Miromatrix Medical
Developer of biologic, transplantable organs using perfusion-based decellularization of porcine organs and subsequent perfusion recellularization with human cells. Focused on engineering kidneys and livers and an extracorporeal bioengineered liver support system. Founded from academic research in 2009, the organization operates preclinical large-animal programs, has completed early clinical work with decellularized matrix products, and holds an extensive global patent portfolio.
Industries
Nr. of Employees
medium (51-250)
Miromatrix Medical
Patents
Methods of recellularizing a tissue or organ for improved transplantability
US-12522802-B2
View DetailsMethods of recellularizing a tissue or organ for improved transplantability
US-12084677-B2
View DetailsMethods of recellularizing a tissue or organ for improved transplantability
US-11414644-B2
View Details
Methods of recellularizing a tissue or organ for improved transplantability
US-12522802-B2
View DetailsMethods of recellularizing a tissue or organ for improved transplantability
US-12084677-B2
View DetailsMethods of recellularizing a tissue or organ for improved transplantability
US-11414644-B2
View DetailsProducts
Bioengineered kidney grafts
Transplantable kidney grafts created by perfusion decellularization of porcine kidneys and perfusion recellularization with human cells for eventual clinical transplantation.
Bioengineered liver grafts
Transplantable liver grafts produced by perfusion decellularization of porcine livers followed by recellularization with hepatocytes and vascular cells; demonstrated sustained perfusion and liver function in large-animal models.
Extracorporeal bioengineered liver support system
An integrated extracorporeal system combining a single-use bioengineered liver graft with an external blood-circuit intended to provide temporary liver support for acute liver failure patients.
Bioengineered kidney grafts
Transplantable kidney grafts created by perfusion decellularization of porcine kidneys and perfusion recellularization with human cells for eventual clinical transplantation.
Bioengineered liver grafts
Transplantable liver grafts produced by perfusion decellularization of porcine livers followed by recellularization with hepatocytes and vascular cells; demonstrated sustained perfusion and liver function in large-animal models.
Extracorporeal bioengineered liver support system
An integrated extracorporeal system combining a single-use bioengineered liver graft with an external blood-circuit intended to provide temporary liver support for acute liver failure patients.
Expertise Areas
- Organ decellularization and scaffold engineering
- Perfusion-based recellularization and organ repopulation
- Bioengineered organ development (kidney and liver focus)
- Preclinical large-animal transplantation studies
Key Technologies
- Perfusion decellularization
- Perfusion recellularization
- Bioreactor-based organ culture
- Vascular re-endothelialization and revascularization
News & Updates
Presentation at a regenerative medicine industry meeting.
Presentation featuring kidney program representatives.
Preclinical study reporting filtration function of decellularized porcine kidney grafts repopulated with human cells in pig models.
Study on manufacturing and functional characterization of bioengineered liver grafts for extracorporeal assistance.
Report of sustained perfusion of re-endothelialized kidney grafts in a human-scale animal model.
Article describing re-endothelialization approaches for decellularized liver scaffolds.
Presentation at a regenerative medicine industry meeting.
Presentation featuring kidney program representatives.
Preclinical study reporting filtration function of decellularized porcine kidney grafts repopulated with human cells in pig models.
Study on manufacturing and functional characterization of bioengineered liver grafts for extracorporeal assistance.
Report of sustained perfusion of re-endothelialized kidney grafts in a human-scale animal model.
Article describing re-endothelialization approaches for decellularized liver scaffolds.