AP-SA02 is one example of the novel candidates to emerge from Armata’s robust research and development capabilities. The phages that comprise AP-SA02 were selected with desired attributes for a product candidate targeting S. aureus bacteremia infections. AP-SA02 is comprised of a cocktail of natural lytic S. aureus phages functioning with compatibility (i.e., the phages don’t interfere with one another) and cooperativity (i.e., the phages work together for a better outcome), and further characterized by being highly potent and having a broad host range.
Preclinical highlights of AP-SA02 include:
- Potent antimicrobial activity against approximately 95% of S. aureus clinical isolates tested, including drug-resistant isolates (MRSA: methicillin-resistant S. aureus and VRSA: vancomycin-resistant S. aureus);
- Unique mechanism of action offers synergistic or additive benefit with standard of care antibiotics;
- Component phages are stable and retain infectivity after exposure to relevant biological fluids;
- Penetrates pre-existing S. aureus biofilms;
AP-SA02 is developed as a sterile solution, suitable for delivery by intravenous administration. Clinical trial material of AP-SA02 is manufactured under cGMP at Armata’s production facility in Marina del Rey, California to support the required regulatory filings for clinical entry in the U.S. and ex-U.S.