SPOC Proteomics, Inc.
SPOC Biosciences is a deep-tech life sciences company that developed a sensor-integrated proteome-on-chip platform for high-throughput, on-chip cell‑free protein production and real‑time kinetic screening. The platform produces hundreds to thousands of full‑length folded proteins directly on biosensor chips and measures kinetic parameters (ka, kd, KD, t1/2, RU) using surface plasmon resonance (SPR), with planned compatibility with MALDI mass‑spectrometry screening. Offerings include custom chip production, on‑demand kinetic datasets for AI model training, and workflows for antibody/protein affinity ranking, epitope mapping, and vaccine antigen screening.
Industries
N/A
Products
HyperKinetiKx SPR Assay Suite
High‑throughput SPR product suite for preclinical discovery that synthesizes thousands of variants on‑chip to deliver ultra‑high‑resolution kinetic profiles, epitope mapping, polyreactivity scanning, and affinity maturation workflows.
HyperSynaptiKx SPR Assay Suite
SPR workflow suite designed for AI‑driven design–build–test cycles that synthesizes AI‑designed libraries on‑chip to generate large kinetic datasets for model feedback and lead optimization.
HyperKinetiKx SPR Assay Suite
High‑throughput SPR product suite for preclinical discovery that synthesizes thousands of variants on‑chip to deliver ultra‑high‑resolution kinetic profiles, epitope mapping, polyreactivity scanning, and affinity maturation workflows.
HyperSynaptiKx SPR Assay Suite
SPR workflow suite designed for AI‑driven design–build–test cycles that synthesizes AI‑designed libraries on‑chip to generate large kinetic datasets for model feedback and lead optimization.
Services
On‑demand kinetic dataset generation for AI training (ContactIQ)
Custom synthesis of hundreds to thousands of antibody/protein/peptide variants on biosensor chips and generation of high‑resolution kinetic datasets tailored for AI model training and supervised fine‑tuning.
Multiplexed on‑chip library screening and affinity ranking (AffiRank/AffiBoost)
Synthesis and SPR profiling of 192–1,152 variants per chip for affinity ranking, iterative affinity maturation, and residence‑time based lead selection.
Vaccine antigen discovery and immune profiling
Serum/plasma screening against on‑chip pathogen proteomes to identify immunogenic antigens, measure isotypes and kinetics, and support correlates of protection in preclinical/clinical studies.
Catalog and custom biosensor chip production and distribution
Manufacture, storage, and shipment of preconfigured or custom chips containing on‑chip expressed proteins for customer use or in‑house screening.
On‑demand kinetic dataset generation for AI training (ContactIQ)
Custom synthesis of hundreds to thousands of antibody/protein/peptide variants on biosensor chips and generation of high‑resolution kinetic datasets tailored for AI model training and supervised fine‑tuning.
Multiplexed on‑chip library screening and affinity ranking (AffiRank/AffiBoost)
Synthesis and SPR profiling of 192–1,152 variants per chip for affinity ranking, iterative affinity maturation, and residence‑time based lead selection.
Vaccine antigen discovery and immune profiling
Serum/plasma screening against on‑chip pathogen proteomes to identify immunogenic antigens, measure isotypes and kinetics, and support correlates of protection in preclinical/clinical studies.
Catalog and custom biosensor chip production and distribution
Manufacture, storage, and shipment of preconfigured or custom chips containing on‑chip expressed proteins for customer use or in‑house screening.
Expertise Areas
- High‑throughput proteomics
- Cell‑free protein expression
- Surface plasmon resonance kinetic analysis
- On‑chip deep mutational scanning and epitope mapping
Key Technologies
- Cell‑free transcription/translation in nanowells
- On‑chip covalent capture chemistry and fusion‑tag capture
- Surface plasmon resonance (SPR) biosensing
- MALDI‑TOF / TimsTOF mass spectrometry profiling (planned)