Aptus Bioreactors
Aptus Bioreactors is dedicated to improving the prognosis of heart valve diseases by providing innovative bioreactor systems and accessories for creating and testing living, patient-specific tissue engineered heart valves (TEHVs). Their mission is to enable 'One Surgery, for Life' by eliminating hospital costs, risks, and burdens associated with heart valve disease through advanced bioreactor technology and regenerative medicine approaches.
Industries
Nr. of Employees
small (1-50)
Aptus Bioreactors
Products
Platform heart valve bioreactor
Bench-top bioreactor platform that simulates physiological valve conditions for preconditioning scaffolds, pre-clinical tissue development testing, durability and hemodynamic compatibility studies, and device evaluation.
Vascular bioreactor system
Peristaltic pump-driven vascular conditioning system with reservoirs, manifolds, clamps, and compliance chambers to run up to multiple vessels in parallel with tunable pressure and flow parameters.
Rotating cell seeder
Rotational seeding device enabling location-specific cell seeding of valve roots and other scaffolds with control over rotation mode, speed, duration, and sterile gas exchange.
Compliance and burst pressure module
Multi-user module that generates controlled pressures, uses cameras for visualization, and records pressure/time data to compute compliance and burst pressure of tubular tissues.
Quick-connect sterile fluid fittings
Single-piece push-to-lock fittings in biocompatible materials for rapid tubing connection/disconnection in sterile setups; available in a range of sizes and connection types.
MechAnnulus valve mount
Self-adjusting valve holder designed to mount and secure valve roots during seeding and conditioning, compatible with bioprosthetic, mechanical, and tissue valves.
Platform heart valve bioreactor
Bench-top bioreactor platform that simulates physiological valve conditions for preconditioning scaffolds, pre-clinical tissue development testing, durability and hemodynamic compatibility studies, and device evaluation.
Vascular bioreactor system
Peristaltic pump-driven vascular conditioning system with reservoirs, manifolds, clamps, and compliance chambers to run up to multiple vessels in parallel with tunable pressure and flow parameters.
Rotating cell seeder
Rotational seeding device enabling location-specific cell seeding of valve roots and other scaffolds with control over rotation mode, speed, duration, and sterile gas exchange.
Compliance and burst pressure module
Multi-user module that generates controlled pressures, uses cameras for visualization, and records pressure/time data to compute compliance and burst pressure of tubular tissues.
Quick-connect sterile fluid fittings
Single-piece push-to-lock fittings in biocompatible materials for rapid tubing connection/disconnection in sterile setups; available in a range of sizes and connection types.
MechAnnulus valve mount
Self-adjusting valve holder designed to mount and secure valve roots during seeding and conditioning, compatible with bioprosthetic, mechanical, and tissue valves.
Services
Custom design and integration of chambers, fittings, clamps, and experimental protocol adaptations to support specific research workflows and device testing.
Licensing of issued patents and patent applications covering modular bioreactors, compliance chambers, seeding apparatus, fittings, and tissue holders.
Provision of bench-top bioreactor systems (heart valve and vascular platforms), rotating seeding units, compliance/burst modules, mounts, and fittings as configured products for laboratory use.
Custom design and integration of chambers, fittings, clamps, and experimental protocol adaptations to support specific research workflows and device testing.
Licensing of issued patents and patent applications covering modular bioreactors, compliance chambers, seeding apparatus, fittings, and tissue holders.
Provision of bench-top bioreactor systems (heart valve and vascular platforms), rotating seeding units, compliance/burst modules, mounts, and fittings as configured products for laboratory use.
Expertise Areas
- Tissue engineering for heart valves and vascular grafts
- In vitro cardiovascular device testing and conditioning
- Bioreactor design and modular system integration
- Decellularization and scaffold processing
Key Technologies
- Pulsatile flow-loop bioreactors
- Peristaltic pumping and dampening systems
- Compliance chambers and burst-pressure testing
- Rotational cell seeding platforms