Gearbox Biosciences
Gearbox Biosciences specializes in antibiotic-free protein production using innovative plasmid technology. Their mission is to develop advanced biotechnological solutions for efficient and environmentally friendly protein and plasmid manufacturing, with a focus on regulatory ease and safety.
Industries
Nr. of Employees
small (1-50)
Products
Chromosome-to-plasmid expression platform for antibiotic-free protein production
A production platform where a gene of interest is integrated into the host chromosome during growth and subsequently excised to form a replicating plasmid; designed to enable antibiotic-free, inducer-free, high-expression production in E. coli.
Chromosome-to-plasmid expression platform for antibiotic-free protein production
A production platform where a gene of interest is integrated into the host chromosome during growth and subsequently excised to form a replicating plasmid; designed to enable antibiotic-free, inducer-free, high-expression production in E. coli.
Services
Licensing of chromosome-to-plasmid expression platform
Commercial licensing of the antibiotic-free expression platform for use in external protein or plasmid production workflows.
Collaborative R&D and partnering
Joint development projects and partnerships to adapt the platform to specific production needs such as plasmid DNA manufacturing and difficult sequences.
Licensing of chromosome-to-plasmid expression platform
Commercial licensing of the antibiotic-free expression platform for use in external protein or plasmid production workflows.
Collaborative R&D and partnering
Joint development projects and partnerships to adapt the platform to specific production needs such as plasmid DNA manufacturing and difficult sequences.
Expertise Areas
- Antibiotic-free recombinant protein production
- Strain engineering and genetic circuit design
- Bioprocess development for high-cell-density cultivation
- Plasmid DNA manufacturing workflows
Key Technologies
- Chromosomal integration with excision-mediated plasmid formation
- oriC excision-based growth arrest
- Temperature-triggered production switching
- Promoter relocation for inducer-free expression