2

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Materials and methods for treatment of autosomal dominant retinitis pigmentosa

US-12247201-B2

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Compositions and methods for differentiating stem cells into NK cells

US-12241087-B2

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Products

Gene-edited hematopoietic stem cell therapy for hemoglobinopathies

A CRISPR/Cas-based gene-edited hematopoietic stem cell therapy developed to treat severe sickle cell disease and transfusion-dependent β-thalassemia; reported as authorized for use in some jurisdictions for eligible patients.


Services

Strategic alliances with external biopharma and research organizations to co-develop nucleic acid- and cell-based therapeutic programs.

Programs to engage patient communities, support advocacy groups, and provide information on clinical research and expanded access to investigational medicines.

Expertise Areas

  • Gene editing therapeutics
  • Ex vivo hematopoietic stem cell therapies
  • In vivo genome editing
  • Cell therapy development (oncology and autoimmune)
  • Show More (6)

Key Technologies

  • CRISPR/Cas gene editing
  • Ex vivo HSC editing
  • In vivo genome editing
  • Cell therapy platforms
  • Show More (5)

News & Updates

CASGEVY™ (exagamglogene autotemcel), a CRISPR/Cas9 gene-edited therapy, is approved in some countries for certain eligible patients with sickle cell disease or transfusion-dependent beta thalassemia.


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