Butcher Lab
Academic research laboratory at Cornell University investigating mechanobiology and developmental biology of cardiovascular tissues. The group combines experimental, computational, imaging, materials, and biofabrication approaches to study heart and valve morphogenesis, disease mechanisms (including calcification), and regenerative engineering strategies such as 3D bioprinting and bioreactor-based mechanical conditioning.
Industries
Nr. of Employees
small (1-50)
Butcher Lab
304 Weill Hall, Cornell University, Ithaca, NY 14853-7501
Products
Method for specifying and fabricating an object; associated apparatus
Patent covering a method and apparatus related to specifying and fabricating objects; relates to fabrication workflows.
Biomedical implant for use in fluid shear stress environments
Patent describing an implant designed for performance in fluid shear stress environments; relevant to device design and surface strategies for blood-contacting implants.
Prototype 3D-printed anatomically accurate heart valve conduits
Research prototypes of trileaflet valve conduits fabricated using biologically derived, cell-friendly printable hydrogels and human valve interstitial cells; demonstrated in peer-reviewed publications.
Method for specifying and fabricating an object; associated apparatus
Patent covering a method and apparatus related to specifying and fabricating objects; relates to fabrication workflows.
Biomedical implant for use in fluid shear stress environments
Patent describing an implant designed for performance in fluid shear stress environments; relevant to device design and surface strategies for blood-contacting implants.
Prototype 3D-printed anatomically accurate heart valve conduits
Research prototypes of trileaflet valve conduits fabricated using biologically derived, cell-friendly printable hydrogels and human valve interstitial cells; demonstrated in peer-reviewed publications.
Services
Collaborative projects combining developmental biology, engineering, imaging, and clinical translation in cardiovascular research.
Design and prototyping of 3D bioprinting workflows, bioink formulations, and bioreactor conditioning regimens for engineered cardiac and valve tissues.
Dynamic micro-CT imaging pipelines, ultrasound-based deformation analysis, and quantitative image-analysis algorithm development for embryonic and engineered tissues.
Custom 3D co-culture platforms, cyclic-stretch and shear stress assays, and advanced cell-phenotype and calcification models.
Collaborative projects combining developmental biology, engineering, imaging, and clinical translation in cardiovascular research.
Design and prototyping of 3D bioprinting workflows, bioink formulations, and bioreactor conditioning regimens for engineered cardiac and valve tissues.
Dynamic micro-CT imaging pipelines, ultrasound-based deformation analysis, and quantitative image-analysis algorithm development for embryonic and engineered tissues.
Custom 3D co-culture platforms, cyclic-stretch and shear stress assays, and advanced cell-phenotype and calcification models.
Expertise Areas
- Cardiovascular mechanobiology
- Heart valve tissue engineering
- 3D bioprinting and biofabrication
- Multiscale computational modeling of cardiac growth and remodeling
Key Technologies
- Extrusion-based 3D bioprinting
- Photocrosslinkable hydrogel bioinks
- Bioreactor systems for pressure, stretch, and shear conditioning
- Dynamic micro-computed tomography with gating
News & Updates
Peer-reviewed study describing 3D printing of heterogeneous valve conduits using alginate/gelatin hydrogel formulations and cells.
Demonstration of rapid 3D printing approaches for anatomically accurate, mechanically heterogeneous valve scaffolds.
Method for noninvasive, microscopy-guided femtosecond-laser photoablation to create localized cardiac lesions in avian embryos.
Quantitative volumetric analysis of cardiac morphogenesis assessed through micro-computed tomography
Quantitative analysis methods using micro-CT for cardiac morphogenesis studies.
Visualized protocols for isolation and culture of valvular endothelial cells published in a video-methods journal.
Investigation of mechanisms linking endothelial oxidative stress to myofibroblastic activation and valve calcification.
Peer-reviewed study describing 3D printing of heterogeneous valve conduits using alginate/gelatin hydrogel formulations and cells.
Demonstration of rapid 3D printing approaches for anatomically accurate, mechanically heterogeneous valve scaffolds.
Method for noninvasive, microscopy-guided femtosecond-laser photoablation to create localized cardiac lesions in avian embryos.
Quantitative volumetric analysis of cardiac morphogenesis assessed through micro-computed tomography
Quantitative analysis methods using micro-CT for cardiac morphogenesis studies.
Visualized protocols for isolation and culture of valvular endothelial cells published in a video-methods journal.
Investigation of mechanisms linking endothelial oxidative stress to myofibroblastic activation and valve calcification.