Scarab Genomics LLC.
Provider of engineered reduced-genome Escherichia coli hosts, ancillary expression tools, and a continuous fermentation platform to support high-efficiency production of recombinant proteins and nucleic acids. Offers a catalog of host strains with targeted genetic deletions (e.g., removal of insertion sequences, proteases, toxin-antitoxin pairs, methylases), research-use vaccine carrier proteins, analytical kits, licensing options, and technical support for strain selection and process development.
Industries
Nr. of Employees
small (1-50)
Scarab Genomics LLC.
1202 Ann Street Madison, WI 53713 USA
Patents
Materials and methods for extended continuous flow fermentation of reduced genome bacteria
US-11142745-B2
View Details
Materials and methods for extended continuous flow fermentation of reduced genome bacteria
US-11142745-B2
View DetailsProducts
Catalog of reduced-genome E. coli production strains
A catalog of engineered reduced-genome E. coli strains with variants including recA deletions, low-mutator backgrounds, T7-compatible strains, low-endotoxin modifications, methylation-deficient variants, protease-deletion libraries, toxin-antitoxin deletions and reduced E. coli Nissle 1917 derivatives.
Vaccine carrier proteins for research
Research-grade carrier proteins used in conjugate vaccine research and development, supplied with purification methods described.
Expression vector (pSX2) for host strains
An expression vector product intended to improve cloning and expression of target genes in the company's host strains.
Insertion sequence detection kit
An analytical kit to detect insertion sequence contamination in DNA preparations.
Continuous fermentation platform (C-Flow) - licensing
A process and system for extended continuous fermentation intended to increase efficiency and consistency of biopharmaceutical production; available via licensing.
Catalog of reduced-genome E. coli production strains
A catalog of engineered reduced-genome E. coli strains with variants including recA deletions, low-mutator backgrounds, T7-compatible strains, low-endotoxin modifications, methylation-deficient variants, protease-deletion libraries, toxin-antitoxin deletions and reduced E. coli Nissle 1917 derivatives.
Vaccine carrier proteins for research
Research-grade carrier proteins used in conjugate vaccine research and development, supplied with purification methods described.
Expression vector (pSX2) for host strains
An expression vector product intended to improve cloning and expression of target genes in the company's host strains.
Insertion sequence detection kit
An analytical kit to detect insertion sequence contamination in DNA preparations.
Continuous fermentation platform (C-Flow) - licensing
A process and system for extended continuous fermentation intended to increase efficiency and consistency of biopharmaceutical production; available via licensing.
Services
Commercial licensing of engineered host strains and continuous fermentation process; advisory support on strain selection and expression conditions for specific targets.
Commercial licensing of engineered host strains and continuous fermentation process; advisory support on strain selection and expression conditions for specific targets.
Expertise Areas
- Strain engineering for production hosts
- Bioprocessing and continuous fermentation
- Recombinant protein expression and purification
- Plasmid and nucleic acid production
Key Technologies
- Reduced-genome bacterial host engineering
- Extended continuous fermentation / continuous flow bioprocessing
- Plasmid production and purification
- High-yield dsRNA and small RNA synthesis
News & Updates
Webinar participation announced for May 6, 2025.
Announcement of a laboratory technician position in Madison, WI.
Announcement of a remote digital marketing coordinator role supporting bioinformatics and biotech marketing efforts.
Article describing risks posed by insertion sequence elements in production strains and recommending use of reduced-genome hosts to avoid IS transposition into product DNA.
Case example of rapid development and delivery of antibody expression processes and samples to a contract manufacturer.
Allowance of a US patent covering purification of a vaccine carrier protein.
Webinar participation announced for May 6, 2025.
Announcement of a laboratory technician position in Madison, WI.
Announcement of a remote digital marketing coordinator role supporting bioinformatics and biotech marketing efforts.
Article describing risks posed by insertion sequence elements in production strains and recommending use of reduced-genome hosts to avoid IS transposition into product DNA.
Case example of rapid development and delivery of antibody expression processes and samples to a contract manufacturer.
Allowance of a US patent covering purification of a vaccine carrier protein.