Medical College of Wisconsin

Reports on spin label motion on proteins and lipids, free radical identification and quantitation, plus technology testing with temperature control in the range of 3.8 – 350 K.

Pulse X- and Q-band spectrometer with DEER and saturation recovery capabilities at cryogenic temperatures to measure spin lattice relaxation times and long-range distances between paramagnetic probes in proteins and peptides.

Seahorse analyzers can detect pH changes and oxygen consumption rates for the mitochondrial analysis of eukaryotic cell lines.

Measures mitochondrial respiration, glycolosis, and ATP production in live cells in a 96-well format.

Seahorse analyzers can detect pH changes and oxygen consumption rates for the mitochondrial analysis of eukaryotic cell lines.

Provides analytical services for proteins, peptides, lipids, small molecules, metabolites, and complex glycans.

Non-targeted translational metabolomics mass spectrometry service.

Targeted translational metabolomics mass spectrometry service.

Provides expertise and instrumentation for mass spectrometry analyses, bioenergetic and redox function analyses, pre-clinical imaging, and therapy response.

CAR-T cell manufacturing service run using the Prodigy system.

A liquid chromatograph coupled with UV-Vis absorption and mass spectrometry detection for selective detection and absolute quantification of small molecules.

Enterprise software for clinical trials lifecycle management.

Laboratory specializing in viral vector production and processing.

Biomedical research core facility services providing assessment of mitochondrial and glycolytic function, analysis of cellular metabolites, and study of metabolism-based strategies for cancer treatment.

Laboratory specializing in lymphocyte propagation and cellular services.

Nuclear magnetic resonance facility for molecular and structural analysis.

Laboratory specializing in medical imaging systems and technologies.

Surface plasmon resonance instrument used for measuring protein-ligand binding reactions.

Specialized imaging core services.

Powerful Orbitrap mass spectrometer optimized for lipidomics, metabolomics, and small molecule analysis providing high resolution and fast scanning speeds.

Advanced 3T MRI system utilized for basic sciences, technical development, translational science, and clinical trials.

An integrated data environment comprised of real-world patient data from electronic health record systems and other valuable data resources.

Data entry and result management using LDMS, REDCap, and electronic Case Report Forms.

State-of-the-art imaging mass spectrometer equipped with MALDI-2 technology, enhancing ionization efficiency for lipids and other biomolecules.

Shared research facility providing specialized equipment and services.

The world's first commercially available MR imaging system capable of providing neuroimaging at the point of care, controlled by an Apple iPad.

Provides high-field NMR spectroscopy services for routine 1D and 2D methods, multidimensional, and multinuclear protein NMR spectra.

Translational research unit supporting adult clinical studies.

Preclinical 9.4T MRI system used for small animal and ex vivo imaging.

O-glycan profiling service offered by the Translational Metabolomics Shared Resource.

N-glycan profiling service offered by the Translational Metabolomics Shared Resource.

Targeted MALDI imaging mass spectrometry service.

Provides technology and methods for preclinical bioluminescence, fluorescence, low dose X-ray microCT, Cherenkov Luminescence, NIR, and SWIR imaging.

Non-targeted MALDI imaging mass spectrometry service.

Instruments enabling researchers to interrogate cellular bioenergetics function in real time by simultaneously monitoring oxygen consumption and extracellular acidification rates in a 24- or 96-well plate format.

Translational research unit supporting pediatric studies.

Core laboratory offering advanced microscopic imaging services.

Core laboratories providing biomedical engineering research support.

Core laboratory offering protein chemistry analysis and services.

Preclinical MRI coil for head and body all species.

Preclinical MRI coil for head and body all species.

Provides expertise in biomedical informatics knowledge domains including data warehousing, data modeling, application design and development, recruitment database management, and natural language processing.

Program providing biomolecular engineering research capabilities.

Florence eBinders is a secure, FDA Part 11 and HIPAA-compliant system that replaces paper forms and physical binders, giving research teams an efficient, compliant way to electronically sign, manage, store, and collaborate on study documents and to facilitate remote monitoring.

Access to precision instruments including biosafety cabinets, centrifuges, scales, and pipettes.

Preclinical 4-channel MRI coil for head or subcutaneous tumor, all species.

Targeted clinical lipidomics analysis service.

Preclinical MRI coil for tumor energetics, all species.

High-resolution Orbitrap mass spectrometer designed for advanced multidimensional proteomics research with superior sensitivity and resolution.

