Aphios
Aphios is a green biotechnology company focused on developing enabling nanotechnology platforms and enhanced therapeutics for health maintenance, disease prevention, and treatment of various conditions including cancers, infectious diseases, and central nervous system (CNS) disorders. The company emphasizes environmentally-sustainable practices and aims to improve the quality of life through innovative therapies.
Aphios
What We Do
Developing enhanced therapeutics for treating cancers, infectious diseases, and CNS disorders, as well as quality-of-life medicines and research chemicals.
An enhanced ginger product for treating chemotherapy-induced nausea and vomiting, recently completed a successful Phase 2/3 clinical trial.
A non-toxic Vitamin D3 analog for hormone-refractory prostate cancer, designed to have increased antiproliferative effects while reducing systemic toxicity.
A Taxotere® prodrug encapsulated in biodegradable polymer nanospheres to enhance oral bioavailability for chronic chemotherapy.
A combination of a Taxotere® prodrug and monoclonal antibody targeted to treat metastatic cancer.
A nanosomal formulation of paclitaxel for treating Kaposi’s sarcoma and skin cancers.
An enhanced Saw Palmetto botanical drug for treating benign prostatic hyperplasia and male pattern baldness.
An orally bioavailable nanoformulation of betulinic acid for melanoma, designed to improve drug delivery and efficacy.
An orally bioavailable nanoformulation of betulinic acid that works as an HIV maturation inhibitor.
A combination therapy consisting of PKC agonists with or without HDAC inhibitors, designed to reactivate latent HIV reservoirs.
A marine molecule effective against MRSA, VRE, and other Gram-positive microorganisms.
An anti-plaque compound discovered from screening marine microorganisms against microbes responsible for gingivitis.
A therapeutic product under development for Alzheimer's Disease, focusing on activating PKC to ameliorate cognitive impairment.
A novel α-secretase modulator for treating Alzheimer's Disease, designed to enhance neuroprotection and cognitive function.
A Multiple Sclerosis disease-modifying therapeutic that activates the PPARγ pathway expressing both anti-inflammatory and neuroprotective bioactivities.
An oral nanoformulation of Δ9-THC for chemotherapy-induced nausea and vomiting, pain, and cachexia in AIDS and cancer patients.
A nanoencapsulation of insulin in biodegradable polymer nanospheres for oral delivery, aimed at improving bioavailability for diabetics.
An enhanced St. John’s Wort botanical product standardized by hyperforin for use as an alternative to prescription antidepressants.
A stable salt of adhyperforin, an active constituent of St. John’s Wort, known for its antidepressant and anxiolytic properties.
A stable salt of hyperforin, which is the primary active constituent responsible for the antidepressant and anxiolytic properties of St. John’s Wort extracts.
A precursor of betulinic acid, a triterpene found in the bark of the Betula alba (white birch) tree, known for its anti-cancer properties.
A pentacyclic triterpenoid active against melanoma cancer, HIV, malaria, herpesvirus, and leishmaniasis.
A potent Protein Kinase C modulator isolated from the bryozoan Bugula neritina, used in cancer treatment.
A potent Protein Kinase C modulator with anti-tumor properties, isolated from Bugula neritina.
A Protein Kinase C modulator isolated from Bugula neritina, with potential antineoplastic activity.
A potent topoisomerase I inhibitor and anticancer compound isolated from the Chinese Happy Tree, known for its effectiveness against various cancers.
A toxic constituent of Xanthium spp., which is a selective inhibitor of the adenine nucleotide translocator in mitochondria.
An anti-tumor compound isolated from the Yew Tree (Taxus sp.), used in cancer treatment.
An alkaloid isolated from the corn lily (_Veratrum californicum_) that is a Sonic Hedgehog gene pathway antagonist with potential anticancer properties.
A steroidal alkaloid isolated from the corn lily (_Veratrum californicum_) that is a Sonic Hedgehog gene pathway antagonist with potential anticancer properties.
A paclitaxel intermediate isolated from the Yew Tree (_Taxus_ sp.) used in the semi-synthetic manufacturing of paclitaxel.
A paclitaxel intermediate isolated from the Canadian yew tree (_Taxus canadensis_).
The primary active constituent of marijuana (_Cannabis sativa_) responsible for its psychoactive and medicinal properties.
The non-psychoactive precursor of the primary active constituent of marijuana (_Cannabis sativa_).
A triterpenoid saponin isolated from the sea cucumber _Cucumaria frondosa_ with anticancer properties.
A bioactive ingredient of ginger root (_Zingiber officinale_), a medicinal plant having anti-nausea, anti-inflammatory, and anti-carcinogenic properties.
A bioactive ingredient of ginger root (_Zingiber officinale_), known for its medicinal properties.
A bioactive ingredient of ginger root (_Zingiber officinale_), known for its medicinal properties.
The primary active constituent responsible for the antidepressant and anxiolytic properties of St. John’s Wort.
A stable salt of hyperforin, which is the primary active constituent responsible for the antidepressant and anxiolytic properties of St. John’s Wort extracts.