Fungal

Fungal capability advances rapid, field‑adapted diagnostics, targeted antifungal therapeutics, biofilm and wound management, and resistance surveillance. Priorities include point‑of‑injury detection, durable therapies for delayed evacuation or prolonged care, and prevention strategies suited to austere military environments.

Technical Challenges

  • Delayed or missed diagnosis of invasive and wound-associated fungal infections in polytrauma and burn patients.

  • Antifungal resistance and limited therapeutic options with adverse effects and complex dosing.

  • Fungal biofilms on wounds, implants, and dressings that resist conventional therapy and impede healing.

  • Lack of rugged, rapid point‑of‑care diagnostics validated for austere and prolonged‑field care settings.

Emerging Opportunities

  • Portable, rapid tests (molecular/antigen/CRISPR) that detect diverse pathogenic fungi at point of injury.

  • Broadly effective, shelf‑stable antifungals or adjunctive therapies with favorable PK/PD for austere use.

  • Biofilm‑targeted wound dressings, coatings, and enzymatic or immune adjuncts that can be deployed forward.

  • Integrated surveillance and stewardship tools to track resistance, identify outbreaks, and maintain force readiness.

Current and Emerging Technologies in Fungal

Rapid molecular and isothermal diagnostics

Portable PCR, LAMP, and CRISPR‑based assays enabling species identification and resistance markers at the point of care to guide timely antifungal therapy.

Antigen and biomarker point‑of‑care tests

Lateral‑flow and microfluidic antigen tests and host biomarker panels for rapid triage of invasive mycoses in low‑resource settings.

Next‑generation sequencing & metagenomics

Rapid sequencing and bioinformatics for pathogen discovery, mixed infections, and surveillance of emerging resistance in deployed populations.

Novel antifungals and repurposed therapeutics

Small molecules, host‑directed therapies, and drug‑repurposing approaches designed for efficacy, tolerability, and simplified dosing in prolonged‑care scenarios.

Anti‑biofilm materials and wound technologies

Antifungal coatings, impregnated dressings, enzymatic dispersal agents, and localized delivery systems to prevent and disrupt fungal biofilms in traumatic wounds and implants.

Immunotherapies and vaccines

Passive and active immune interventions that enhance host clearance, reduce invasive disease, and could be integrated into readiness‑focused preventive strategies.

Importance to Military Medicine

Combat casualty care and wound infection prevention

Traumatic injuries, burns, and blast wounds are prone to environmental fungal contamination; rapid detection and targeted therapy reduce morbidity and preserve limb and life in polytrauma cases.

Prolonged and delayed‑evacuation care

When evacuation is delayed, durable diagnostics and field‑appropriate antifungals are essential to prevent progression of invasive mycoses during prolonged‑field care.

Austere environments and logistics constraints

Solutions must be rugged, low‑power, shelf‑stable, and simple to use by medics under constrained supply chains and variable environmental conditions.

Force readiness and public health

Preventing and rapidly controlling fungal outbreaks preserves operational capability and has direct civilian benefit for hospitals and disaster response systems.

Alignment with the MTEC Mission

This capability aligns with MTEC’s DoD mission to accelerate translation of medical technologies that improve Warfighter survival and readiness, while delivering civilian healthcare benefits.

Cross‑disciplinary approaches—combining diagnostics, therapeutics, materials science, and surveillance—mirror MTEC’s portfolio model for rapid, practical solutions.

Emphasis on rugged, deployable technologies and dual‑use impact supports MTEC priorities for force health protection and broad societal benefit.

Dual-Use (Military + Civilian) Applications

Point‑of‑injury testing for triage and therapeutic decision‑making in forward surgical teams and medevac.

Prolonged‑field care treatment kits with shelf‑stable antifungals and biofilm‑disrupting dressings for delayed evacuation scenarios.

Surveillance platforms integrating sequencing and resistance data to inform stewardship, outbreak response, and readiness planning.

Civilian translation for burn centers, trauma hospitals, and public health systems facing emerging fungal threats and AMR.

