Integral BioSystems

An antimicrobial OcuSurf formulation incorporating moxifloxacin free base dissolved in the hydrophobic nanocores for enhanced membrane penetration.

A steroid-loaded OcuSurf formulation containing loteprednol etabonate (LE) for ocular administration.

A steroid-loaded OcuSurf formulation containing fluticasone propionate (FP) for ocular administration.

An antimicrobial OcuSurf formulation incorporating moxifloxacin hydrochloride dissolved in the hydrophilic phase.

OcuHeal is a highly efficient eye-drop delivery mechanism and lipid nanoparticle technology designed to maximize drug delivery to deeper ocular tissues and provide a cost-effective 505(b)(2) regulatory strategy.

A bioengineered, sustained-release drug delivery insert utilizing patented, nanostructured, biodegradable technology for applications in ophthalmic, intranasal, wound healing, women's health, urological, and otic delivery.

Integral BioSystems provides niche expertise in the design and development of PLGA microspheres for encapsulating proteins, peptides, oligonucleotides, and small molecules to achieve sustained release.

Comprehensive drug development services spanning formulation, preformulation studies, analytical methods, and technology transfer for pharmaceutical and biotech programs.

Formulation services for suspension-based formulations of hydrophobic compounds, specializing in ophthalmic disorders for both back-of-the-eye and front-of-the-eye applications.

CRO development services for parenteral and injectable drug delivery formulations, ensuring isotonicity, biocompatibility, and solubility.

Chemistry, Manufacturing, and Controls services including project planning, scale-up, technology transfer, and IND submissions.

Fee-for-service collaboration to develop injectable or eye-drop formulations using cyclodextrins for hydrophobic, water-insoluble products.

Integral BioSystems provides niche expertise in complex characterization techniques and analytical method development and transfer for small molecules, peptides, proteins, and nucleic acids.

Formulation development and analytical testing services for parenteral drug administration, focusing on isotonicity, biocompatibility, solubility, and stability.

Contract research organization services specializing in the design and development of transdermal and intradermal drug delivery systems, prototype fabrication, compatibility studies, and in-vitro diffusion experiments.

CRO services specializing in the design and implementation of drops, gel, and sustained release systems for otic and intra-tympanic drug delivery of small molecules and biologics.

Preclinical pharmaceutical formulation development services specializing in rectal drug delivery routes, including enemas, gels, and sustained release systems for small molecules and biologics.

Comprehensive drug characterization services including polymorph screening, pKa, log P, crystallinity, and analytical method development.

Contract research organization services focused on developing suspension-based and lipid-based dosage forms to enhance bioavailability of impermeable and insoluble drug substances for oral delivery.

State-of-the-art analytical instrumentation and testing services including deformulation studies, R&D stability testing, dissolution testing, and corneal permeability testing.

Analytical release testing services for sustained release dosage forms.

Contract research organization services specializing in the development of sublingual dose forms for rapid drug absorption into systemic circulation.