Principle Diagnostics
Principle Diagnostics is a state-of-the-art clinical and anatomic pathology laboratory founded in 2015, specializing in toxicology, molecular, and genetic testing. Licensed in over 40 states and led by an executive team with over 50 years of cumulative experience, Principle Diagnostics is committed to operational efficiency, adaptive innovation, and personalized service. The company serves a diverse clientele—including individuals, medical facilities, and research organizations—across sectors such as pain management, substance abuse, podiatry, urology, long-term care, memory care, and assisted living. Principle Diagnostics aims to be a leader in diagnostic services by continuously expanding its comprehensive test menu and upholding values of integrity, service, excellence, and innovation. The company is recognized for its strong focus on compliance, financial integrity, and the integration of advanced therapeutic management and antibiotic stewardship programs. Principle Diagnostics is also celebrated for its commitment to ethical principles, teamwork, and inspired people, striving to set an example in the industry for trust, credibility, and patient-focused outcomes. In 2024, Principle Diagnostics celebrated a decade of pioneering advancements in pharmacogenomic (PGx) testing, further cementing its role as an innovation leader in personalized medicine.
Principle Diagnostics
2550 Brodhead Road, Suite 105 Bethlehem, PA 18020
What We Do
Comprehensive toxicology testing using urine or oral fluids, including specimen validity, presumptive, qualitative drug screening, and quantitative drug confirmation.
Genetic testing services covering cancer genetics, cardiac genetics, metabolic genetics, and neuro genetics.
Pharmacogenomic testing to deliver individualized results that improve medication treatment plans, reduce adverse drug side-effects, and provide drug-to-drug interaction information. Principle Diagnostics offers PGx testing for over 100 medications, with non-invasive cheek swab collection and results available within two weeks.
Advanced genetic analysis using next generation sequencing technologies.
Molecular diagnostics for a range of conditions, including UTI, RPP (respiratory pathogen panel), nail, gastro, wound, and COVID-19 testing.
Sensitive molecular testing for SARS-CoV-2 RNA using real-time RT-PCR to detect active infections and help break the transmission chain.
Application Area
Show More (1)Services
Show LessPsychological and Cognitive Health and Performance
Key People
Dr. Allan Zyller
Chairman, Managing Partner
Xuehui Liu
Laboratory Director
News & Updates
Principle Diagnostics holds multiple certifications and accreditations, including CLIA, CMS, NJDOH, FALA, CAP Accreditation, MDOH, and Pennsylvania DOH.
Principle Diagnostics announces a new partnership with Dr. Brad Tice and RxGenomix, offering PharmD overread services for pharmacogenomic laboratory reports.
Spotlight on Dr. Richard Franklin, Medical Director of MVS Wound Care & Hyperbarics, Rosedale, who is Board Certified in General Surgery and specializes in Wound Care and Hyperbaric medicine.
An article discussing the importance of urine specimen validity testing in combating prescription drug misuse and subversion.
Explores how pharmacogenomics can improve patient outcomes and reduce healthcare costs by tailoring medication to individual genetic profiles.
Highlights Principle Diagnostics' long-standing commitment to innovation in pharmacogenomic testing, celebrating 10 years of excellence in PGx and its impact on personalized medicine.