Neurotrauma/ Traumatic Brain Injury

Neurotrauma and traumatic brain injury (TBI) capability advances battlefield-relevant diagnosis, monitoring, acute stabilization, and rehabilitation after blast, blunt, and penetrating brain injuries. It integrates point-of-care biomarkers, portable neurophysiology and imaging, neuroprotective therapeutics, and decision-support to enable rapid triage, prolonged field care, and improved neurologic recovery.

Technical Challenges

  • Heterogeneous injury mechanisms (blast, blunt, penetrating) complicating diagnosis and prognosis

  • Limited portable, objective field diagnostics for intracranial pressure, diffuse axonal injury, and evolving hemorrhage

  • Difficulty sustaining definitive neurocritical care during delayed evacuation and prolonged field care

  • Sparse validated biomarkers and standardized algorithms for early brain injury severity and outcome prediction

Emerging Opportunities

  • Rapid, rugged point-of-care assays for blood and biofluid TBI biomarkers with battlefield utility

  • Compact, low-power neuroimaging and continuous neuromonitoring suitable for austere, mobile environments

  • Neuroprotective therapeutics and delivery systems effective when definitive care is delayed

  • Validated AI-enabled decision-support that integrates multimodal physiologic, imaging, and biomarker data for triage

Current and Emerging Technologies in Neurotrauma/ Traumatic Brain Injury

Point-of-care biomarker assays

Rapid assays for proteins (GFAP, UCH-L1), microRNAs, and metabolomic signatures enable early triage and risk stratification of TBI in forward environments.

Portable neurophysiology and brain monitoring

Compact EEG, quantitative pupillometry, transcranial Doppler, and NIRS systems provide continuous, noninvasive measures of cerebral function and hemodynamics at point-of-injury or during transport.

Low-field portable MRI and advanced ultrasound

Emerging low-field MRI and advanced transcranial ultrasound platforms enable improved detection of hemorrhage, contusion, and edema without large infrastructure.

AI-enabled multimodal decision support

Machine learning that fuses physiologic signals, imaging, and biomarkers can provide automated triage, prognostic scoring, and treatment guidance tailored for austere and prolonged care settings.

Neuroprotective therapeutics & targeted delivery

Small molecules, biologics, and repurposed agents with delivery systems (intranasal, nanoparticle) aimed at limiting secondary injury and inflammation when evacuation is delayed.

Rehabilitation technologies and neuromodulation

Wearable neurostimulation, virtual-reality rehabilitation, and cognitive performance tools support recovery and return-to-duty assessments across military and civilian populations.

Importance to Military Medicine

Improve combat casualty outcomes

Timely TBI detection and stabilization reduce mortality, limit secondary brain injury, and preserve neurologic function after blast and polytrauma.

Enable prolonged and distributed care

Portable diagnostics and therapeutics extend critical neurocare when evacuation is delayed or in austere environments, supporting mission success and survivor recovery.

Maintain force readiness

Early detection of concussion and cumulative brain injury informs return-to-duty decisions, long-term care planning, and overall force health protection.

Address complex multi-injury scenarios

Integration with hemorrhage control, resuscitation, and polytrauma management is essential for coordinated trauma care in combat environments.

Alignment with the MTEC Mission

Accelerates translation of military-relevant neurotechnologies from prototypes to operational use through consortium-driven partnerships.

Fosters multidisciplinary collaboration among DoD labs, academia, industry, and clinicians to address complex TBI challenges.

Emphasizes dual-use solutions that provide rapid benefit to Warfighters and downstream civilian healthcare impact.

Dual-Use (Military + Civilian) Applications

Dual-use impact: trauma centers and emergency departments adopt rugged point-of-care diagnostics and monitoring developed for combat care.

Sports medicine and concussion programs benefit from validated biomarkers, wearable neurophysiology, and return-to-play/return-to-duty algorithms.

Stroke and neurocritical care services gain from portable imaging and AI-driven decision support designed for resource-constrained scenarios.

Rehabilitation and telehealth platforms translate to community and veteran care settings to support long-term functional recovery.

Explore MTEC Members with Neurotrauma/ Traumatic Brain Injury Capabilities

MTEC members — spanning academic neurotrauma research, medtech industry, military clinical networks, and translational labs — provide unique strengths in rapid assay development, ruggedization, clinical validation, and regulatory navigation. Explore member profiles to identify collaborators with capabilities in biomarkers, portable neuromonitoring, AI analytics, therapeutics, and rehabilitation technologies.