Non-targeted clinical lipidomics analysis service.

Coordination and management of over 100 specialized laboratory tests.

Preclinical MRI coil for ex vivo samples.

High-performance mass spectrometer tailored for glycomics research, combining Orbitrap and dual linear ion trap technologies.

Biomarker and pharmacokinetic assay coordination and determinations.

Supports assessment of tumor response to therapy using Precision Imaging Metrics software to track and maintain clinical trial response criteria.

Biobank and analytical tissue core services.

Biochemical assay service for cGMP.

21-channel head/neck coil by GE.

Global health research network and analytics platform enabling clinical researchers to access patient population data and perform feasibility analysis.

Core facility providing flow cytometry analysis and cell sorting services.

Preclinical MRI coil for brain perfusion, rat.

Variable intensity sample processing tailored to study protocols.

Preclinical research services.

24-hour laboratory access for qualified investigators upon consultation.

Quantification service using label-free approach (pricing for 2 samples).

Quality assurance procedures to ensure compliance and sample integrity.

48-channel high-density head coil by GE.

Provides high-field MRI for functional MRI, structural imaging, dynamic contrast imaging, and diffusion imaging along with animal preparation support.

Peripheral blood mononuclear cell (PBMC) extraction services.

Quadrature transmit/receive birdcage head coil.

Glycoproteomics N-glycosylation site occupancy analysis service.

Facility supporting cardiac research studies.

Glycosphingolipid profiling service including GSL preparation.

Compliance support and regulatory guidance for clinical research.

Comprehensive support throughout the lifecycle of scientific projects, from experimental design to data analysis, result interpretation, and mass spectrometry, glycomics, and metagenomics services.

Accrual to Clinical Trials network query tool for exploring and validating clinical study feasibility across CTSA sites.

Core lab providing molecular biology analysis and testing.

Precision liquid handling and aliquot creation for research biospecimens.

10/16-parameter, 8/14-color flow cytometry analyzers used for immunophenotyping.

Navigator tool to assist with IRB processes.

AIR multi-purpose medium coil.

Glycoproteomics N-glycosylation site-mapping service.

Center supporting neuroscience research initiatives.

Instrumentation enabling precise, highly sensitive absolute quantification of nucleic acids using droplet partitioning.

Quantification service using TMT-labeling (pricing for 6-plex: 6 samples).

Preclinical MRI coil for head and neck rat, whole body mouse.

Provides custom peptide synthesis and purification using natural and non-natural amino acids, mass spectrometry characterization, and chromatography equipment.

Coordination of sample testing and transfer with external partner laboratories.

Creation of custom study supply kits for specimen collection.

Laboratory offering bioinformatics and biomathematics consulting and data analysis.

Automated immunoassay analyzer service for high-definition biomarker quantification.

Monitored short-term and long-term sample storage, inventory management, and retrieval.

32-channel head coil manufactured by Nova for high-resolution brain imaging.

Provides metabolic services including ROS measurement, metabolic pathway profiling, oxygen consumption, glycolytic function, membrane potential, and metabolic reprogramming.

De-identification of clinical research samples to protect participant privacy.

Centrifugation services for biological sample processing.

Maintains instruments for isolation and physical characterization of biomolecules and detection of interactions.

A shared resource that leverages data to support innovative translational and population-based research with an emphasis on cancer disparities, providing geospatial mapping, cancer epidemiology, and clinical data access.

High-performance computing cluster supporting advanced research computations.

Coordinates, integrates, streamlines, educates, trains, and supports the use of state-of-the-art data science methods in clinical and translational research.

Flexible multi-purpose anterior array blanket coil utilizing AIR technology.

No-cost service coordinated by the Director of VBRI Shared Resources to assist investigators in referring to VBRI's Shared Resources in grant proposals.

An integrated in vivo imaging system combining Bioluminescence Imaging, Cerenkov Luminescence Imaging, Fluorescence Imaging, and micro-CT for functional and anatomical imaging in small animals.

Dedicated storage facilities for study supplies, reagents, and equipment.

Histology core services for research support.

An in vivo imaging system for preclinical research.

Microplate biochemical assay service for Protein.

16-channel upper extremity hand and wrist coil.

MALDI quick analysis service for samples 21 and above, priced per sample.

Core management software portfolio at MCW providing information and management support.

18-channel lower extremity knee coil.

A 10-parameter, 8-color flow cytometry analyzer that uses a CAR T Cell Express Mode Package design or custom panels.

