Neurotrauma/ Traumatic Brain Injury

Neurotrauma and traumatic brain injury (TBI) capability advances battlefield-relevant diagnosis, monitoring, acute stabilization, and rehabilitation after blast, blunt, and penetrating brain injuries. It integrates point-of-care biomarkers, portable neurophysiology and imaging, neuroprotective therapeutics, and decision-support to enable rapid triage, prolonged field care, and improved neurologic recovery.

Technical Challenges

  • Heterogeneous injury mechanisms (blast, blunt, penetrating) complicating diagnosis and prognosis

  • Limited portable, objective field diagnostics for intracranial pressure, diffuse axonal injury, and evolving hemorrhage

  • Difficulty sustaining definitive neurocritical care during delayed evacuation and prolonged field care

  • Sparse validated biomarkers and standardized algorithms for early brain injury severity and outcome prediction

Emerging Opportunities

  • Rapid, rugged point-of-care assays for blood and biofluid TBI biomarkers with battlefield utility

  • Compact, low-power neuroimaging and continuous neuromonitoring suitable for austere, mobile environments

  • Neuroprotective therapeutics and delivery systems effective when definitive care is delayed

  • Validated AI-enabled decision-support that integrates multimodal physiologic, imaging, and biomarker data for triage

Current and Emerging Technologies in Neurotrauma/ Traumatic Brain Injury

Point-of-care biomarker assays

Rapid assays for proteins (GFAP, UCH-L1), microRNAs, and metabolomic signatures enable early triage and risk stratification of TBI in forward environments.

Portable neurophysiology and brain monitoring

Compact EEG, quantitative pupillometry, transcranial Doppler, and NIRS systems provide continuous, noninvasive measures of cerebral function and hemodynamics at point-of-injury or during transport.

Low-field portable MRI and advanced ultrasound

Emerging low-field MRI and advanced transcranial ultrasound platforms enable improved detection of hemorrhage, contusion, and edema without large infrastructure.

AI-enabled multimodal decision support

Machine learning that fuses physiologic signals, imaging, and biomarkers can provide automated triage, prognostic scoring, and treatment guidance tailored for austere and prolonged care settings.

Neuroprotective therapeutics & targeted delivery

Small molecules, biologics, and repurposed agents with delivery systems (intranasal, nanoparticle) aimed at limiting secondary injury and inflammation when evacuation is delayed.

Rehabilitation technologies and neuromodulation

Wearable neurostimulation, virtual-reality rehabilitation, and cognitive performance tools support recovery and return-to-duty assessments across military and civilian populations.

Importance to Military Medicine

Improve combat casualty outcomes

Timely TBI detection and stabilization reduce mortality, limit secondary brain injury, and preserve neurologic function after blast and polytrauma.

Enable prolonged and distributed care

Portable diagnostics and therapeutics extend critical neurocare when evacuation is delayed or in austere environments, supporting mission success and survivor recovery.

Maintain force readiness

Early detection of concussion and cumulative brain injury informs return-to-duty decisions, long-term care planning, and overall force health protection.

Address complex multi-injury scenarios

Integration with hemorrhage control, resuscitation, and polytrauma management is essential for coordinated trauma care in combat environments.

Alignment with the MTEC Mission

Accelerates translation of military-relevant neurotechnologies from prototypes to operational use through consortium-driven partnerships.

Fosters multidisciplinary collaboration among DoD labs, academia, industry, and clinicians to address complex TBI challenges.

Emphasizes dual-use solutions that provide rapid benefit to Warfighters and downstream civilian healthcare impact.

Dual-Use (Military + Civilian) Applications

Dual-use impact: trauma centers and emergency departments adopt rugged point-of-care diagnostics and monitoring developed for combat care.

Sports medicine and concussion programs benefit from validated biomarkers, wearable neurophysiology, and return-to-play/return-to-duty algorithms.

Stroke and neurocritical care services gain from portable imaging and AI-driven decision support designed for resource-constrained scenarios.

Rehabilitation and telehealth platforms translate to community and veteran care settings to support long-term functional recovery.

Explore MTEC Members with Neurotrauma/ Traumatic Brain Injury Capabilities

MTEC members — spanning academic neurotrauma research, medtech industry, military clinical networks, and translational labs — provide unique strengths in rapid assay development, ruggedization, clinical validation, and regulatory navigation. Explore member profiles to identify collaborators with capabilities in biomarkers, portable neuromonitoring, AI analytics, therapeutics, and rehabilitation technologies.

