La Jolla Institute for Allergy & Immunology
Nonprofit research institute focused on human immunology and translational research. Core activities include mechanistic studies of T and B cell responses, epitope identification, antibody discovery and structural analysis, vaccine and adjuvant evaluation, allergy and flavivirus research, single-cell and bulk transcriptomics, shared research cores (flow cytometry, sequencing, microscopy, cryo-EM), database and bioinformatics platform development, and coordination of clinical and observational studies.
Industries
Nr. of Employees
large (251-1000)
La Jolla Institute for Allergy & Immunology
Patents
Human ApoB100 epitopes, methods and uses for modulating inflammatory responses, and treating adverse cardiovascular events, disease and atherosclerosis
US-12448433-B2
View DetailsCompositions and methods for the isolation and/or generation of specific CD4+ and CD8+ T-cell subsets
US-11951128-B2
View Details
Human ApoB100 epitopes, methods and uses for modulating inflammatory responses, and treating adverse cardiovascular events, disease and atherosclerosis
US-12448433-B2
View DetailsCompositions and methods for the isolation and/or generation of specific CD4+ and CD8+ T-cell subsets
US-11951128-B2
View DetailsProducts
Database of Immune Cell Epigenomics (DICE)
Open-access database for immune cell epigenomic and gene-expression data to support analysis of how gene regulation drives immune function.
Immunology and epitope mapping databases
Publicly accessible immunology databases and tools for epitope mapping, epitope analysis and immunogenomics to support target selection and computational analyses.
Allergy and flavivirus research projects
Active research projects in allergen epitope identification, peptide-based immunotherapy concepts, and flavivirus vaccine and pathogenesis studies.
Filovirus Immunogen Display Platform
A display platform using Filovirus GP as an immunogen for targeted vaccine delivery.
Prefusion Stabilized Lymphocytic Choriomeningitis Virus Glycoprotein
An engineered arenaviral immunogen designed by researchers at the La Jolla Institute for Immunology featuring a prefusion stabilized lymphocytic choriomeningitis virus glycoprotein with unique mutations that afford high expression and stability for vaccine and immunotherapeutic development.
Pan-Flavivirus Vaccine that Protects Against Zika Virus and Dengue Virus
A broad-spectrum pan-flavivirus vaccine candidate offering protection against both Zika virus and Dengue virus.
Database of Immune Cell Epigenomics (DICE)
Open-access database for immune cell epigenomic and gene-expression data to support analysis of how gene regulation drives immune function.
Immunology and epitope mapping databases
Publicly accessible immunology databases and tools for epitope mapping, epitope analysis and immunogenomics to support target selection and computational analyses.
Allergy and flavivirus research projects
Active research projects in allergen epitope identification, peptide-based immunotherapy concepts, and flavivirus vaccine and pathogenesis studies.
Filovirus Immunogen Display Platform
A display platform using Filovirus GP as an immunogen for targeted vaccine delivery.
Prefusion Stabilized Lymphocytic Choriomeningitis Virus Glycoprotein
An engineered arenaviral immunogen designed by researchers at the La Jolla Institute for Immunology featuring a prefusion stabilized lymphocytic choriomeningitis virus glycoprotein with unique mutations that afford high expression and stability for vaccine and immunotherapeutic development.
Pan-Flavivirus Vaccine that Protects Against Zika Virus and Dengue Virus
A broad-spectrum pan-flavivirus vaccine candidate offering protection against both Zika virus and Dengue virus.
Services
Next-generation sequencing and sequencing support for genomics and single-cell projects.
Multi-parameter cytometry and cell sorting services with expert consultation.
Tissue processing, histological staining and microscopy imaging support.
Access to cryo-electron microscopy and structural imaging pipelines.
Recruitment, sample collection and longitudinal study support via an institutional clinical investigation center.
Next-generation sequencing and sequencing support for genomics and single-cell projects.
Multi-parameter cytometry and cell sorting services with expert consultation.
Tissue processing, histological staining and microscopy imaging support.
Access to cryo-electron microscopy and structural imaging pipelines.
Recruitment, sample collection and longitudinal study support via an institutional clinical investigation center.
Expertise Areas
- Human immunology and adaptive immune responses
- Epitope identification and immunogen design
- Vaccine research and translational vaccine design
- Adjuvant evaluation in preclinical models
Key Technologies
- Next-generation sequencing (NGS)
- Single-cell RNA sequencing
- Bulk RNA-seq / transcriptomics
- Spatial transcriptomics
News & Updates
Research describing mechanistic studies into how allergy immunotherapies work and efforts to identify allergen peptides that modulate helper T cell responses.
Findings that identify protective T cell responses in children with repeated dengue infections and efforts to inform vaccine strategies.
Research on interactions between Zika and the human immune system to inform defenses against related viral threats.
Up to $49 million in government funding awarded to support multi-institution efforts to develop herpesvirus vaccines.
Award and nearly $450,000 in funding from a private foundation to support a study using deep nasal swabs to study lupus.
Graduate student awarded an NSF Graduate Research Fellowship supporting research on TCR patterns and neoantigen recognition.
Research describing mechanistic studies into how allergy immunotherapies work and efforts to identify allergen peptides that modulate helper T cell responses.
Findings that identify protective T cell responses in children with repeated dengue infections and efforts to inform vaccine strategies.
Research on interactions between Zika and the human immune system to inform defenses against related viral threats.
Up to $49 million in government funding awarded to support multi-institution efforts to develop herpesvirus vaccines.
Award and nearly $450,000 in funding from a private foundation to support a study using deep nasal swabs to study lupus.
Graduate student awarded an NSF Graduate Research Fellowship supporting research on TCR patterns and neoantigen recognition.