94 Members with Neurotrauma/ Traumatic Brain Injury capabilities.

Member
Georgia Southern University

Georgia Southern University is a vibrant institution with over 26,100 students across three campuses in Statesboro, Savannah, and Hinesville. The university offers 132 degree programs at the associate, bachelor’s, master’s, and doctorate levels, emphasizing student success, community impact, and research excellence. With a commitment to inclusivity and engagement, Georgia Southern fosters a supportive environment for diverse learners, including military-affiliated and adult students. The university is dedicated to transforming lives through education and community engagement, aligning its programs with regional needs. Additionally, Georgia Southern provides accelerated pathways for students to fast-track their master's degrees, enhancing educational opportunities. The university also emphasizes career readiness and public impact research, preparing students for successful careers and contributing to community development.

Member
Volatylix, Inc

Volatylix, a Cambridge, MA based startup, is dedicated to early diagnosis enabling timely and appropriate treatment benefiting the patient, physician, provider and payor. Our patent pending platform – DECIPHER – and unique detection sensor technology – OFIS - combine to identify various disease states and conditions via proprietary breath biomarkers, volatile organic compounds (VOC’s). DECIPHER is disease agnostic and will speed diagnosis, while improving accuracy over currently available diagnostic methods. The tests use a noninvasive 4-minute breath sample with analysis taking ~15 minutes on our portable, battery powered platform. Initial products include fungal pneumonias, lung cancer (staging, monitoring, differential diagnosis and screening) and C. difficile.

Member
FiteBac Pharma

FiteBac Technology/FiteBac Pharma's K21 uniquely targets the underlying disease state, given that most diseases involve microbial-associated inflammation and mitochondrial dysfunction. FiteBac Technology innovations stem from the work of numerous international academic research scientists. FiteBac Pharma K21 is the blockbuster antimicrobial small molecule designed to modulate biological, immunological, and metabolic systems for treating a wide range of infectious and inflammatory diseases. This patented drug substance has demonstrated the ability to safely eliminate bacterial, fungal, and viral infections, enhance innate immunity, induce mitophagy while improving mitochondrial and cellular metabolism, accelerate wound healing, and even promote the development of zebrafish and chickens, leading to increased adult mass. Rigorous research from Dr. Bhupesh Prusty's laboratory and Dr Christopher Rongo's laboratory is focused on various aspects of mitochondrial remodeling and reprograming, as well as mitochondrial-to-nuclear signaling with K21.

Member
NervGen Pharma Corp

NervGen Pharma Corp is a clinical-stage biotech company focused on developing innovative treatments to enable nervous system repair in cases of traumatic injury and disease. Their lead drug candidate, NVG-291, is currently being evaluated in a Phase 1b/2a clinical trial for spinal cord injury, with additional preclinical evaluations for conditions such as ischemic stroke and amyotrophic lateral sclerosis (ALS). The company is also advancing a new development candidate, NVG-300, in preclinical studies.

Member
Auburn University

Auburn University Research & Economic Development is dedicated to advancing research and economic growth through a collaborative effort among its various colleges and departments. The organization focuses on fostering innovation, supporting faculty and student research, and facilitating partnerships with industry and government to address societal challenges and enhance the quality of life. Recent initiatives include the launch of the Team Science Series to promote interdisciplinary collaboration and the development of the Gulf Coast Engineering Research Station to address coastal environmental challenges.

Member
University of Arkansas

The Institute for Integrative & Innovative Research (I3R) at the University of Arkansas is dedicated to pioneering solutions to complex societal challenges through convergence research. With a mission to advance research excellence and stimulate economic development, I3R focuses on deploying innovations at scale through collaboration across various sectors, including academia, industry, and government.

Member
Neuraptive Therapeutics, Inc.

Neuraptive Therapeutics is a biotechnology company focused on developing novel therapies to improve outcomes in peripheral nerve injuries (PNI). Their mission is to enhance the quality and speed of recovery for patients suffering from traumatic injuries or undergoing reconstructive surgeries, utilizing innovative technologies such as NTX-001, a nerve fusion system, and specialized microsurgical instruments.