Daily usage service for Bruker Discovery Optofluidics within the Cell Therapy Shared Resource.

Integrated table coil featuring a 60-channel posterior array with AIR technology.

Protein identification with in-solution digestion.

Center supporting educational and research activities.

Laboratory specializing in nanoengineering research.

Laboratory specializing in hybridoma generation and monoclonal antibody production.

Addition of chemicals or stabilizing agents to research samples.

Specializes in gene silencing and protein expression using lentivirus, retrovirus, and adeno-associated virus systems, including viral vector production, purification, and titration.

Protein identification with in-gel digestion.

Electronic Medical Record Search Engine designed to search clinical text and notes.

Biochemical assay service for cAMP.

High-performance computing grid supporting research computations.

Provides guided access and technical support for comprehensive assessments of energy expenditure and fluid homeostasis in mice and rats.

The Biochemical Core Service Center provides a broad range of assays for biochemical measurements.

Preparation of laboratory requisition forms and necessary setup for study visits.

Controlled incubation of biological samples.

Fully equipped laboratories for biocontainment level 3 preclinical in vivo or in vitro or human in vitro studies.

Houses state-of-the-art microscopic imaging systems including confocal microscopes, laser microdissection systems, and whole slide scanners.

Biochemical assay service for 8-isoprostane.

Preparation of research samples for batch shipping.

Isolation of buffy coat from blood samples.

Separation of plasma, serum, and buffy coat components from whole blood.

Point-of-care urine drug screening service.

Operates and maintains equipment needed for preparation, quantitation and analysis of DNA and RNA, DNA sequencing, real-time PCR amplification, and single-cell sequencing.

Academic departments providing specialized research resources.

Biochemical assay service for Glucose.

Creation of cryogenic-safe labels and barcodes for sample tracking.

A research software engineering tool managed by the CBMI team.

Maintains a suite of instruments and software applications for the analysis and sorting of cells and small particles based on the detection of light scatter and fluorescently labeled markers.

Provides custom services and products related to the production of monoclonal antibodies, maintaining an inventory of established hybridoma cell lines and primary cultures.

Center providing rapid prototyping services for research and development.

Biochemical assay service for 6-keto Prostaglandin.

Biochemical assay service for ANP.

Secure transport and courier services for biospecimens between facilities.

Multi-user server for Jupyter notebooks providing computational environments for data science and research.

Comprehensive statistical consulting covering experimental design, sample size calculation, randomization, data analysis, and clinical trials.

Biochemical assay service for Cholesterol and Triglyceride.

Provides immunoassays, clinical chemistry, and biochemical analyses to meet analytical needs.

Provides access to instrumentation and services that enable ex-vivo analyses of blood coagulation and platelet function, as well as in-vivo evaluation of blood clot formation.

Laboratory for assessing body composition.

Biochemical assay service for BNP.

Biochemical assay service for Calcium.

Provides short read and long read sequencing, single cell sequencing, spatial genomic analysis, and NanoString nCounter applications.

Offers single cell self service access, equipment training, and full service single cell sequencing.

Center dedicated to rehabilitation research, design, and disability solutions.

Real-time cytotoxicity assay service including e-plate.

Provides access to advanced imaging systems including widefield, laser scanning confocal, spinning disk confocal, multiphoton, and super resolution microscopy.

Biochemical assay service for Substance P.

High-performance ion chromatography system for quantitative analysis of anions, cations, and polar analytes.

Facility focusing on neural engineering and neurorehabilitation research.

A compact, benchtop microfluidic cell sorter designed for gentle and rapid sorting of fragile cells.

Biochemical assay service for High-Density Lipoprotein (HDL).

Biochemical assay service for Lactate Dehydrogenase (LDH).

Biochemical assay service for Thiobarbituric Acid Reactive Substances (TBARS).

Handling of high-risk or specialized biological samples under increased safety protocols.

Echocardiography core lab supporting pediatric studies.

Core laboratory providing echocardiography services.

Derives deeper and more physiologically relevant information about your cells with real-time kinetic data, automatically acquiring and analyzing images around the clock.

Flame photometry biochemical assay service for plasma Sodium and Potassium.

Biochemical assay service for Testosterone.

Biochemical assay service for Thromboxane B2.

A research network data component providing expertise in biomedical informatics knowledge domains.

Laboratory providing bionutrition and body composition analysis.

Biochemical assay service for urine creatinine.

