Terra Bioforge
Terra Bioforge is a leading synthetic biology company focused on accelerating the discovery and production of microbial natural products. They leverage proprietary tools, genomics, metabolomics, and data science to create efficient microbial factories for applications in agriculture, pharmaceuticals, and biotech industries. Their mission is to transform natural product development by providing faster, more cost-effective solutions for manufacturing and discovery.
Industries
Nr. of Employees
small (1-50)
Products
Synthetic Biology Platform
A platform for manufacturing and discovering microbial natural products using data science, genomics, metabolomics, and synthetic biology tools.
Pathway Identification
Uses bioinformatics, metabolomics, and machine learning to identify and link microbial metabolites with their biosynthetic pathways.
Pathway Engineering
Involves capturing, manipulating, and screening Biosynthetic Gene Clusters (BGCs) for natural product development.
Heterologous Expression
Scale-up of natural products in optimized hosts like Aspergillus, Streptomyces, Bacillus.
Fungal Metabologenomics
Identifies, clones, and expresses natural products from fungi, leveraging the kingdom's novel chemistry.
BIGDNA Soil Metagenomic Libraries
Metagenomic libraries with 100 kb inserts for capturing full-length pathways, sourced from diverse ecologies.
Synthetic Biology Platform
A platform for manufacturing and discovering microbial natural products using data science, genomics, metabolomics, and synthetic biology tools.
Pathway Identification
Uses bioinformatics, metabolomics, and machine learning to identify and link microbial metabolites with their biosynthetic pathways.
Pathway Engineering
Involves capturing, manipulating, and screening Biosynthetic Gene Clusters (BGCs) for natural product development.
Heterologous Expression
Scale-up of natural products in optimized hosts like Aspergillus, Streptomyces, Bacillus.
Fungal Metabologenomics
Identifies, clones, and expresses natural products from fungi, leveraging the kingdom's novel chemistry.
BIGDNA Soil Metagenomic Libraries
Metagenomic libraries with 100 kb inserts for capturing full-length pathways, sourced from diverse ecologies.
Services
Pathway identification (bioinformatics, metabolomics, ML)
Computational and analytical workflows to identify and link microbial metabolites with their biosynthetic gene clusters using metabolomics, genomics, and machine learning.
Pathway engineering (capture, manipulation, screening of intact BGCs)
Laboratory services to capture intact biosynthetic gene clusters from genomic or metagenomic DNA and to perform DNA-level manipulation and refactoring to enable heterologous expression and optimization.
Heterologous expression and scale-up in engineered hosts
Expression of cloned BGCs in optimized engineered microbial hosts (multiple chassis genera) to screen for product formation and to increase production titers for downstream development.
Fungal metabologenomics and targeted natural product discovery
Integrated fungal-focused metabologenomics platform to chemically annotate fungal genomes with detected metabolites and to prioritize, clone, and express fungal natural product pathways.
Pathway identification (bioinformatics, metabolomics, ML)
Computational and analytical workflows to identify and link microbial metabolites with their biosynthetic gene clusters using metabolomics, genomics, and machine learning.
Pathway engineering (capture, manipulation, screening of intact BGCs)
Laboratory services to capture intact biosynthetic gene clusters from genomic or metagenomic DNA and to perform DNA-level manipulation and refactoring to enable heterologous expression and optimization.
Heterologous expression and scale-up in engineered hosts
Expression of cloned BGCs in optimized engineered microbial hosts (multiple chassis genera) to screen for product formation and to increase production titers for downstream development.
Fungal metabologenomics and targeted natural product discovery
Integrated fungal-focused metabologenomics platform to chemically annotate fungal genomes with detected metabolites and to prioritize, clone, and express fungal natural product pathways.
Expertise Areas
- Natural product discovery
- Biosynthetic gene cluster cloning and engineering
- Fungal strain engineering and fungal metabologenomics
- Heterologous expression and chassis development
Key Technologies
- Biosynthetic gene cluster (BGC) cloning (large-insert capture)
- Filamentous fungal genome engineering
- Inducible expression vectors and dual-promoter activation
- BGC refactoring (multiplexed, marker-free)