Integral Molecular
Integral Molecular is a research-driven biotechnology company with over 20 years of experience specializing in membrane proteins, antibodies, and virology. They develop innovative technologies and therapeutic antibodies targeting challenging membrane protein targets such as GPCRs, ion channels, transporters, and viral envelopes. Their mission is to advance therapeutic discovery against difficult protein targets through proprietary platforms like Lipoparticles, MPS Antibody Discovery, and Epitope Mapping, supporting over 600 customers worldwide and collaborating with top biotech and pharmaceutical companies.
Industries
Nr. of Employees
small (1-50)
Integral Molecular
Philadelphia, Pennsylvania, United States, North America
Products
Virus-like particle reagents presenting membrane proteins
Noninfectious nanoscale particles that present conformationally intact membrane proteins at elevated surface concentration for immunization, display-based screening, ELISA, biosensor, and binding assays; available as custom batches, catalog items, or sample kits.
Proteome-scale cell-based specificity library (7,000+ proteins)
Unfixed cell expression library service representing thousands of human membrane and secreted proteins for off-target specificity testing, including expression QC, quantitative FACS readouts, hit validation, and regulatory-ready deliverables.
Replication-incompetent reporter virus particle kits
Validated reporter virus particle reagents bearing defined viral envelope proteins and optical reporters for infectivity and neutralization assays, provided with assay recommendations and permissive cell lines where applicable.
Virus-like particle reagents presenting membrane proteins
Noninfectious nanoscale particles that present conformationally intact membrane proteins at elevated surface concentration for immunization, display-based screening, ELISA, biosensor, and binding assays; available as custom batches, catalog items, or sample kits.
Proteome-scale cell-based specificity library (7,000+ proteins)
Unfixed cell expression library service representing thousands of human membrane and secreted proteins for off-target specificity testing, including expression QC, quantitative FACS readouts, hit validation, and regulatory-ready deliverables.
Replication-incompetent reporter virus particle kits
Validated reporter virus particle reagents bearing defined viral envelope proteins and optical reporters for infectivity and neutralization assays, provided with assay recommendations and permissive cell lines where applicable.
Services
Proteome-scale cell-based specificity screening (7,000+ proteins)
Unfixed cell-based screening representing thousands of human membrane proteins, with optional parallel screening of secreted proteins, quantitative flow-cytometry readouts, built-in hit validation, and IND-oriented reporting workflows.
Off-target risk analysis and validation services
Statistical analysis of proteome-screen results, cellular localization context, relative binding strength assessment, and follow-up dose-response validation experiments to support lead selection and safety assessment.
Shotgun mutagenesis epitope mapping service
Custom single-residue mutagenesis libraries expressed in human cells, high-throughput binding screens on live cells, control validations, and a final report delivering amino-acid-resolution epitope maps and publication-quality figures.
Comprehensive CDR-scanning and paratope mapping service
Library-based single-residue scanning across antibody CDRs with binding and expression readouts to define permissible substitutions and support antibody engineering and patent drafting; delivers full datasets and optional draft claim language.
High-throughput protein engineering and expressed variant delivery
Design and expression of arrays of single-amino-acid variant constructs in human cells, delivery of expressed supernatants, QC reports, and optional plasmid/glycerol stock provision for downstream assays.
Antigen reagent production using virus-like particles
Custom and prevalidated noninfectious particle reagents presenting specified membrane proteins at high density for immunization, screening, and biophysical assays; available with labeling and multiple QC metrics per batch.
Proteome-scale cell-based specificity screening (7,000+ proteins)
Unfixed cell-based screening representing thousands of human membrane proteins, with optional parallel screening of secreted proteins, quantitative flow-cytometry readouts, built-in hit validation, and IND-oriented reporting workflows.
Off-target risk analysis and validation services
Statistical analysis of proteome-screen results, cellular localization context, relative binding strength assessment, and follow-up dose-response validation experiments to support lead selection and safety assessment.
Shotgun mutagenesis epitope mapping service
Custom single-residue mutagenesis libraries expressed in human cells, high-throughput binding screens on live cells, control validations, and a final report delivering amino-acid-resolution epitope maps and publication-quality figures.
Comprehensive CDR-scanning and paratope mapping service
Library-based single-residue scanning across antibody CDRs with binding and expression readouts to define permissible substitutions and support antibody engineering and patent drafting; delivers full datasets and optional draft claim language.
High-throughput protein engineering and expressed variant delivery
Design and expression of arrays of single-amino-acid variant constructs in human cells, delivery of expressed supernatants, QC reports, and optional plasmid/glycerol stock provision for downstream assays.
Antigen reagent production using virus-like particles
Custom and prevalidated noninfectious particle reagents presenting specified membrane proteins at high density for immunization, screening, and biophysical assays; available with labeling and multiple QC metrics per batch.
Expertise Areas
- Proteome-scale specificity profiling for antibody and cell therapies
- High-resolution epitope mapping using single-residue mutagenesis
- Paratope mapping and CDR-scanning for antibody engineering and IP support
- Production and QC of membrane-protein-presenting virus-like particles
Key Technologies
- Shotgun mutagenesis (single-residue/alanine-scan) libraries
- Single–amino-acid CDR-scanning libraries
- High-throughput flow cytometry on live, unfixed cells
- Proteome-scale cell-based protein arrays