Biochemical assay service for Low-Density Lipoprotein (LDL).

Offers researchers a range of specialized equipment including instruments for protein and nucleic acid quantitation, gel imaging, plate reading, and hematology analysis.

Services include tissue fixation, embedding, processing, sectioning, and staining of submitted tissues. Immunohistochemistry is also available.

Research center focusing on human performance and athletics.

Biochemical assay service for plasma creatinine.

Biochemical assay service for Progesterone.

Analytic support service utilizing multicolor quantitative immunofluorescence histo-cytometry for tumor biomarker evaluation.

A novel optofluidic platform that allows one to visualize the phenotype & function of individual cells on a microchip containing 1500 chambers.

Quantitative cell counting services for biological samples.

Core facility for assessing human performance.

A chip-based platform that analyzes single cells for the production of 32 human cytokines or 28 mouse cytokines and effector molecules.

Flame photometry biochemical assay service for Lithium (Li).

Flame photometry biochemical assay service for urine Sodium and Potassium.

Laboratory dedicated to exercise physiology testing.

Laboratory specializing in pediatric neuromotor research.

Sequencing of individual cells to identify rare cell types and separate differential expression of cell clusters from a heterogeneous population.

An electrical impedance-based instrument that facilitates measurement of immune cell cytotoxicity or cell death in a 96-well format.

Biochemical assay service for BUN and Urea.

Analyzes full length paired B-cell or T-cell receptors, surface protein expression, antigen specificity, and gene expression from a single cell.

Biochemical assay service for Microalbumin 580.

Biochemical assay service for Renin Plasma Renin Activity (PRA).

Luminex assay service per run.

State-of-the-art laboratory offering comprehensive services including tissue processing, embedding, sectioning, and staining of biospecimens.

Processing service for blood samples.

Custom near-infrared and short-wave infrared imaging solutions supporting preclinical in vivo studies with deeper tissue penetration and improved resolution.

Features a self-use Fujifilm VisualSonics Vevo 3100 preclinical high frequency/resolution imaging system for in vivo imaging.

Laboratory specializing in ubiquitous computing research.

An operator-assisted high speed cell sorter in both standard and BSL-2+ modes equipped with four adjustable excitation lasers.

Centralized shared facility that systematically collects, stores, and manages biospecimens and associated data for healthcare and disease research.

Utilizes x-ray instruments from Precision capable of irradiating both small animals and cells.

Center dedicated to orthopaedic and rehabilitation engineering.

Web-based software application used to create, submit, track, report and archive applications involving grants, human subjects, animals, and biological materials.

An integrated biobank with an extensive biorepository and robust clinical database capturing biospecimens and clinical data for pancreatic cancer and related diseases.

Offers confocal imaging systems for specialized imaging of neuronal tissue, including the AxL Cleared Tissue Light Sheet Microscope.

Measurement of gene expression changes and splicing patterns to understand cellular and molecular mechanisms underlying disease.

Miscellaneous immunophenotyping array services billed at an hourly rate.

Cohort discovery query tool to find patients using de-identified clinical and demographic data.

Provides state-of-the-art husbandry for axenic (germ-free) and gnotobiotic rodent studies.

CAP accredited laboratory offering routine and specialized histological, immunological, and related services.

Laboratory specializing in biomechanics and motion analysis.

Center specializing in photonics and applied optics.

Extraction of RNA and/or DNA from a variety of sources including blood, saliva, cells, and tissue with low or high-throughput protocols.

A novel surface coil designed to provide high quality and faster MRI scans.

Mapping the entire transcriptome with morphological context to tissue structures using 10x Genomics Visium and CytAssist.

Urine cotinine testing for tobacco exposure screening.

A two-laser, four-color, six-parameter bench-top analyzer used for evaluating surface and intracellular antigen expression, apoptosis detection, and cell-cycle analysis.

Hamilton STAR system for solution making in macromolecular X-ray crystallography.

Provides equipment, computer hardware and software, and service and support necessary for short term or continuous 24-hour-a-day measurement of hemodynamic variables from research animals in their home cages.

Preparation of blood smears for microscopic evaluation.

Provision of dry ice for sample storage and transport needs.

Hemoglobin A1c testing service for long-term blood glucose evaluation.

A 3D cell culture bioreactor designed for growing large organoids and spheroids in a low-shear, in-vivo-like environment.

Our Microscopy Lab offers a broad range of imaging options to faculty and students in the Department of Physiology.