Explore MTEC Members with Fungal Capabilities

MTEC members bring complementary strengths—industry scale‑up and manufacturing, academic discovery and translational science, military clinical expertise, and regulatory and field‑validation capabilities—to accelerate fieldable fungal solutions.

Explore member profiles to identify partners with diagnostics, wound‑care materials, antifungal drug development, sequencing analytics, or clinical trial infrastructure to tackle fungal challenges from bench to battlefield.

112 Members with Fungal capabilities.

The University of Texas System
The University of Texas System

The University of Texas System is a leading public university system in the United States, dedicated to improving lives through education, health care, and research. With over 256,000 students enrolled across 14 institutions, the UT System is committed to providing affordable access to higher education and producing a skilled workforce to drive Texas's economy.

Georgia Southern University
Georgia Southern University

Georgia Southern University is a vibrant institution with over 26,100 students across three campuses in Statesboro, Savannah, and Hinesville. The university offers 132 degree programs at the associate, bachelor’s, master’s, and doctorate levels, emphasizing student success, community impact, and research excellence. With a commitment to inclusivity and engagement, Georgia Southern fosters a supportive environment for diverse learners, including military-affiliated and adult students. The university is dedicated to transforming lives through education and community engagement, aligning its programs with regional needs. Additionally, Georgia Southern provides accelerated pathways for students to fast-track their master's degrees, enhancing educational opportunities. The university also emphasizes career readiness and public impact research, preparing students for successful careers and contributing to community development.

Volatylix, Inc
Volatylix, Inc

Volatylix, a Cambridge, MA based startup, is dedicated to early diagnosis enabling timely and appropriate treatment benefiting the patient, physician, provider and payor. Our patent pending platform – DECIPHER – and unique detection sensor technology – OFIS - combine to identify various disease states and conditions via proprietary breath biomarkers, volatile organic compounds (VOC’s). DECIPHER is disease agnostic and will speed diagnosis, while improving accuracy over currently available diagnostic methods. The tests use a noninvasive 4-minute breath sample with analysis taking ~15 minutes on our portable, battery powered platform. Initial products include fungal pneumonias, lung cancer (staging, monitoring, differential diagnosis and screening) and C. difficile.

FiteBac Pharma
FiteBac Pharma

FiteBac Technology/FiteBac Pharma's K21 uniquely targets the underlying disease state, given that most diseases involve microbial-associated inflammation and mitochondrial dysfunction. FiteBac Technology innovations stem from the work of numerous international academic research scientists. FiteBac Pharma K21 is the blockbuster antimicrobial small molecule designed to modulate biological, immunological, and metabolic systems for treating a wide range of infectious and inflammatory diseases. This patented drug substance has demonstrated the ability to safely eliminate bacterial, fungal, and viral infections, enhance innate immunity, induce mitophagy while improving mitochondrial and cellular metabolism, accelerate wound healing, and even promote the development of zebrafish and chickens, leading to increased adult mass. Rigorous research from Dr. Bhupesh Prusty's laboratory and Dr Christopher Rongo's laboratory is focused on various aspects of mitochondrial remodeling and reprograming, as well as mitochondrial-to-nuclear signaling with K21.

The University of Texas at San Antonio
The University of Texas at San Antonio

The University of Texas at San Antonio (UTSA) is dedicated to the advancement of knowledge through research, teaching, and community engagement. As a premier public research university, UTSA embraces multicultural traditions and serves as a catalyst for socioeconomic development, providing access to educational excellence and preparing citizen leaders for the global environment.

Auburn University
Auburn University

Auburn University Research & Economic Development is dedicated to advancing research and economic growth through a collaborative effort among its various colleges and departments. The organization focuses on fostering innovation, supporting faculty and student research, and facilitating partnerships with industry and government to address societal challenges and enhance the quality of life. Recent initiatives include the launch of the Team Science Series to promote interdisciplinary collaboration and the development of the Gulf Coast Engineering Research Station to address coastal environmental challenges.

