Gearbox Biosciences
Gearbox Biosciences specializes in antibiotic-free protein production using innovative plasmid technology. Their mission is to develop advanced biotechnological solutions for efficient and environmentally friendly protein and plasmid manufacturing, with a focus on regulatory ease and safety.
Industries
Nr. of Employees
small (1-50)
Products
Chromosome-to-plasmid expression platform for antibiotic-free protein production
A production platform where a gene of interest is integrated into the host chromosome during growth and subsequently excised to form a replicating plasmid; designed to enable antibiotic-free, inducer-free, high-expression production in E. coli.
Chromosome-to-plasmid expression platform for antibiotic-free protein production
A production platform where a gene of interest is integrated into the host chromosome during growth and subsequently excised to form a replicating plasmid; designed to enable antibiotic-free, inducer-free, high-expression production in E. coli.
Services
Commercial licensing of the antibiotic-free expression platform for use in external protein or plasmid production workflows.
Joint development projects and partnerships to adapt the platform to specific production needs such as plasmid DNA manufacturing and difficult sequences.
Commercial licensing of the antibiotic-free expression platform for use in external protein or plasmid production workflows.
Joint development projects and partnerships to adapt the platform to specific production needs such as plasmid DNA manufacturing and difficult sequences.
Expertise Areas
- Antibiotic-free recombinant protein production
- Strain engineering and genetic circuit design
- Bioprocess development for high-cell-density cultivation
- Plasmid DNA manufacturing workflows
Key Technologies
- Chromosomal integration with excision-mediated plasmid formation
- oriC excision-based growth arrest
- Temperature-triggered production switching
- Promoter relocation for inducer-free expression
News & Updates
The partnership aims to co-develop technologies set to revolutionize manufacturing of plasmid DNA (pDNA), a critical raw material for advanced medicines, focusing on innovative workflows for antibiotic-free pDNA manufacturing and difficult-to-manufacture sequences.
Gearbox Biosciences secured an applied research grant from EIS | Enterprise Estonia to develop new antibiotic-free technology for plasmid production, adapting their Pop-Out-Plasmid technology for plasmid production.
Gearbox Biosciences received a grant from Enterprise Estonia to support development of a high cell density bioreactor process for POP technology and a deep tech start-up grant for business development and market segment analysis.
The partnership aims to co-develop technologies set to revolutionize manufacturing of plasmid DNA (pDNA), a critical raw material for advanced medicines, focusing on innovative workflows for antibiotic-free pDNA manufacturing and difficult-to-manufacture sequences.
Gearbox Biosciences secured an applied research grant from EIS | Enterprise Estonia to develop new antibiotic-free technology for plasmid production, adapting their Pop-Out-Plasmid technology for plasmid production.
Gearbox Biosciences received a grant from Enterprise Estonia to support development of a high cell density bioreactor process for POP technology and a deep tech start-up grant for business development and market segment analysis.