Member
Tulane University Center for Brain Health (TUCBH)

Tulane University Center for Brain Health (TUCBH) is dedicated to advancing brain health and wellness, with a particular focus on the diagnosis, treatment, and prevention of mild traumatic brain injuries (mTBI), commonly known as concussions. Serving a diverse population—including military personnel, first responders, athletes, workers in high-risk occupations, civilians, and older adults—TUCBH employs a multidisciplinary approach to restore function, renew hope, and help patients reclaim their quality of life after brain injury. The center is recognized for its expertise, high-quality service, and comprehensive care.

Member
CranioSense, Inc.

CranioSense, Inc. is a clinical stage company focused on revolutionizing the measurement of intracranial pressure (ICP) with their innovative IPASS technology. This non-invasive solution aims to provide rapid and safe ICP assessments, addressing the critical need for better management of traumatic brain injury (TBI) and other conditions associated with elevated cranial pressure. By eliminating the need for invasive procedures, CranioSense is poised to significantly improve patient outcomes and healthcare practices.

Member
The University of Chicago

The University of Chicago is a prestigious urban research university committed to rigorous inquiry and intellectual freedom. Founded in 1890, it has produced numerous Nobel laureates and is known for its transformative education and groundbreaking research across various fields. The university fosters an inclusive and diverse learning environment, encouraging participation from all community members.

Member
Memsel

Memsel is a biotechnology research and development company dedicated to enhancing health and combatting infections through advanced phage therapies and targeted delivery systems. The company aims to transform healthcare solutions across human, animal, and plant domains, addressing critical health challenges and antibiotic resistance.

Member
Boston University

Boston University is a major research institution committed to leading breakthroughs across various disciplines. The Office of Research supports and advances research excellence, fostering collaboration among researchers, industry partners, and government leaders to address significant societal challenges.

Member
Astrocyte Pharmaceuticals Inc.

Astrocyte Pharmaceuticals Inc. is a clinical-stage biopharmaceutical company dedicated to developing innovative neuroprotection therapies for traumatic brain injuries (TBI), concussions, stroke, and neurodegenerative disorders. The company focuses on harnessing the potential of astrocytes, the brain's natural caretaker cells, to treat brain injuries and diseases. Their flagship program, AST-004, aims to significantly reduce early brain damage and is currently in Phase 2 clinical trials.

Member
Cooper University Health Care

Cooper University Health Care is a regional academic health system recognized for comprehensive clinical services, advanced multidisciplinary care, specialized surgery, and robust research in South Jersey. It provides integrated healthcare across general and specialty domains, including cancer, neurosciences, cardiology, trauma, genetics, addiction medicine, and complex surgical procedures, supported by leading technologies and a network of modern facilities.

Member
Baylor University

Baylor University is a preeminent Christian research university committed to addressing the world's most meaningful challenges through top-tier research and scholarship. Recognized as an R1 research institution, Baylor focuses on infusing its distinct Christian mission into its research initiatives, fostering a commitment to excellence and innovation.

Member
Sana Health

Military Operational Medicine funded for PTSD, Adjustment Disorder and Pain and Sleep (over $5m). 3 trials in progress. Sana Health is an FDA Breakthrough Designated Device, currently in front of the FDA for Neuropathic Pain as a de novo - expecting to be on market Q4 2025. Sana is a wearable audiovisual neuromodulation device, that provides anxiety and pain relief, and sleep on demand. $25m raised to date, and in the middle of a Series A extension SAFE note round.

We are here to help

Can’t find what you’re looking for?

Projects

Technology Showcase

See All Projects

University of California San Francisco

TemPredict: AI-Driven Wearable Monitoring for Early Illness Detection and Warfighter Readiness

TemPredict: AI wearables detect early illness and health risks to support warfighter readiness.

Arizona State University

ASU Crosscutting Technologies to Enhance Military Medical Readiness and Resilience

Dr. Rachel Cassalia leads MTEC-supported efforts at ASU to shift military health from reactive care to proactive readiness through data-driven prevention.

University of Pittsburgh

Topical Metformin Lotion for Tendinopathy Prevention

University of Pittsburgh study shows topical metformin prevents overuse tendon injury. This work was sponsored through MTEC project 22-02-MPAI-014.

Theradaptive

Theradaptive’s RESTORE Trial Initiation for OsteoAdapt™ DE

Theradaptive launches RESTORE Phase I/II trial of OsteoAdapt™ DE for faster, precision bone healing in craniofacial injuries. MTEC-funded study targets improved recovery for military and civilian patients.

JOIN OUR MAILING LIST

Stay Connected with MTEC

Keep up with active and upcoming solicitations, MTEC news and other valuable information.