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Principle Diagnostics


Principle Diagnostics is a state-of-the-art clinical and anatomic pathology laboratory founded in 2015, specializing in toxicology, molecular, and genetic testing. Licensed in over 40 states and led by an executive team with over 50 years of cumulative experience, Principle Diagnostics is committed to operational efficiency, adaptive innovation, and personalized service. The company serves a diverse clientele—including individuals, medical facilities, and research organizations—across sectors such as pain management, substance abuse, podiatry, urology, long-term care, memory care, and assisted living. Principle Diagnostics aims to be a leader in diagnostic services by continuously expanding its comprehensive test menu and upholding values of integrity, service, excellence, and innovation. The company is recognized for its strong focus on compliance, financial integrity, and the integration of advanced therapeutic management and antibiotic stewardship programs. Principle Diagnostics is also celebrated for its commitment to ethical principles, teamwork, and inspired people, striving to set an example in the industry for trust, credibility, and patient-focused outcomes. In 2024, Principle Diagnostics celebrated a decade of pioneering advancements in pharmacogenomic (PGx) testing, further cementing its role as an innovation leader in personalized medicine.

Industries

health-diagnostics
medical
wellness

Nr. of Employees

small (1-50)

Principle Diagnostics

Expertise Areas

  • Clinical laboratory diagnostics
  • Toxicology testing and confirmation
  • Molecular diagnostics (real-time PCR/qPCR)
  • Next-generation sequencing and metagenomics
  • Show More (6)

Key Technologies

  • Real-time PCR / qPCR
  • Next-generation sequencing (NGS)
  • Shotgun metagenomics
  • Liquid chromatography–tandem mass spectrometry (LC-MS/MS)
  • Show More (6)

Key People

Gina Mattes

Founder, Chief Executive Officer

LinkedIn

Dr. Allan Zyller

Chairman, Managing Partner

James Rinker

Director of Sales

LinkedIn

Jeanne Lilley

Chief Financial Officer

LinkedIn

Dr. Brad Tice

Pharmacokinetics PharmD Consultant

LinkedIn

James Askey

Director of Molecular Diagnostics

LinkedIn
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News & Updates

Principle Diagnostics holds multiple certifications and accreditations, including CLIA, CMS, NJDOH, FALA, CAP Accreditation, MDOH, and Pennsylvania DOH.

Principle Diagnostics announces a new partnership with Dr. Brad Tice and RxGenomix, offering PharmD overread services for pharmacogenomic laboratory reports.

Spotlight on Dr. Richard Franklin, Medical Director of MVS Wound Care & Hyperbarics, Rosedale, who is Board Certified in General Surgery and specializes in Wound Care and Hyperbaric medicine.

An article discussing the importance of urine specimen validity testing in combating prescription drug misuse and subversion.

Explores how pharmacogenomics can improve patient outcomes and reduce healthcare costs by tailoring medication to individual genetic profiles.

Highlights Principle Diagnostics' long-standing commitment to innovation in pharmacogenomic testing, celebrating 10 years of excellence in PGx and its impact on personalized medicine.

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