Syngulon


Syngulon is a synthetic biology startup developing original genetic technologies using bacteriocins to improve microbial fermentation. Their mission is to provide genetic technologies that make microbial strains involved in industrial processes safer and more efficient, focusing on antibiotic-free selection and contamination prevention in biotechnological applications.

Industries

biotechnology
information-technology-dbca

Nr. of Employees

small (1-50)

Syngulon

Avenue Georges Lemaître 19, B-6041 CHARLEROI, Belgium


Patents

Controlled growth of microorganisms

US-12297422-B2

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Peptides for inducing bacteriocin synthesis and methods to identify and/or select and/or optimize the same

US-12234299-B2

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Methods and compositions for making bacteriocins and antimicrobial peptides

US-12195780-B2

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Engineering antimicrobial peptides

US-12173343-B2

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Fermentation process

US-11932672-B2

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Methods and compositions for making bacteriocins and antimicrobial peptides

US-11492651-B2

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Products

Bacteriocin gene library (PARAGEN collection)

A curated DNA library of natural and synthetic bacteriocin genetic elements organized for industrial application; supports rapid synthesis, testing and combination use to shape microbial communities.

Antibiotic-free selection system for E. coli fermentation (plasmid-based)

A plasmid-based bacteriocin/immunity selection system for recombinant protein and plasmid DNA production in E. coli that avoids antibiotic resistance markers and reports increased plasmid stability and product yield.


Services

Design and provision of bacteriocins or bacteriocin combinations tailored to specific contaminant profiles or production strain requirements; includes metagenomic-informed selection.

Non-exclusive licensing of issued patents and patent applications covering bacteriocin/immunity selection circuits and engineered antimicrobial peptides for industrial use.

Collaborative research programs with academic and industrial partners to discover, optimize and scale bacteriocin-based solutions for specific applications.

Computational modelling services to predict the dynamics of microbial communities and the impact of bacteriocin interventions to inform design and deployment strategies.

Expertise Areas

  • Antibiotic-free selection systems for biomanufacturing
  • Bacteriocin discovery, engineering and library development
  • Recombinant protein and plasmid DNA production workflows
  • Microbial fermentation scale-up and bioprocess development
  • Show More (6)

Key Technologies

  • Bacteriocin-based selection systems
  • Plasmid-based antibiotic-free selection
  • Synthetic biology for peptide design and engineering
  • Cell-free protein/peptide synthesis
  • Show More (6)

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