Twist Bioscience
Twist Bioscience is a biotechnology company that develops and manufactures synthetic DNA and related products using a proprietary silicon platform. The company's mission is to enable researchers and companies to accelerate scientific discovery and innovation across various fields including healthcare, agriculture, data storage, and environmental sustainability. Twist Bioscience is committed to responsible research, biosecurity, and sustainability, providing high-quality synthetic DNA while adhering to strict biosecurity protocols and promoting environmentally friendly practices. The company actively promotes diversity and inclusion within its workforce and supports responsible use of synthetic biology through comprehensive biosecurity programs. It continuously innovates in DNA synthesis technology, enabling high-throughput, accurate, and scalable production of synthetic DNA, oligonucleotides, and complex gene libraries. Twist Bioscience's platform supports a wide range of applications including gene synthesis, library construction, antibody discovery, protein engineering, and viral research, with a focus on sustainability and reducing environmental impact. The company collaborates with academic, government, and industry partners to advance synthetic biology and biosecurity, and is involved in efforts to develop safer, greener production methods for chemicals and pharmaceuticals using synthetic biology. Twist Bioscience's leadership includes CEO Emily Leproust, COO Bill Banyai, and CTO Bill Peck. The company is headquartered at 681 Gateway Blvd, South San Francisco, CA 94080.
Industries
Nr. of Employees
large (251-1000)
Twist Bioscience
San Francisco, California, United States, North America
Products
Sequence-verified clonal genes (expedited delivery)
Clonal gene constructs produced from user-provided sequences with NGS verification of sequence fidelity and options for delivery cloned into customer-specified vectors with expedited turnaround.
Oligo pools and multiplexed gene fragment pools
High-complexity oligonucleotide pools and multiplexed double-stranded gene fragment pools for CRISPR screens, functional genomics, and library-based assays, with options for cloned pool delivery.
Custom and fixed NGS target enrichment panels
Pre-designed fixed panels and fully custom target enrichment solutions for targeted NGS applications (exome, mitochondrial, viral research, genotyping), manufactured with probe balancing and enrichment chemistries.
Synthetic DNA and RNA controls / reference standards
Synthetic control materials and reference standards for liquid biopsy, infectious-disease assay development and validation, offered in standardized, non-infectious formats for NAAT and sequencing workflows.
Antibody discovery platforms and library products
Products to support antibody discovery workflows including phage-display libraries, pre-designed VHH/camelid libraries, and tools to enable hybrid discovery approaches (phage, in vivo, single-B cell) integrated with computational design.
Sequence-verified clonal genes (expedited delivery)
Clonal gene constructs produced from user-provided sequences with NGS verification of sequence fidelity and options for delivery cloned into customer-specified vectors with expedited turnaround.
Oligo pools and multiplexed gene fragment pools
High-complexity oligonucleotide pools and multiplexed double-stranded gene fragment pools for CRISPR screens, functional genomics, and library-based assays, with options for cloned pool delivery.
Custom and fixed NGS target enrichment panels
Pre-designed fixed panels and fully custom target enrichment solutions for targeted NGS applications (exome, mitochondrial, viral research, genotyping), manufactured with probe balancing and enrichment chemistries.
Synthetic DNA and RNA controls / reference standards
Synthetic control materials and reference standards for liquid biopsy, infectious-disease assay development and validation, offered in standardized, non-infectious formats for NAAT and sequencing workflows.
Antibody discovery platforms and library products
Products to support antibody discovery workflows including phage-display libraries, pre-designed VHH/camelid libraries, and tools to enable hybrid discovery approaches (phage, in vivo, single-B cell) integrated with computational design.
Services
Custom target enrichment panel design and consulting
Consultative design service including needs assessment, bioinformatics probe design, draft review, iterative optimization, pilot testing, and full-scale synthesis of custom NGS panels.
Antibody discovery and engineering services
Integrated discovery services spanning in vivo (hybridoma, single-B cell), in vitro (display libraries), and in silico (ML-assisted) modalities, with downstream expression and characterization workflows.
Technical support and application scientist consultation
Remote and collaborative support from application scientists for panel design, probe selection, library prep optimization, and experimental workflows.
Multiplexed gene fragment (MGF) design and synthesis service
Design, pooled synthesis, and delivery of double-stranded gene fragments (up to ~500 nt) in scalable pool sizes for functional genomics, promoter/enhancer studies, multi-gRNA arrays, and ML/AI validation.
Cloning and high-throughput library assembly
End-to-end cloning and assembly of oligo pools, MGFs, and variant libraries into vectors or screening-ready formats to reduce customer cloning burden and accelerate screening workflows.
Custom target enrichment panel design and consulting
Consultative design service including needs assessment, bioinformatics probe design, draft review, iterative optimization, pilot testing, and full-scale synthesis of custom NGS panels.
Antibody discovery and engineering services
Integrated discovery services spanning in vivo (hybridoma, single-B cell), in vitro (display libraries), and in silico (ML-assisted) modalities, with downstream expression and characterization workflows.
Technical support and application scientist consultation
Remote and collaborative support from application scientists for panel design, probe selection, library prep optimization, and experimental workflows.
Multiplexed gene fragment (MGF) design and synthesis service
Design, pooled synthesis, and delivery of double-stranded gene fragments (up to ~500 nt) in scalable pool sizes for functional genomics, promoter/enhancer studies, multi-gRNA arrays, and ML/AI validation.
Cloning and high-throughput library assembly
End-to-end cloning and assembly of oligo pools, MGFs, and variant libraries into vectors or screening-ready formats to reduce customer cloning burden and accelerate screening workflows.
Expertise Areas
- Synthetic DNA manufacturing
- NGS target enrichment and library preparation
- Custom panel design and bioinformatics
- High-complexity oligo pools and variant library generation
Key Technologies
- Silicon-based DNA synthesis
- Multiplexed gene fragments (MGFs)
- Next-generation sequencing (NGS) target enrichment
- Oligonucleotide pool synthesis