Asimov, Inc.
Asimov is a company dedicated to the intelligent design of living systems, integrating cells, genes, and software to advance genetic design and biotherapeutics. They focus on enabling the design and manufacture of advanced therapies through their proprietary platforms and collaborations. They develop and provide tools, software, and services for cell line development, genetic construct design, and bioprocessing, including their flagship CHO Edge System and LV Edge System for lentiviral production. Their mission is to democratize state-of-the-art genetic design capabilities and accelerate biotherapeutic development.
Industries
Nr. of Employees
medium (51-250)
Asimov, Inc.
Products
GMP-banked host cell lines (CHO and HEK)
Characterized, traceable suspension-adapted clonal host cell vials (CHO and HEK) provided with supporting regulatory documentation and monoclonality evidence for use in cell line development and manufacturing.
Experimentally validated genetic parts library
A curated collection of characterized genetic parts for construct design and synthetic biology workflows, compatible with computational design tools.
Cloud-based genetic design and simulation platform
Software platform for codon optimization, vector layout design, biophysical simulation, predictive modeling of expression/titer, and workflow automation; integrated with parts libraries and host cell profiles, and augmented with physics-informed ML and multi-omics data integration.
AAV production toolkit (clonal host with optimized transient workflow)
A production toolkit that combines a clonal suspension-adapted HEK host, an optimized transient plasmid system, and model-guided process recipes to support high-titer AAV production and transfer to manufacturing.
Stable lentiviral packaging and producer cell banks
Clonal, suspension-adapted packaging and producer cell banks containing stably integrated inducible viral components or customer genes of interest, supplied with traceability and documentation for in-house or contract lentiviral production.
Physics-based AI design engine (in development)
A developing engine that combines mechanistic models, multi-omics data, and machine learning (including reinforcement learning) to improve predictive design of engineered cellular behaviors.
GMP-banked host cell lines (CHO and HEK)
Characterized, traceable suspension-adapted clonal host cell vials (CHO and HEK) provided with supporting regulatory documentation and monoclonality evidence for use in cell line development and manufacturing.
Experimentally validated genetic parts library
A curated collection of characterized genetic parts for construct design and synthetic biology workflows, compatible with computational design tools.
Cloud-based genetic design and simulation platform
Software platform for codon optimization, vector layout design, biophysical simulation, predictive modeling of expression/titer, and workflow automation; integrated with parts libraries and host cell profiles, and augmented with physics-informed ML and multi-omics data integration.
AAV production toolkit (clonal host with optimized transient workflow)
A production toolkit that combines a clonal suspension-adapted HEK host, an optimized transient plasmid system, and model-guided process recipes to support high-titer AAV production and transfer to manufacturing.
Stable lentiviral packaging and producer cell banks
Clonal, suspension-adapted packaging and producer cell banks containing stably integrated inducible viral components or customer genes of interest, supplied with traceability and documentation for in-house or contract lentiviral production.
Physics-based AI design engine (in development)
A developing engine that combines mechanistic models, multi-omics data, and machine learning (including reinforcement learning) to improve predictive design of engineered cellular behaviors.
Services
Contract cell line and upstream process development
Contract development of stable CHO and HEK producer cell lines and upstream process optimization, including pool generation, single-cell cloning with imaging-based monoclonality evidence, clone screening, fed-batch testing, stability studies, and delivery of research or GMP cell banks with supporting documentation.
Payload design and sequence optimization services
Design services for gene therapy payloads including sequence optimization, machine-learning-derived tissue-selective promoter design, and GOI silencing module design to improve expression, specificity, and manufacturability.
Cloud genetic design platform licensing and integration
Licensing and deployment of a cloud-based genetic design and simulation platform that integrates design tools, parts libraries, predictive models, experimental data, and workflow automation; configurable to customer standards and connectable to lab operations.
AAV and viral vector production system deployment and tech transfer
Production system deployment and transfer services that combine clonal suspension-adapted host cells, optimized plasmid systems, and model-guided processes; includes process documentation and transfer support to customer sites or manufacturing partners.
Analytical development and RCL detection testing
Analytical assay development and testing to characterize product quality attributes, perform stability studies, and run nucleic-acid-based replication-competent lentivirus detection assays aligned with regulatory expectations.
DNA construction, sequencing, QC, and reagent supply
Design, build, sequence verification, QC testing, and shipment of plasmids and DNA reagents to support in-house transfection and cell line workflows.
Contract cell line and upstream process development
Contract development of stable CHO and HEK producer cell lines and upstream process optimization, including pool generation, single-cell cloning with imaging-based monoclonality evidence, clone screening, fed-batch testing, stability studies, and delivery of research or GMP cell banks with supporting documentation.
Payload design and sequence optimization services
Design services for gene therapy payloads including sequence optimization, machine-learning-derived tissue-selective promoter design, and GOI silencing module design to improve expression, specificity, and manufacturability.
Cloud genetic design platform licensing and integration
Licensing and deployment of a cloud-based genetic design and simulation platform that integrates design tools, parts libraries, predictive models, experimental data, and workflow automation; configurable to customer standards and connectable to lab operations.
AAV and viral vector production system deployment and tech transfer
Production system deployment and transfer services that combine clonal suspension-adapted host cells, optimized plasmid systems, and model-guided processes; includes process documentation and transfer support to customer sites or manufacturing partners.
Analytical development and RCL detection testing
Analytical assay development and testing to characterize product quality attributes, perform stability studies, and run nucleic-acid-based replication-competent lentivirus detection assays aligned with regulatory expectations.
DNA construction, sequencing, QC, and reagent supply
Design, build, sequence verification, QC testing, and shipment of plasmids and DNA reagents to support in-house transfection and cell line workflows.
Expertise Areas
- CHO and HEK cell line development for biologics and viral vectors
- Stable packaging and producer cell line engineering for viral vector manufacturing
- AAV payload design and transient AAV production process development
- AI-driven genetic design and physics-informed modeling
Key Technologies
- Transposase-mediated multi-copy genomic integration
- Selection-marker attenuation strategies for clone enrichment
- Inducible expression systems for packaging cell lines
- Suspension culture adaptation in chemically-defined media