InvivoSciences, Inc.
InvivoSciences is a precision medicine company dedicated to developing cost-effective, safe, and effective treatments for inherited heart failure. They utilize next-generation, patient-derived, gene-edited human samples, including automated, scalable 3D engineered micro-human heart tissue platforms, integrating cell & tissue handling automation, tissue phenotyping assays, AI, and human organ/tissue data to accelerate drug discovery and development. Their technology aims to personalize treatment, reduce clinical trial costs, and improve success rates in drug approvals, especially for cardiac conditions.
Industries
Nr. of Employees
small (1-50)
InvivoSciences, Inc.
Madison, Wisconsin, United States, North America
Products
Periodic waveform high-throughput cardiac waveform analyzer
High-throughput analyzer for periodic waveforms used to measure cardiac action potentials, intracellular calcium transients, and force of contraction in tissue or cell-based assays.
Automated cell and tissue culture robot (automation platform)
Automated platform for iPSC maintenance, differentiation-screening, gentle medium handling, passaging without centrifugation, and scale-up of cell production.
Automated force-detection assay system for 3D tissues
Assay system that measures cellular contractility and extracellular matrix stiffness of engineered 3D tissue constructs with single- and multi-probe configurations.
In-house ultra-rapid plate-reader assay implementation
Deployment of ultra-rapid plate-reader instrumentation to perform fluorescent and luminescent assays across entire 96/384-well plates with electrical stimulation for high-throughput phenotyping.
Periodic waveform high-throughput cardiac waveform analyzer
High-throughput analyzer for periodic waveforms used to measure cardiac action potentials, intracellular calcium transients, and force of contraction in tissue or cell-based assays.
Automated cell and tissue culture robot (automation platform)
Automated platform for iPSC maintenance, differentiation-screening, gentle medium handling, passaging without centrifugation, and scale-up of cell production.
Automated force-detection assay system for 3D tissues
Assay system that measures cellular contractility and extracellular matrix stiffness of engineered 3D tissue constructs with single- and multi-probe configurations.
In-house ultra-rapid plate-reader assay implementation
Deployment of ultra-rapid plate-reader instrumentation to perform fluorescent and luminescent assays across entire 96/384-well plates with electrical stimulation for high-throughput phenotyping.
Services
Tissue stretching and mechanical stimulation services
Application of controlled repetitive mechanical strain to multi-sample 3D tissue constructs and delivery of resulting mechanical-response data for research or screening projects.
Automated iPSC culture and differentiation screening (robotics)
Robotic cell- and tissue-culture services including standardized iPSC maintenance, passaging without centrifugation, differentiation-condition screening, gentle medium dispensing, and scale-up of cell production.
High-throughput optical and electrophysiology assay services
Plate-based fluorescence/luminescence assays with multi-channel electrical stimulation and rapid readout to profile electrophysiology, calcium transients, and related signals in cardiomyocytes and neurons.
Contract drug-screening and discovery using engineered cardiac tissues
Screening and profiling of compound libraries against engineered human cardiac tissue models to identify candidate therapeutics and support pipeline advancement.
Tissue stretching and mechanical stimulation services
Application of controlled repetitive mechanical strain to multi-sample 3D tissue constructs and delivery of resulting mechanical-response data for research or screening projects.
Automated iPSC culture and differentiation screening (robotics)
Robotic cell- and tissue-culture services including standardized iPSC maintenance, passaging without centrifugation, differentiation-condition screening, gentle medium dispensing, and scale-up of cell production.
High-throughput optical and electrophysiology assay services
Plate-based fluorescence/luminescence assays with multi-channel electrical stimulation and rapid readout to profile electrophysiology, calcium transients, and related signals in cardiomyocytes and neurons.
Contract drug-screening and discovery using engineered cardiac tissues
Screening and profiling of compound libraries against engineered human cardiac tissue models to identify candidate therapeutics and support pipeline advancement.
Expertise Areas
- Precision medicine for inherited heart failure
- iPSC-derived organ and tissue modeling
- High-throughput phenotypic screening
- Cardiac electrophysiology analysis
Key Technologies
- Human induced pluripotent stem cell (iPSC) models
- Gene-editing for disease modeling
- 3D engineered micro-tissues
- High-throughput optical phenotyping