University of Arkansas
University of Arkansas

The Institute for Integrative & Innovative Research (I3R) at the University of Arkansas is dedicated to pioneering solutions to complex societal challenges through convergence research. With a mission to advance research excellence and stimulate economic development, I3R focuses on deploying innovations at scale through collaboration across various sectors, including academia, industry, and government.

The University of Texas Medical Branch at Galveston
The University of Texas Medical Branch at Galveston

UTMB is dedicated to supporting research, education, and scholarly endeavors, with a focus on creating the future of healthcare through innovative research and community engagement.

The University of Queensland
The University of Queensland

The University of Queensland (UQ) is one of Australia's leading research and teaching institutions, dedicated to transforming lives through education and research. UQ aims to create a better future by equipping students with the skills and knowledge necessary for their chosen careers, while also addressing some of the world's most complex challenges through innovative research.

The University of Chicago
The University of Chicago

The University of Chicago is a prestigious urban research university committed to rigorous inquiry and intellectual freedom. Founded in 1890, it has produced numerous Nobel laureates and is known for its transformative education and groundbreaking research across various fields. The university fosters an inclusive and diverse learning environment, encouraging participation from all community members.

Boston University
Boston University

Boston University is a major research institution committed to leading breakthroughs across various disciplines. The Office of Research supports and advances research excellence, fostering collaboration among researchers, industry partners, and government leaders to address significant societal challenges.

Baylor University
Baylor University

Baylor University is a preeminent Christian research university committed to addressing the world's most meaningful challenges through top-tier research and scholarship. Recognized as an R1 research institution, Baylor focuses on infusing its distinct Christian mission into its research initiatives, fostering a commitment to excellence and innovation.

Maxwell Biosciences
Maxwell Biosciences

Founded in 2016, Maxwell Biosciences is a preclinical stage biotechnology company focused on developing innovative therapeutics targeting viruses, bacteria, fungi, and biofilm formations. Utilizing a unique drug-discovery platform, the company aims to create affordable and effective health solutions to combat infectious diseases and enhance healthspan.

Evimero
Evimero

Evimero is an interdisciplinary company focused on understanding the interactions between microorganisms and human health, agriculture, and the environment, utilizing Systems Biology and AI/ML. Evimero applies molecular principles to infectious disease and microbiome science to improve health outcomes and environmental sustainability through targeted interventions in dysbiotic microbiomes and in people with infectious disorders. Evimero has an infectious disease product pipeline including both prophylactic and diagnostic assets against common causes of Travelers' Diarrhea, including a unique approach to preventing infection with human Norovirus, enterotoxigenic E. coli (ETEC) and others. Evimero's pipeline of drugs targeting human and animal microbiomes includes early-stage assets aimed at generalized microbiome-driven inflammation and gut leak, and specific disease-targeted disorders including Parkinson Disease and Inflammatory Bowel Diseases. Evimero's platform also makes possible a suite of point-of-care diagnostics that can be used for patient cohorting (infectious diseases), risk stratification, and ultimately informing therapeutic decision-making. The nature of Evimero's platform assures a steady stream of novel assets targeting both infectious diseases and chronic disorders with roots in microbiome dysfunction.

NEXT Labs, LLC
NEXT Labs, LLC

NEXT Labs is pioneering the automation and accessibility of next-generation sequencing (NGS) by developing affordable, portable solutions for sample and library preparation. Their mission is to enable sequencing anywhere, by anyone, moving NGS from specialized labs to point-of-need applications. By automating complex sample processing steps, NEXT Labs aims to democratize genomics research and diagnostics, making advanced testing faster, more accessible, and cost-effective for a wide range of applications including infectious disease detection, cancer, and neurodegenerative disease diagnostics.

University of South Carolina
University of South Carolina

The Molinaroli College of Engineering and Computing at the University of South Carolina fosters innovation by preparing engineers and computing professionals to develop new technologies that will improve lives and the world. The college is committed to addressing real-world challenges through education, research, and community engagement.

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