The David J. Gladstone Institutes
Gladstone Institutes is an independent biomedical research organization dedicated to tackling the biggest challenges in human health. By disrupting traditional scientific methods, Gladstone aims to make groundbreaking discoveries that can transform lives. The organization is renowned for its innovative approaches in research, focusing on conditions with significant medical, economic, and social impacts. Founded in 1979 from a donation by J. David Gladstone, the institute has expanded its research areas to include cardiovascular, neurological, and viral diseases, as well as data science and biotechnology.
Industries
Nr. of Employees
large (251-1000)
The David J. Gladstone Institutes
San Francisco, California, United States, North America
Products
Cardiovascular Disease Institute
Focuses on research related to heart diseases.
Data Science and Biotechnology Institute
Concentrates on integrating data science and biotechnology for biomedical research.
Genomic Immunology Institute
Dedicated to studying the genomic aspects of the immune system.
Neurological Disease Institute
Targets research on diseases affecting the brain and nervous system.
Virology Institute
Specializes in research on viruses and viral diseases.
Assay Development and Drug Discovery Core
Provides services for developing assays and discovering drugs.
Cardiovascular Disease Institute
Focuses on research related to heart diseases.
Data Science and Biotechnology Institute
Concentrates on integrating data science and biotechnology for biomedical research.
Genomic Immunology Institute
Dedicated to studying the genomic aspects of the immune system.
Neurological Disease Institute
Targets research on diseases affecting the brain and nervous system.
Virology Institute
Specializes in research on viruses and viral diseases.
Assay Development and Drug Discovery Core
Provides services for developing assays and discovering drugs.
Services
Flow cytometry core services and training
Instrument access, experimental design and panel setup support, antibody titration guidance, hands-on operation and software training, multi-parameter data acquisition, and downstream analysis assistance.
Genomics core: sequencing, library preparation, and automation support
Sequencing and single-cell assay services, low-input and strand-specific library-preparation support, consultation on reagent and automation platforms, and integration with computational pipelines.
Mass spectrometry and proteomics facility
Protein identification, quantification, and method development using mass spectrometry instrumentation and proteomics workflows.
Assay development and early drug-discovery collaboration
Collaborative projects to design, validate, and screen biological assays and to support progression of targets through early translational research stages.
Bioinformatics and data-science consultation
Custom computational pipelines, data-management services, machine-learning approaches, and multi-omics integration for analysis and interpretation of complex biological datasets.
Histology and microscopy services
Tissue processing, sectioning, staining, and light-microscopy imaging to support experiments requiring image-based analysis.
Flow cytometry core services and training
Instrument access, experimental design and panel setup support, antibody titration guidance, hands-on operation and software training, multi-parameter data acquisition, and downstream analysis assistance.
Genomics core: sequencing, library preparation, and automation support
Sequencing and single-cell assay services, low-input and strand-specific library-preparation support, consultation on reagent and automation platforms, and integration with computational pipelines.
Mass spectrometry and proteomics facility
Protein identification, quantification, and method development using mass spectrometry instrumentation and proteomics workflows.
Assay development and early drug-discovery collaboration
Collaborative projects to design, validate, and screen biological assays and to support progression of targets through early translational research stages.
Bioinformatics and data-science consultation
Custom computational pipelines, data-management services, machine-learning approaches, and multi-omics integration for analysis and interpretation of complex biological datasets.
Histology and microscopy services
Tissue processing, sectioning, staining, and light-microscopy imaging to support experiments requiring image-based analysis.
Expertise Areas
- Single-cell genomics and immune-repertoire analysis
- High-throughput sequencing assay development
- High-parameter cytometry and immunophenotyping
- Computational biology and machine-learning for multi-omics
Key Technologies
- Single-cell RNA sequencing and single-cell multi-omics
- scATAC-seq and single-cell data integration
- V(D)J immune-repertoire sequencing
- Next-generation sequencing and low-input library chemistries