124 Members with Neurotrauma/ Traumatic Brain Injury capabilities.

Member
The University of Texas System

The University of Texas System is a leading public university system in the United States, dedicated to improving lives through education, health care, and research. With over 256,000 students enrolled across 14 institutions, the UT System is committed to providing affordable access to higher education and producing a skilled workforce to drive Texas's economy.

Member
Georgia Southern University

Georgia Southern University is a vibrant institution with over 26,100 students across three campuses in Statesboro, Savannah, and Hinesville. The university offers 132 degree programs at the associate, bachelor’s, master’s, and doctorate levels, emphasizing student success, community impact, and research excellence. With a commitment to inclusivity and engagement, Georgia Southern fosters a supportive environment for diverse learners, including military-affiliated and adult students. The university is dedicated to transforming lives through education and community engagement, aligning its programs with regional needs. Additionally, Georgia Southern provides accelerated pathways for students to fast-track their master's degrees, enhancing educational opportunities. The university also emphasizes career readiness and public impact research, preparing students for successful careers and contributing to community development.

Member
Volatylix, Inc

Volatylix, a Cambridge, MA based startup, is dedicated to early diagnosis enabling timely and appropriate treatment benefiting the patient, physician, provider and payor. Our patent pending platform – DECIPHER – and unique detection sensor technology – OFIS - combine to identify various disease states and conditions via proprietary breath biomarkers, volatile organic compounds (VOC’s). DECIPHER is disease agnostic and will speed diagnosis, while improving accuracy over currently available diagnostic methods. The tests use a noninvasive 4-minute breath sample with analysis taking ~15 minutes on our portable, battery powered platform. Initial products include fungal pneumonias, lung cancer (staging, monitoring, differential diagnosis and screening) and C. difficile.

Member
FiteBac Pharma

FiteBac Technology/FiteBac Pharma's K21 uniquely targets the underlying disease state, given that most diseases involve microbial-associated inflammation and mitochondrial dysfunction. FiteBac Technology innovations stem from the work of numerous international academic research scientists. FiteBac Pharma K21 is the blockbuster antimicrobial small molecule designed to modulate biological, immunological, and metabolic systems for treating a wide range of infectious and inflammatory diseases. This patented drug substance has demonstrated the ability to safely eliminate bacterial, fungal, and viral infections, enhance innate immunity, induce mitophagy while improving mitochondrial and cellular metabolism, accelerate wound healing, and even promote the development of zebrafish and chickens, leading to increased adult mass. Rigorous research from Dr. Bhupesh Prusty's laboratory and Dr Christopher Rongo's laboratory is focused on various aspects of mitochondrial remodeling and reprograming, as well as mitochondrial-to-nuclear signaling with K21.

Member
NervGen Pharma Corp

NervGen Pharma Corp is a clinical-stage biotech company focused on developing innovative treatments to enable nervous system repair in cases of traumatic injury and disease. Their lead drug candidate, NVG-291, is currently being evaluated in a Phase 1b/2a clinical trial for spinal cord injury, with additional preclinical evaluations for conditions such as ischemic stroke and amyotrophic lateral sclerosis (ALS). The company is also advancing a new development candidate, NVG-300, in preclinical studies.

Member
The University of Texas at San Antonio

The University of Texas at San Antonio (UTSA) is dedicated to the advancement of knowledge through research, teaching, and community engagement. As a premier public research university, UTSA embraces multicultural traditions and serves as a catalyst for socioeconomic development, providing access to educational excellence and preparing citizen leaders for the global environment.

Member
Auburn University

Auburn University Research & Economic Development is dedicated to advancing research and economic growth through a collaborative effort among its various colleges and departments. The organization focuses on fostering innovation, supporting faculty and student research, and facilitating partnerships with industry and government to address societal challenges and enhance the quality of life. Recent initiatives include the launch of the Team Science Series to promote interdisciplinary collaboration and the development of the Gulf Coast Engineering Research Station to address coastal environmental challenges.

