Macrotope
Macrotope is a biotechnology company specializing in antigen design and vaccine development. They leverage their MacroAntigen platform to create vaccines and therapeutic antibodies, focusing on infectious diseases like SARS-CoV-2. Their approach emphasizes antigen-centric design, manufacturability, and immunogenicity to develop effective, accessible vaccines and antibody discovery solutions.
Industries
Nr. of Employees
small (1-50)
Products
Platform for tuning antigen conformational dynamics
A technology platform that engineers antigen conformational dynamics to alter immune processing, aiming to increase B-cell engagement and diversity of elicited antibodies.
Vaccine candidates for SARS-CoV-2 and related coronaviruses (preclinical)
Engineered vaccine candidates intended to provide broad protection and sustained immunogenicity against SARS-CoV-2 variants and related coronaviruses, developed with manufacturability considerations.
Platform for tuning antigen conformational dynamics
A technology platform that engineers antigen conformational dynamics to alter immune processing, aiming to increase B-cell engagement and diversity of elicited antibodies.
Vaccine candidates for SARS-CoV-2 and related coronaviruses (preclinical)
Engineered vaccine candidates intended to provide broad protection and sustained immunogenicity against SARS-CoV-2 variants and related coronaviruses, developed with manufacturability considerations.
Services
Antigen design and engineering service
Design and engineering of protein antigen constructs optimized for folding, stability, immunogenicity, and manufacturability.
Scalable antigen production service
High-throughput production of mammalian-expressed protein antigens in multiple formats for research and discovery use.
Antibody discovery support using engineered antigens
Provision of engineered antigens to increase starting antibody library diversity and focus responses on desired epitopes for monoclonal antibody projects.
Preclinical vaccine candidate development
Design, engineering, and preclinical evaluation of vaccine candidates with emphasis on broad protection and manufacturability.
Computational antigen design and bioinformatics consulting
Application and adaptation of computational tools for antigen design, informed by protein structure determination methodologies.
Antigen design and engineering service
Design and engineering of protein antigen constructs optimized for folding, stability, immunogenicity, and manufacturability.
Scalable antigen production service
High-throughput production of mammalian-expressed protein antigens in multiple formats for research and discovery use.
Antibody discovery support using engineered antigens
Provision of engineered antigens to increase starting antibody library diversity and focus responses on desired epitopes for monoclonal antibody projects.
Preclinical vaccine candidate development
Design, engineering, and preclinical evaluation of vaccine candidates with emphasis on broad protection and manufacturability.
Computational antigen design and bioinformatics consulting
Application and adaptation of computational tools for antigen design, informed by protein structure determination methodologies.
Expertise Areas
- Antigen design
- Protein engineering
- Large-scale protein antigen production
- Vaccine candidate development (preclinical)
Key Technologies
- Protein engineering for conformational tuning
- Computational antigen design algorithms
- Bioinformatics for protein structure
- Mammalian expression systems