Signature Science, LLC
Signature Science, LLC is a multidisciplinary applied science and technology company dedicated to solving the toughest forensic, biosecurity, and public health challenges. Serving both government and commercial clients, Signature Science combines scientific rigor with proven quality assurance to enhance the credibility and defensibility of programs in national security, public safety, and health security. The company is recognized for its innovation, technical excellence, and commitment to advancing the state-of-the-art in forensic science, genomics, and biosecurity technologies. Signature Science also offers advanced bioinformatics and microbiome analysis services, empowering clients with data-driven insights to address emerging threats, pandemics, and bioterrorism. The company is a subsidiary of Southwest Research Institute and is committed to community engagement and workforce development.
Industries
Nr. of Employees
medium (51-250)
Signature Science, LLC
8501 North Mopac Expressway, Suite 100, Austin, TX 78759
Patents
Swab canister equipped with moisture permeable membrane and dessicant
2019-08-27 • US-10391494-B2
View Details
Swab canister equipped with moisture permeable membrane and dessicant
2019-08-27 • US-10391494-B2
View DetailsProducts
Open-source sequence screening software and curated databases
An open-source pipeline for screening nucleotide and protein sequences with configurable sensitivity/speed modes and long-read support, producing annotated outputs and structured reports that integrate curated functional labels.
Laboratory proficiency testing products and schemes
Proficiency testing materials and programs to assess laboratory performance and support quality assurance across forensic and analytical workflows.
Sampling and sample-preparation hardware
Engineered sampling modules and sample-preparation components for environmental and forensic collection, including aerosol and vapor modules, swab containment canisters, mixing chambers, and thermal desorption assemblies.
Open-source sequence screening software and curated databases
An open-source pipeline for screening nucleotide and protein sequences with configurable sensitivity/speed modes and long-read support, producing annotated outputs and structured reports that integrate curated functional labels.
Laboratory proficiency testing products and schemes
Proficiency testing materials and programs to assess laboratory performance and support quality assurance across forensic and analytical workflows.
Sampling and sample-preparation hardware
Engineered sampling modules and sample-preparation components for environmental and forensic collection, including aerosol and vapor modules, swab containment canisters, mixing chambers, and thermal desorption assemblies.
Expertise Areas
- Forensic DNA analysis and complex mixture interpretation
- Functional sequence screening and biosecurity review
- Metagenomic and microbiome sequencing analysis
- CBRNE sampling, detection, and analytical method development
Key Technologies
- Short-read and long-read sequencing
- Open-source sequence functional screening pipelines
- Per-read sensitive alignment (nucleotide and amino-acid space)
- Ensemble machine learning for functional annotation
Key People
Director, Forensic DNA Laboratory
Senior Scientist
Director, Operational Solutions and Threat Reduction
Genomics Research Scientist
Quality Assurance Chemist
Genomics Specialist
Director, Forensic DNA Laboratory
Senior Scientist
Director, Operational Solutions and Threat Reduction
Genomics Research Scientist
Quality Assurance Chemist
Genomics Specialist
News & Updates
Signature Science’s Advanced Genomics Laboratory has been accredited by the ANSI National Accreditation Board (ANAB) to the ISO/IEC 17025:2017 quality standard for forensic testing of Single-Nucleotide Polymorphisms (SNPs).
A preprint analyzing nucleic acid synthesis as a dual-use technology, assessing the risks and benefits of synthetic nucleic acids and their potential for harm or misuse.
An article discussing the importance of screening synthetic nucleic acid orders for sequences of concern, focusing on demonstrated pathogenic function to improve biosecurity.
Newsletter announcing the accreditation of Signature Science’s Advanced Genomics Laboratory by the ANSI National Accreditation Board (ANAB) to the ISO/IEC 17025:2017 quality standard for forensic testing of Single-Nucleotide Polymorphisms (SNPs).
Shaping the Future US Bioeconomy through Safety, Security, Sustainability, and Social Responsibility
A supporting publication in Trends in Biotechnology discussing the importance of safety, security, and social responsibility in the US bioeconomy.
Signature Science will participate in the 2025 CBRN Defense Conference in Baltimore, MD. President & CEO Brian Schimmoller will speak on the panel 'Industry Perspective on Government Contracting Process.' The company will also showcase Far Forward Biological Sequencing capabilities.
Signature Science’s Advanced Genomics Laboratory has been accredited by the ANSI National Accreditation Board (ANAB) to the ISO/IEC 17025:2017 quality standard for forensic testing of Single-Nucleotide Polymorphisms (SNPs).
A preprint analyzing nucleic acid synthesis as a dual-use technology, assessing the risks and benefits of synthetic nucleic acids and their potential for harm or misuse.
An article discussing the importance of screening synthetic nucleic acid orders for sequences of concern, focusing on demonstrated pathogenic function to improve biosecurity.
Newsletter announcing the accreditation of Signature Science’s Advanced Genomics Laboratory by the ANSI National Accreditation Board (ANAB) to the ISO/IEC 17025:2017 quality standard for forensic testing of Single-Nucleotide Polymorphisms (SNPs).
Shaping the Future US Bioeconomy through Safety, Security, Sustainability, and Social Responsibility
A supporting publication in Trends in Biotechnology discussing the importance of safety, security, and social responsibility in the US bioeconomy.
Signature Science will participate in the 2025 CBRN Defense Conference in Baltimore, MD. President & CEO Brian Schimmoller will speak on the panel 'Industry Perspective on Government Contracting Process.' The company will also showcase Far Forward Biological Sequencing capabilities.