Centro Nacional de Biotecnología

Cloning of DNA fragments using the isothermal assembly technique (Gibson assembly).

Modular transcriptional unit assembly using Golden Standard technology.

Design and manufacture of custom parts using 3D printing and CAD.

Cloning of DNA fragments into plasmids using classical molecular biology techniques including restriction enzymes.

Mejora genética mediante técnicas sin manipulación (evolución dirigida, hibridación) y técnicas de ingeniería genética (OMGs) aplicada a la optimización de levaduras vínicas.

Multifors bioreactor setup featuring 0.5 L and 1 L working volumes.

Development of genome-scale metabolic models of microorganisms and microbial communities to analyze and identify metabolic bottlenecks and simulate gene insertions or deletions.

Advice on the improvement of microbial strains with industrial interest, providing a dossier with possible R&D actions.

B-Twin bioreactor units with 2 L and 5 L working volumes.

Provides advanced design and manufacturing tools for researchers in public and private entities to accelerate industrial biotechnology development for sustainable product production using a networked service structure following the DBTL (Design-Built-Test-Learn) cycle.

Pilot-scale bioreactor unit with a 30 L working volume.

Development of biotechnological processes for compounds of interest based on biotransformation reactions using isolated enzymes or resting cells.

Selección de nuevas levaduras a partir de una colección de más de 3.000 cepas aisladas de ambientes fermentativos y naturales para aplicaciones industriales, probióticos o prebióticos.

Incubation ovens for microbial culture maintenance.

Testing fermentation conditions for producing microorganisms in laboratory scale, alongside production, extraction, and purification.

Customized and suitable phage mixtures identification service for the elimination of one or more target bacteria in a specific environment using available characterization data and computational tools.

Multiparametric analyzer for metabolite and nutrient quantification.

Servicio de selección de cepas del género Saccharomyces para fermentaciones vínicas y cerveceras.

Engineered bacteria for cancer treatment featuring cell tumor-binding specificity and the ability to inject proteins into their cytoplasm with antitumor effects.

Tray lyophilizer unit available at the Bioprocess Pilot Plant facility.

High-pressure homogenizer for cell disruption and sample preparation.

Estudios en bodega experimental para optimización nutricional, reducción de consumo energético, control de grado alcohólico y síntesis de metabolitos usando modelización metabólica y gemelos digitales.

A specialized service to obtain and analyze microorganisms and their molecules, including fastidious microorganisms, under a broad variety of conditions for research and industrial development.

Continuous centrifuge for pilot-scale separation workflows.

Capacidad de secuenciación y análisis de genomas, transcriptómica funcional y análisis metagenómicos para estudios de terroir y diversidad microbiana.

Floor autoclave for sterilization processes.

Genome sequencing and analysis services including transcriptomics, metagenomics, and authentication systems development.

Access to a collection of over 3,000 yeasts isolated from fermentative and natural environments for industrial applications or probiotics.

Análisis de implantación de levaduras, control de alteraciones microbianas y desarrollo de aproximaciones a la carta para la identificación y caracterización de levaduras mediante técnicas moleculares como mtDNA, PCR cuantitativa y secuenciación de genomas.

Consulting and experimental design services for proteomics projects.

A tailor-made service offering the building of designer microarrays and running binding analyses, characterization of printed samples, and screening of binding properties.

Experimental cellar studies using metabolic modelling and digital twins to optimize fermentation conditions and resource consumption.