Biopico
Developer and provider of multi-organ microphysiological systems for human-relevant preclinical testing. Offers disposable glass-bottom multi-unit culture plates, recirculating gravity-driven fluidics, pre-seeded tissue plates and supporting software, analytical assays, and CRO services focused on biologics evaluation (e.g., T cell therapies, bispecifics, ADCs). Platforms are used for tumor–immune, BBB, liver–brain, islet–immune and other multi-tissue disease models and translational assays.
Industries
Nr. of Employees
small (1-50)
Patents
Fluidic array systems and testing for cells, organoids, and organ cultures
US-11807842-B2
View DetailsMicrofluidic devices and methods based on massively parallel picoreactors for cell and molecular diagnostics
US-9110026-B2
View Details
Fluidic array systems and testing for cells, organoids, and organ cultures
US-11807842-B2
View DetailsMicrofluidic devices and methods based on massively parallel picoreactors for cell and molecular diagnostics
US-9110026-B2
View DetailsProducts
OrganRX Plate
Injection-molded multi-unit disposable plate with glass bottom designed to host multiple organ compartments and support recirculating media flow and live imaging.
OrganRX System
Sterilizable recirculation system (single-plate and multi-plate configurations) that provides controlled shear flow across OrganRX plates with smart-device control and modular racks for scale-up.
OrganRX Tissue Plate
Assay-ready plates pre-seeded with cells in 3D gel matrices compatible with standard and confocal microscopy and designed for reproducible microvessel biology.
OrganRX Vascular Kit
Kit containing fibrinogen and thrombin gel components, endothelial and stromal cells, media and growth factors to generate perfusable vascularized tissue constructs.
OrganRX Software
Smart-device application (iOS) for monitoring and controlling recirculation parameters and experiments on the OrganRX System.
OrganRX™
OrganRX™ is a multi-organ microphysiological platform designed to support CRO services for biologics, including antigen-specific CD8+ T cells, bispecific T cell engagers, and antibody-drug conjugates. It uses a gravity-driven perfusion system to recirculate media and immune cells through multiple human organ models on a single plate.
OrganRX Plate
Injection-molded multi-unit disposable plate with glass bottom designed to host multiple organ compartments and support recirculating media flow and live imaging.
OrganRX System
Sterilizable recirculation system (single-plate and multi-plate configurations) that provides controlled shear flow across OrganRX plates with smart-device control and modular racks for scale-up.
OrganRX Tissue Plate
Assay-ready plates pre-seeded with cells in 3D gel matrices compatible with standard and confocal microscopy and designed for reproducible microvessel biology.
OrganRX Vascular Kit
Kit containing fibrinogen and thrombin gel components, endothelial and stromal cells, media and growth factors to generate perfusable vascularized tissue constructs.
OrganRX Software
Smart-device application (iOS) for monitoring and controlling recirculation parameters and experiments on the OrganRX System.
OrganRX™
OrganRX™ is a multi-organ microphysiological platform designed to support CRO services for biologics, including antigen-specific CD8+ T cells, bispecific T cell engagers, and antibody-drug conjugates. It uses a gravity-driven perfusion system to recirculate media and immune cells through multiple human organ models on a single plate.
Services
Preclinical evaluation of T cell therapies, bispecifics and ADCs using integrated multi-organ plates to measure efficacy, cytokine release, metabolism and off-target toxicity.
Design and creation of bespoke organ and disease models and tailored assays within the multi-organ plate format.
Throughput-adapted assays for dose–response testing, imaging-based tumor killing assays, PK/PD sampling and toxicity profiling across multiple organ compartments.
Preclinical evaluation of T cell therapies, bispecifics and ADCs using integrated multi-organ plates to measure efficacy, cytokine release, metabolism and off-target toxicity.
Design and creation of bespoke organ and disease models and tailored assays within the multi-organ plate format.
Throughput-adapted assays for dose–response testing, imaging-based tumor killing assays, PK/PD sampling and toxicity profiling across multiple organ compartments.
Expertise Areas
- Microphysiological systems (MPS) development
- Immuno-oncology modeling
- Drug metabolism and PK/PD
- Antibody–drug conjugate and bispecific evaluation
Key Technologies
- Multi-organ microphysiological systems (organ-on-plate)
- Gravity-driven unidirectional recirculation
- 3D tissue culture and spheroid/organoid models
- Vascularization with fibrin-based gels and endothelial networks
News & Updates
Presentation on human multiorgan microphysiological systems for modeling immunotherapies, tumor clearance, and normal tissue immune injury.
Presentation on senescence-based in vitro drug testing for Alzheimer's Disease using a liver–kidney–gut–brain multiorgan model.
Discussion of how LC-MS methods are used to profile drug metabolism and PK/PD in a recirculating multi-organ platform.
Overview of fluidic shear stress effects in multiorgan cultures and the role of controlled recirculation in modeling physiology.
Presentation on human multiorgan microphysiological systems for modeling immunotherapies, tumor clearance, and normal tissue immune injury.
Presentation on senescence-based in vitro drug testing for Alzheimer's Disease using a liver–kidney–gut–brain multiorgan model.
Discussion of how LC-MS methods are used to profile drug metabolism and PK/PD in a recirculating multi-organ platform.
Overview of fluidic shear stress effects in multiorgan cultures and the role of controlled recirculation in modeling physiology.