Predictive mapping technology for assessing prostate cancer grade using MRI.

Standard processing of blood samples for downstream research applications.

A microfluidic-based dispenser that integrates with the WOLF G2 to enable precise, high-viability sorting and dispensing of individual cells into multi-well plates.

A versatile transfection system designed for in-vitro, in-vivo, in-ovo, and ex-vivo applications, offering high cell viability for difficult-to-transfect cells.

Urinalysis and testing for urine glucose and protein levels.

Diagnostic radio-HPLC profiling of accumulated fatty acylcarnitines in cultured fibroblasts to screen for all known disorders of b-oxidation.

Fingerstick blood glucose testing service.

MRI-based virtual pathology and histology technology for prostate cancer assessment.

Procurement of fresh tissue samples for research.

Advanced tissue array assembly service.

Fluorescent labeling, capillary electrophoresis system to visualize and assess the size and concentration of nucleic acids.

Phoenix system equipped with a CrysCam for nanoliter crystallization and visualization.

Equipped with up-to-date experimental devices, analysis software, and multifunctional rooms to perform behavioral analysis on rodents.

IATA compliant sample labeling and shipping preparation for ambient, refrigerated, or frozen transport.

Industry standard software used for creating and visualizing chemical structures and reactions.

The Integra VIAFILL instrument is a reagent or cell suspension dispenser into multi-well plates.

Center focused on water quality research and analysis.

Image plate detector system for X-ray diffraction and structural biology research.

A 3D-STED super-resolution imaging system that is capable of STED resolution <100x100x100 nm in 3D and of <30x30 nm in 2D.

NanoString hybridization method to match, barcode, and count miRNA transcripts present in samples.

Preparation of core-based tissue microarrays for high-throughput analyses.

Comprehensive evaluation of DNA base pairs of a sample and variants that arise in the sequence.

Rapid freezing service for tissue preservation.

Cell pellet microarray preparation for research assays.

Urine pregnancy testing service.

Automated, IRB-approved integrated data delivery tool to extract line-item datasets.

Non-invasive assessment service for serial evaluations of cardiac function or real-time monitoring during interventions.

A multi-modal spinning disk confocal system with 3D SMLM and B-TIRF capabilities.

Software engineering tool for de-identifying research images.

Enrichment of ~2% of the human genome focusing on protein-coding regions containing known disease variants.

A benchtop spinning disk confocal microscope that includes 4 laser lines and 3 imaging modalities.

A modern multi-modal spinning disk confocal microscope configured for fast and gentle multi-channel confocal, widefield, and transmitted light imaging.

Prenatal diagnostic radio-HPLC profiling in amniocytes to screen for all known fatty acid oxidation disorders.

A powerful and user-friendly 3D molecular visualization software for protein structures and molecular complexes.

Enzymatic targeting of CpG regions combined with bisulfite conversion to identify methylated bases during next generation sequencing.

Provides access to the PROVEO 8 F42 – Premium Ophthalmic surgical microscope with intraoperative Optical Coherence Tomography (OCT) for precise ocular injections.

A dataset of digitized and annotated prostate cancer histology developed by MCW researchers.

PXA Signal Analyzer covering frequency range from 3 Hz to 44 GHz.

PNA Network Analyzer covering 50 MHz to 40 GHz.

A database curated by the Chemical Abstracts Service that facilitates advanced searching of published research, chemical suppliers, and patent literature.

Digitizing Oscilloscope offering performance up to 40 GSPS.

A targeted laser ablation and photostimulation system used for microscopy applications.

Ultrasound system utilized in procedural training environments.

Neonate high-fidelity patient simulator.

The Payments System allows research coordinators and other support staff to log in and authorize a safe, secure payment for a clinical research participant directly to a MCW Compensation Card.

Portable ultrasound system for clinical simulation.

5-year-old pediatric high-fidelity physiological simulator.

Network analyzer with heads to 240 GHz for high frequency electronic measurements.

A database tool managed by the research software engineering team.

Adult male human patient simulator.

Software for microwave circuit design, simulation, and layout.

Adult high-fidelity patient simulator.

Ultrasound system for vascular access training.

Virtual ultrasound training solution.

Anesthesia machine used for clinical simulation and training.

Portable mechanical ventilator used in emergency simulation scenarios.

Phase noise measurement system used for electronic and frequency analysis.

6-year-old pediatric human patient simulator.

Software to solve electromagnetic problems by finite-element analysis.