Member
Institute for Integrative & Innovative Research (I³R) at University of Arkansas

The Institute for Integrative & Innovative Research (I³R) at the University of Arkansas is dedicated to pioneering solutions to wicked problems and societal challenges through convergence research. With a mission to advance research excellence and stimulate economic development, I³R focuses on deploying innovations at scale through collaboration across various sectors, including academia, industry, and government.

Member
The University of Texas Medical Branch at Galveston

UTMB is dedicated to supporting research, education, and scholarly endeavors, with a focus on creating the future of healthcare through innovative research and community engagement.

Member
Neuraptive Therapeutics, Inc.

Neuraptive Therapeutics is a biotechnology company focused on developing novel therapies to improve outcomes in peripheral nerve injuries (PNI). Their mission is to enhance the quality and speed of recovery for patients suffering from traumatic injuries or undergoing reconstructive surgeries, utilizing innovative technologies such as NTX-001, a nerve fusion system, and specialized microsurgical instruments.

Member
Tulane University Center for Brain Health (TUCBH)

Tulane University Center for Brain Health (TUCBH) is dedicated to advancing brain health and wellness, with a particular focus on the diagnosis, treatment, and prevention of mild traumatic brain injuries (mTBI), commonly known as concussions. Serving a diverse population—including military personnel, first responders, athletes, workers in high-risk occupations, civilians, and older adults—TUCBH employs a multidisciplinary approach to restore function, renew hope, and help patients reclaim their quality of life after brain injury. The center is recognized for its expertise, high-quality service, and comprehensive care.

Member
CranioSense, Inc.

CranioSense, Inc. is a clinical stage medical device company developing a non invasive technology designed to support rapid assessment of intracranial hypertension at the point of care. Built for use by emergency care teams, the system integrates into the triage workflow, providing a quick and low risk screening tool to help identify patients who may require further diagnostic evaluation. By delivering actionable information within minutes without the need for invasive procedures or specialized expertise, CranioSense aims to improve triage, accelerate clinical decision making, and enhance patient outcomes in time critical neurological care.

Member
The University of Chicago

The University of Chicago is a prestigious urban research university committed to rigorous inquiry and intellectual freedom. Founded in 1890, it has produced numerous Nobel laureates and is known for its transformative education and groundbreaking research across various fields. The university fosters an inclusive and diverse learning environment, encouraging participation from all community members.

Member
Memsel

Memsel is a biotechnology research and development company dedicated to enhancing health and combatting infections through advanced phage therapies and targeted delivery systems. The company aims to transform healthcare solutions across human, animal, and plant domains, addressing critical health challenges and antibiotic resistance.

Member
Boston University

Boston University is a major research institution committed to leading breakthroughs across various disciplines. The Office of Research supports and advances research excellence, fostering collaboration among researchers, industry partners, and government leaders to address significant societal challenges.

Member
Astrocyte Pharmaceuticals Inc.

Astrocyte Pharmaceuticals Inc. is a clinical-stage biopharmaceutical company dedicated to developing innovative neuroprotection therapies for traumatic brain injuries (TBI), concussions, stroke, and neurodegenerative disorders. The company focuses on harnessing the potential of astrocytes, the brain's natural caretaker cells, to treat brain injuries and diseases. Their flagship program, AST-004, aims to significantly reduce early brain damage and is currently in Phase 2 clinical trials.

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NIRSense

Rugged Physiological Monitoring for the Modern Warfighter: NIRSense

Under MTEC-21-10-NavyMultiTopic, NIRSense is advancing its tactical jet physiological monitoring technology for broader Navy applications. The project focuses on ruggedized, wireless physiological sensors that can provide reliable, real-time insight into warfighter health and performance in demanding operational environments.

Safi Biotherapeutics

Next-Generation Manufactured Red Blood Cells for Extended Battlefield Blood Supply: Safi Biotherapeutics

Safi Biotherapeutics is developing manufactured red blood cells (mRBCs) with extended shelf life to improve battlefield transfusion readiness and emergency trauma care.

Non-Invasive Glymphatic (GF) Monitoring and Recovery Optimization for Warfighter Cognitive Readiness

Applied Cognition is developing non-invasive glymphatic monitoring and recovery technologies to enhance warfighter cognitive readiness, resilience, and sleep recovery.

Moberg Analytics

Moberg Analytics – Advanced Brain Monitoring & Critical Care Informatic

Moberg’s platform unifies brain monitoring data for faster, precise treatment of severe brain injuries in military and civilian care.

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