MedChem Partners
MedChem Partners is a specialty research and discovery organization based in Lexington, MA, providing comprehensive chemistry support to early and mid-stage drug discovery programs. Since 2006, they have helped numerous companies with high-risk projects, offering quick turnaround and services that mirror internal resources in quality, speed, and responsiveness. Their expertise spans medicinal chemistry, custom synthesis, analytical support, specialty chemistry, expert witness services, and strategic collaborations, aiming to enable better science through innovation.
Industries
Nr. of Employees
small (1-50)
MedChem Partners
Lexington, Massachusetts, United States, North America
Products
Stable-isotope labeled reference standards
Milligram to gram quantities of stable-isotope labeled compounds (2H, 13C, 18O, 15N) prepared as internal standards or reference materials for bioanalytical assays.
Nitric oxide donor compounds and controlled-release formulations
Novel classes of compounds designed to sequester and release nitric oxide in a controlled manner and delivery formats (examples: gels, inhaled analogues) intended for localized therapeutic NO delivery; associated patent filings noted.
Stable-isotope labeled reference standards
Milligram to gram quantities of stable-isotope labeled compounds (2H, 13C, 18O, 15N) prepared as internal standards or reference materials for bioanalytical assays.
Nitric oxide donor compounds and controlled-release formulations
Novel classes of compounds designed to sequester and release nitric oxide in a controlled manner and delivery formats (examples: gels, inhaled analogues) intended for localized therapeutic NO delivery; associated patent filings noted.
Services
Hands-on medicinal chemistry, SAR design, library synthesis, route finding and custom small-molecule synthesis across discovery and lead-optimization stages.
Centralized compound storage, inventory management, sampling, labeling, repackaging and shipping with temperature-controlled and inert-atmosphere options.
Analytical testing packages (HPLC, LC–MS, NMR, IR, MALDI, Karl Fischer, elemental, DLS, zeta potential) and expedited data packages for CoA preparation.
Discovery-stage pre-formulation to address solubility and stability issues, including co-solvents, excipients, pH control, salt selection, lipid formulations, hydrogels and pro-drug strategies.
Project viability assessment, screening strategy establishment, library selection, hit validation, structure-guided design advice, and program initiation documentation for fundraising and due diligence.
Short- or longer-term access to fully stocked lab benches, hoods, common instruments, consumables and administrative support to accelerate start-up activities.
Hands-on medicinal chemistry, SAR design, library synthesis, route finding and custom small-molecule synthesis across discovery and lead-optimization stages.
Centralized compound storage, inventory management, sampling, labeling, repackaging and shipping with temperature-controlled and inert-atmosphere options.
Analytical testing packages (HPLC, LC–MS, NMR, IR, MALDI, Karl Fischer, elemental, DLS, zeta potential) and expedited data packages for CoA preparation.
Discovery-stage pre-formulation to address solubility and stability issues, including co-solvents, excipients, pH control, salt selection, lipid formulations, hydrogels and pro-drug strategies.
Project viability assessment, screening strategy establishment, library selection, hit validation, structure-guided design advice, and program initiation documentation for fundraising and due diligence.
Short- or longer-term access to fully stocked lab benches, hoods, common instruments, consumables and administrative support to accelerate start-up activities.
Expertise Areas
- Medicinal chemistry
- Custom synthesis and scale-up
- Compound management and logistics
- Analytical characterization and QC
Key Technologies
- Nuclear magnetic resonance (NMR) spectroscopy
- Liquid chromatography–mass spectrometry (LC–MS)
- High-performance liquid chromatography (HPLC)
- Automated flash chromatography
News & Updates
Research on nitric oxide donors to enhance wound healing, presented at West Virginia University.
Supported a symposium on translational research and emerging trends in Boston.
Patent for nitric oxide delivery technology issued by USPTO.
Supported a symposium on drug metabolism research in Waltham, MA.
Patent for methods of protection and delivery of aminothiols.
Presented research on nitric oxide compounds for diabetic wound treatment, awarded first place.
Research on nitric oxide donors to enhance wound healing, presented at West Virginia University.
Supported a symposium on translational research and emerging trends in Boston.
Patent for nitric oxide delivery technology issued by USPTO.
Supported a symposium on drug metabolism research in Waltham, MA.
Patent for methods of protection and delivery of aminothiols.
Presented research on nitric oxide compounds for diabetic wound treatment, awarded first place.