21st Century Medicine
21st Century Medicine is a research and development company specializing in advanced biopreservation technologies, including hypothermic preservation, cryopreservation, and vitrification. Their mission is to develop innovative solutions for the protection, preservation, transportation, and storage of living systems, with applications spanning from biopharmaceuticals to organ banking and reproductive technologies. They focus on creating custom solutions, developing preservation protocols, and advancing the science of cryobiology to improve patient care and biomedical research.
Industries
Nr. of Employees
small (1-50)
Patents
Methods for introduction and prolonged washout by organ perfusion of maximally vitrifiable cryoprotectant solutions at elevated temperatures
US-11849719-B2
View DetailsMethod of introduction and removal of high concentrations of cryoprotectants by vascular perfusion
US-11659835-B2
View Details
Methods for introduction and prolonged washout by organ perfusion of maximally vitrifiable cryoprotectant solutions at elevated temperatures
US-11849719-B2
View DetailsMethod of introduction and removal of high concentrations of cryoprotectants by vascular perfusion
US-11659835-B2
View DetailsProducts
Controlled vapor-phase ultra-low temperature storage unit (CIVS)
Programmable, computer-interfaced vapor-phase liquid nitrogen storage unit providing narrow temperature control, auto-monitoring, configurable racks and no direct liquid nitrogen contact.
Synthetic ice-blocking additive (non-colligative antinucleator)
A synthetic non-colligative ice-blocking additive designed to suppress early-stage ice growth during cooling and rewarming to improve vitrification stability.
Bacterial ice-nucleation inhibitor additive
Additive that specifically targets and inactivates bacterial ice-nucleating proteins to reduce environment-derived nucleation events in vitrification solutions.
Low-toxicity vitrification cryoprotectant for large tissues (VM3-style)
Concentrated cryoprotectant mixture formulated for vitrification of individual cells and large tissues with added antinucleators and ice growth suppressants; intended as a component for preparing vitrification solutions.
Concentrated vitrification cryoprotectant (VEG-style)
Concentrated, low-toxicity cryoprotectant mixture used to prepare modular vitrification solutions suitable across a range of systems and used in combination with antinucleators for added stability.
Controlled vapor-phase ultra-low temperature storage unit (CIVS)
Programmable, computer-interfaced vapor-phase liquid nitrogen storage unit providing narrow temperature control, auto-monitoring, configurable racks and no direct liquid nitrogen contact.
Synthetic ice-blocking additive (non-colligative antinucleator)
A synthetic non-colligative ice-blocking additive designed to suppress early-stage ice growth during cooling and rewarming to improve vitrification stability.
Bacterial ice-nucleation inhibitor additive
Additive that specifically targets and inactivates bacterial ice-nucleating proteins to reduce environment-derived nucleation events in vitrification solutions.
Low-toxicity vitrification cryoprotectant for large tissues (VM3-style)
Concentrated cryoprotectant mixture formulated for vitrification of individual cells and large tissues with added antinucleators and ice growth suppressants; intended as a component for preparing vitrification solutions.
Concentrated vitrification cryoprotectant (VEG-style)
Concentrated, low-toxicity cryoprotectant mixture used to prepare modular vitrification solutions suitable across a range of systems and used in combination with antinucleators for added stability.
Services
Project design, protocol development, experimental testing and investigator support for cryopreservation of cells, tissues and organs including vitrification method development.
Formulation and experimental validation of preservation and perfusion solutions, including experimental design for addition/removal protocols and cooling/rewarming profiles.
Quality Function Deployment (QFD)-based device specification, supplier assessment, FMEA, process capability assessment and prototype manufacture for cryobiology devices.
Custom-built programmable vapor-phase storage systems with configurable racks/canisters, computer interface, auto-monitoring and narrow temperature control for research specimen storage.
Preparation of written process descriptions for manufacture, control plans, FMEA, supplier assessments and support for FDA registration of solution formulations.
Preparation and packaging of research-use preservation solutions and support for international shipping and temperature-controlled storage.
Project design, protocol development, experimental testing and investigator support for cryopreservation of cells, tissues and organs including vitrification method development.
Formulation and experimental validation of preservation and perfusion solutions, including experimental design for addition/removal protocols and cooling/rewarming profiles.
Quality Function Deployment (QFD)-based device specification, supplier assessment, FMEA, process capability assessment and prototype manufacture for cryobiology devices.
Custom-built programmable vapor-phase storage systems with configurable racks/canisters, computer interface, auto-monitoring and narrow temperature control for research specimen storage.
Preparation of written process descriptions for manufacture, control plans, FMEA, supplier assessments and support for FDA registration of solution formulations.
Preparation and packaging of research-use preservation solutions and support for international shipping and temperature-controlled storage.
Expertise Areas
- Organ vitrification research
- Cryoprotectant chemistry and formulation
- Tissue banking and ultra-low temperature storage systems
- Contract cryobiology research services
Key Technologies
- Vitrification (ice-free cryopreservation)
- Concentrated low-toxicity cryoprotectant formulations
- Synthetic antinucleators / ice-blocking additives
- Ice growth-inhibiting polymers
News & Updates
Cryo2013 Conference Presentation
Greg Fahy presents on ice formation in the renal medulla at Cryo2013.
CRYO2013 Conference Presentation
Brian Wowk presents on metastable vitrification at CRYO2013.
Cryobiology: The Study of Life and Death at Low Temperatures
An overview of cryobiology principles, natural adaptations, and preservation techniques.
Cryopreservation of Organs and Tissues
Progress and challenges in organ vitrification and cryopreservation.
Advances in Cryoprotectants and Vitrification Solutions
Development of low-toxicity, ice-resistant solutions for biological preservation.
Future of Cryobiology
Emerging technologies and nanotechnology's role in cryopreservation.
Cryo2013 Conference Presentation
Greg Fahy presents on ice formation in the renal medulla at Cryo2013.
CRYO2013 Conference Presentation
Brian Wowk presents on metastable vitrification at CRYO2013.
Cryobiology: The Study of Life and Death at Low Temperatures
An overview of cryobiology principles, natural adaptations, and preservation techniques.
Cryopreservation of Organs and Tissues
Progress and challenges in organ vitrification and cryopreservation.
Advances in Cryoprotectants and Vitrification Solutions
Development of low-toxicity, ice-resistant solutions for biological preservation.
Future of Cryobiology
Emerging technologies and nanotechnology's role in cryopreservation.