Signature Science LLC
Signature Science, LLC is a scientific services firm offering physical, life, forensic, and data science-related technical solutions and technologies through research and development, test and evaluation; laboratory operations; and systems design, integration and production. The company serves government and commercial clients with a wide array of technical offerings that combine scientific rigor with proven quality assurance, focusing on national security, public safety, health security, and biosecurity. The company actively develops and provides biosecurity sequence screening solutions, including SeqScreen, which employs machine learning and bioinformatics tools to identify sequences of concern, pathogenicity, and biosecurity risks in genetic data. Signature Science also offers training courses, workshops, and case studies to educate and collaborate with the bioengineering community on biosecurity best practices, regulations, and software applications.
Industries
Nr. of Employees
medium (51-250)
Signature Science LLC
8501 North Mopac Expressway, Suite 100, Austin, TX 78759
Patents
Products
Open-source sequence screening software and curated databases
An open-source pipeline for screening nucleotide and protein sequences with configurable sensitivity/speed modes and long-read support, producing annotated outputs and structured reports that integrate curated functional labels.
Laboratory proficiency testing products and schemes
Proficiency testing materials and programs to assess laboratory performance and support quality assurance across forensic and analytical workflows.
Sampling and sample-preparation hardware
Engineered sampling modules and sample-preparation components for environmental and forensic collection, including aerosol and vapor modules, swab containment canisters, mixing chambers, and thermal desorption assemblies.
Open-source sequence screening software and curated databases
An open-source pipeline for screening nucleotide and protein sequences with configurable sensitivity/speed modes and long-read support, producing annotated outputs and structured reports that integrate curated functional labels.
Laboratory proficiency testing products and schemes
Proficiency testing materials and programs to assess laboratory performance and support quality assurance across forensic and analytical workflows.
Sampling and sample-preparation hardware
Engineered sampling modules and sample-preparation components for environmental and forensic collection, including aerosol and vapor modules, swab containment canisters, mixing chambers, and thermal desorption assemblies.
Services
Forensic DNA extraction, short- and long-read sequencing, SNP and MPS analysis, casework reporting, and expert witness support operating under accredited laboratory quality systems.
Sequence screening services, third‑party tool testing and benchmarking, creation of custom evaluation datasets, and consulting to implement screening frameworks and customer verification processes.
End-to-end sample processing, unbiased genome sequencing, metagenomic and metatranscriptomic analysis, taxonomic and functional profiling, visualization, and benchmarking.
Design and delivery of QA programs, proficiency testing materials and schemes, method validation support, and laboratory quality audits for sampling and analysis operations.
Operational training, realistic exercises for CBRNE response, development of collection and detection protocols, and testing/evaluation of detection methods.
Public and customized training on sequence screening, interpretation of screening outputs, practical use of open-source screening tools, and case-study exercises for workforce development.
Forensic DNA extraction, short- and long-read sequencing, SNP and MPS analysis, casework reporting, and expert witness support operating under accredited laboratory quality systems.
Sequence screening services, third‑party tool testing and benchmarking, creation of custom evaluation datasets, and consulting to implement screening frameworks and customer verification processes.
End-to-end sample processing, unbiased genome sequencing, metagenomic and metatranscriptomic analysis, taxonomic and functional profiling, visualization, and benchmarking.
Design and delivery of QA programs, proficiency testing materials and schemes, method validation support, and laboratory quality audits for sampling and analysis operations.
Operational training, realistic exercises for CBRNE response, development of collection and detection protocols, and testing/evaluation of detection methods.
Public and customized training on sequence screening, interpretation of screening outputs, practical use of open-source screening tools, and case-study exercises for workforce development.
Expertise Areas
- Forensic DNA analysis and complex mixture interpretation
- Functional sequence screening and biosecurity review
- Metagenomic and microbiome sequencing analysis
- CBRNE sampling, detection, and analytical method development
Key Technologies
- Short-read and long-read sequencing
- Open-source sequence functional screening pipelines
- Per-read sensitive alignment (nucleotide and amino-acid space)
- Ensemble machine learning for functional annotation
News & Updates
Signature Science conducted a training course on biosecurity sequence screening, educating participants on SeqScreen software and biosecurity regulations.
Signature Science presented case studies and workshops demonstrating the application of SeqScreen in real-world biosecurity scenarios.
Signature Science published research and updates on SeqScreen, including machine learning models, functional annotations, and new modes such as ONT.
Signature Science participated in conferences discussing biosecurity challenges, regulations, and the role of computational tools like SeqScreen.
An overview of SeqScreen's capabilities, machine learning models, and applications in biosecurity risk assessment.
Details on Signature Science's training courses aimed at educating bioengineers on biosecurity regulations and software tools.
Signature Science conducted a training course on biosecurity sequence screening, educating participants on SeqScreen software and biosecurity regulations.
Signature Science presented case studies and workshops demonstrating the application of SeqScreen in real-world biosecurity scenarios.
Signature Science published research and updates on SeqScreen, including machine learning models, functional annotations, and new modes such as ONT.
Signature Science participated in conferences discussing biosecurity challenges, regulations, and the role of computational tools like SeqScreen.
An overview of SeqScreen's capabilities, machine learning models, and applications in biosecurity risk assessment.
Details on Signature Science's training courses aimed at educating bioengineers on biosecurity regulations and software tools.