Telesis Bio


Developer of automated benchtop synthetic-biology platforms, reagent kits, and contract biofoundry services for on-demand DNA and RNA design, assembly, amplification, and library construction. Offers custom synthesis and hierarchical assembly of full-length synthetic genomes and variant libraries, small-scale in vitro-transcribed (IVT) mRNA production for iterative screening, synthetic RNA controls for diagnostic validation, and a secure web portal for sequence submission and order management to support vaccine, therapeutic, and diagnostic research workflows.

Industries

Bioinformatics
Biotechnology
Health Care
Biotechnology Research

Nr. of Employees

small (1-50)

Telesis Bio

San Diego, California, United States


Patents

Genetically engineered Vibrio sp. and uses thereof

US-12686871-B2

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Digital to biological converter

US-12589396-B2

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Methods for in vitro joining and combinatorial assembly of nucleic acid molecules

US-12371724-B2

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Genetically engineered Vibrio sp. and uses thereof

US-12331326-B2

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Demand synthesis of polynucleotide sequences

US-12065684-B2

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Methods for assembling nucleic acids

US-12018316-B2

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Products

Automated benchtop synthetic-biology workstation (DNA/RNA assembly)

Benchtop instrument for automated design-build-amplify workflows producing DNA fragments, cloned constructs, and RNA constructs for in-lab on-demand synthesis and assembly.

Reagent kits for assembly, cloning, amplification, and mRNA workflows

Bench-level reagent kits and documented protocols supporting gene synthesis, cloning, DNA amplification, library construction, and IVT mRNA synthesis.

Synthetic RNA controls for diagnostic assay validation

Defined synthetic RNA materials for assay verification and validation to enable testing workflows without handling live virus.

Full-length and variant synthetic genomes

Commercially available full-length synthetic genomes and variant constructs delivered with specification sheets for research use.

BioXp® DNA Cloning and Amplification Kit

Specification sheet for the BioXp mRNA synthesis kit containing all Gibson Assembly and other reagents necessary to synthesize at least 5 micrograms of capped and tailed synthetic mRNA using de novo synthesized, error-corrected gene fragment.

BioXp

The world’s only fully automated benchtop instrument enabling numerous synthetic biology workflows by providing a turn-key, end-to-end solution for generating synthetic mRNA and DNA.

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Services

Custom design and manufacture of DNA parts, gene fragments, clones, and RNA constructs delivered as standalone products or as part of contracted biofoundry work; includes small-scale IVT mRNA production for candidate screening.

Design and automated construction of targeted variant libraries and cloning into expression vectors to support protein, antibody, and antigen discovery and optimization.

Provision and modification of full-length synthetic viral genomes and variant constructs with accompanying specification documentation for research applications.

Provision of laboratory execution, technical staff support, storage, and shipping services for customers lacking on-site laboratory capacity.

Expertise Areas

  • On-demand DNA and RNA synthesis
  • Full-length synthetic genome design and assembly
  • Variant and expression library construction for protein and antibody engineering
  • mRNA-based therapeutics and vaccine scaffold production
  • Show More (5)

Key Technologies

  • Automated benchtop synthesis platforms
  • Enzymatic isothermal DNA assembly
  • Cell-free DNA amplification methods
  • In vitro transcription (IVT) for mRNA production
  • Show More (5)

News & Updates

Announcement of a licensing agreement for adoption of a rapid on-site DNA and gene synthesis platform to support therapeutic discovery.

Recorded webinar describing on-demand synthesis and hierarchical assembly of a full-length synthetic SARS-CoV-2 genome using an automated assembly and cloning instrument.

Application note describing design and synthesis of SARS-CoV-2 genome parts and assembly of full-length genomes; describes capacity to synthesize multiple variant genome parts in a single overnight run.

Case study describing how automated synthesis streamlined construction of nanobody variant libraries for vaccine development and shortened build timelines compared to manual cloning.

Case study showing that automating antibody construct build workflows increased pipeline throughput and reduced cycle times for a biopharmaceutical customer.

Case study describing how an agricultural biotech company used automated library synthesis and contracted services to accelerate enzyme engineering and test more complex variant designs in shorter timeframes.


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