Equator Therapeutics
Biotechnology company developing small-molecule drugs that modulate mitochondrial energy production to stimulate thermogenesis as a therapeutic approach for obesity and related metabolic disorders. The team combines mitochondrial electrophysiology, high-throughput screening, medicinal chemistry, computational chemistry, and systems biology to identify and optimize selective activators of mitochondrial heat production and advance preclinical drug candidates.
Industries
Nr. of Employees
small (1-50)
Equator Therapeutics
San Francisco, California, United States
Products
Preclinical mitochondrial thermogenesis activator (development program)
A preclinical small-molecule program to activate mitochondrial thermogenesis as a therapeutic approach for obesity and related metabolic disorders.
Preclinical mitochondrial thermogenesis activator (development program)
A preclinical small-molecule program to activate mitochondrial thermogenesis as a therapeutic approach for obesity and related metabolic disorders.
Services
Discovery and optimization of small molecules that modulate mitochondrial energy production, including target characterization, assay screening, medicinal chemistry, and preclinical candidate selection.
Discovery and optimization of small molecules that modulate mitochondrial energy production, including target characterization, assay screening, medicinal chemistry, and preclinical candidate selection.
Expertise Areas
- Mitochondrial biology and bioenergetics
- Drug discovery for obesity and metabolic disorders
- High-throughput electrophysiological screening
- Medicinal chemistry and lead optimization
Key Technologies
- Mitochondrial electrophysiology (direct electrical recording)
- High-throughput screening (HTS) for bioelectric readouts
- Computational chemistry
- Structural modeling of membrane proteins
News & Updates
Peer-reviewed article describing mechanisms by which mitochondrial uncouplers induce proton leak, relevant to thermogenesis research.
Study describing proton transport function of mitochondrial ADP/ATP carrier, foundational to mitochondrial bioenergetics work.
Research on mechanisms of UCP1-dependent uncoupling in brown adipose tissue mitochondria.
Peer-reviewed article describing mechanisms by which mitochondrial uncouplers induce proton leak, relevant to thermogenesis research.
Study describing proton transport function of mitochondrial ADP/ATP carrier, foundational to mitochondrial bioenergetics work.
Research on mechanisms of UCP1-dependent uncoupling in brown adipose tissue mitochondria.