ONSSI
ONSSI Corporation is a university-originated startup venture dedicated to accelerating the research and development of innovative therapeutic drugs for intractable diseases, aiming to deliver these medicines to patients as quickly as possible. Established in 2019 and recognized as an Iwate Medical University-certified venture in August 2023, the company focuses on novel gene therapies and antibody pharmaceuticals, emphasizing partnerships with other companies and universities to bring groundbreaking medicines to patients and their families.
Industries
Products
Viral-vector gene therapy candidate (SOCS3 expression)
Preclinical gene therapy approach using viral vectors to force expression of SOCS3 in tumor cells to inhibit constitutively active STAT3 signaling and produce antitumor effects.
Monoclonal antibody–drug conjugate development targeting tumor-enriched membrane antigen
Preclinical development of monoclonal antibodies linked to cytotoxic drugs directed against cell-surface antigens identified as overexpressed in certain cancers (example target: glypican family member identified by membrane proteomics).
Viral-vector gene therapy candidate (SOCS3 expression)
Preclinical gene therapy approach using viral vectors to force expression of SOCS3 in tumor cells to inhibit constitutively active STAT3 signaling and produce antitumor effects.
Monoclonal antibody–drug conjugate development targeting tumor-enriched membrane antigen
Preclinical development of monoclonal antibodies linked to cytotoxic drugs directed against cell-surface antigens identified as overexpressed in certain cancers (example target: glypican family member identified by membrane proteomics).
Services
Contract proteomics analysis (gel band identification)
In-gel digestion and LC-MS/MS identification of proteins from excised SDS-PAGE or 2D electrophoresis bands submitted by customers; results delivered by email.
Shotgun proteomics contract service
Comprehensive proteome identification workflow including protein extraction, quantification, enzymatic digestion, nanoLC-MS/MS acquisition and data analysis to deliver lists of identified proteins.
Sample-preparation consultation for MS-based proteomics
Advisory service on sample-preparation methods, contamination control, staining protocols and appropriate consumables to optimize mass-spectrometry outcomes.
Contract proteomics analysis (gel band identification)
In-gel digestion and LC-MS/MS identification of proteins from excised SDS-PAGE or 2D electrophoresis bands submitted by customers; results delivered by email.
Shotgun proteomics contract service
Comprehensive proteome identification workflow including protein extraction, quantification, enzymatic digestion, nanoLC-MS/MS acquisition and data analysis to deliver lists of identified proteins.
Sample-preparation consultation for MS-based proteomics
Advisory service on sample-preparation methods, contamination control, staining protocols and appropriate consumables to optimize mass-spectrometry outcomes.
Expertise Areas
- Proteomics analysis and biomarker discovery
- Mass-spectrometry-based analytical services
- Gene therapy development (viral vector-mediated)
- Antibody-drug conjugate discovery and development
Key Technologies
- NanoLC-MS/MS
- High-resolution tandem mass spectrometry
- HPLC for proteomics
- Shotgun (bottom-up) proteomics